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Yashar Zeighami

@yasharneuro.bsky.social
165 followers 238 following 2 posts

Neuroscientist-ish, Assistant Professor at the Douglas Research Centre, McGill University. Interested in neuroimaging, genomics, statistics, cats, books, ...

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Reposted by Yashar Zeighami
Julia M. Rohrer @dingdingpeng.the100.ci · 22/04/2026
Good news everyone 🥳 Our (w @vincentab.bsky.social) primer on models as prediction machines (with the marginaleffects package) is finally officially published!> journals.sagepub.com/doi/10.1177/...
journals.sagepub.com
Models as Prediction Machines: How to Convert Confusing Coefficients Into Clear Quantities - Julia M. Rohrer, Vincent Arel-Bundock, 2026
Psychological researchers usually make sense of regression models by interpreting coefficient estimates directly. This works well enough for simple linear model...
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Alain Dagher @alaindagher.bsky.social · 11/12/2025
Cortical expansion and genetic risk for PD. Led by Houman Azizi and Nooshin Abbasi. With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...
medrxiv.org
Brain size links neurodevelopment to neurodegeneration in Parkinson's disease
Genetic studies have advanced our understanding of Parkinson's disease (PD) pathogenesis, establishing a role for autophagy and lysosomal dysfunction. However, how genetic risk translates into neurona...
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Apurva Ratan Murty @apurvaratan.bsky.social · 04/12/2025
Need more fMRI data (beyond the amazing NSD)? Introducing MOSAIC! Incredible effort led expertly by Ben Lahner, with help from grad student Mayukh Deb. Work in collaboration with the amazing Aude Oliva! @neurosky.bsky.social. More below..
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allen institute @alleninstitute.org · 24/11/2025
Exciting new updates to the Allen Brain Cell Atlas! 🧵👇 #neuroskyence
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Jamie Hanson @jamielarsh.bsky.social · 23/09/2025
www.medrxiv.org/content/10.1...
medrxiv.org
Racial and Ethnic Disparities in Brain Age Algorithm Performance: Investigating Bias Across Six Popular Methods
Brain age algorithms, which estimate biological aging from neuroimaging data, are increasingly used as biomarkers for health and disease. However, most algorithms are trained on datasets with limited ...
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Bratislav Misic @misicbata.bsky.social · 10/09/2025
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
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allen institute @alleninstitute.org · 02/09/2025
Aging. It happens to all of us yet we don’t fully understand how it happens. Marni and Stephen Boppart from @ahsillinois.bsky.social are developing a new microscopy platform that can illuminate the role of extracellular vesicles in cellular aging. #FrontierScience alleninstitute.org/division/fro...
alleninstitute.org
Real-time label-free dynamic imaging of extracellular vesicles in live tissues
Researchers Marni and Stephen Boppart will use next-generation, multimodal, nonlinear optical microscopy techniques to obtain real-time, dynamic images of EVs in living tissues and use this advanced p...
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Mahsa Dadar @dadarmahsa.bsky.social · 02/09/2025
We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn
tinyurl.com
The Data Quartet Challenge.pdf
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Yani Bellini Saibene @yabellini.bsky.social · 10/08/2025
Still smiling after my keynote abt Community at #useR2025 💜 Huge thanks to the organizing team for the invite, and to everyone who joined, asked questions, and shared their thoughts — you made it truly special! Slides docs.google.com/presentation... Video: www.youtube.com/live/CTTvTQ-... #rstats
docs.google.com
WeRTogether-useR!2025Keynote
We R Together Yanina Bellini Saibene useR! 2025 Duke University How to learn, use and improve a programming language as a community
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Bratislav Misic @misicbata.bsky.social · 08/08/2025
Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour... How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️
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Aliza Brzezinski-Rittner @albrzez.bsky.social · 28/07/2025
Hey #AAIC25 ! Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠 Join me on poster 430! @ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social
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Eric Topol @erictopol.bsky.social · 05/06/2025
A healthy lifestyle in intervention clinical trials for weight loss, even without long term weight loss (only achieved in ~33%), led to improvement of key cardiometabolic factors academic.oup.com/eurjpc/advan...
academic.oup.com
Individual response to lifestyle interventions: a pooled analysis of three long-term weight loss trials
AbstractAims. We explored the manifestations of individual weight loss (WL) response to long-term lifestyle interventions on cardiometabolic risk.Methods a
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medRxivpreprint @medrxivpreprint.bsky.social · 05/06/2025
Vascular risk factors mediate the relationship between education and white matter hyperintensities www.medrxiv.org/content/10.1101/202…
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medRxivpreprint @medrxivpreprint.bsky.social · 04/06/2025
Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer's disease www.medrxiv.org/content/10.1101/202…
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medRxivpreprint @medrxivpreprint.bsky.social · 27/05/2025
Sex Differences in Vulnerability to Tau Pathology: Impact on Cognitive Decline www.medrxiv.org/content/10.1101/202…
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Healthy Brains, Healthy Lives @hbhlmcgill.bsky.social · 29/05/2025
Congrats to HBHL-funded researcher & 2022 HBHL New Faculty Recruit @dadarmahsa.bsky.social on being awarded the President’s Prize for Outstanding Emerging Researchers at the 2025 @mcgill.ca @healthsciences.mcgill.ca Convocation Ceremony! Well deserved. 👏 🔗 reporter.mcgill.ca/mcgills-pres...
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Hao Yin @haoyin.bsky.social · 22/05/2025
#SpatialTranscriptomics #BatchCorrelation SpaBatch Align multi-slice sequencing-based spatial data Visium ST Stereo-seq #VariationalGraphAutoEncoder Masked data augmentation vs STG3Net STAligner SEDR DeepST SpaGIC STitch3D bioRxiv 2025 www.biorxiv.org/content/10.1...
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Yipeng Li @moonliyp.bsky.social · 11/05/2025
(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.
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Imaging Neuroscience @imagingneurosci.bsky.social · 06/05/2025
New paper in Imaging Neuroscience by Gustavo Chau Loo Kung, Jennifer A. McNab, et al: Non-parametric prediction of brain MRI microstructure using transfer learning doi.org/10.1162/imag...
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Healthy Brains, Healthy Lives @hbhlmcgill.bsky.social · 06/05/2025
Sneak peek from first poster session at #HBHLSymposium2025 📸 With over 100 trainees presenting their innovative research on brain health, it's a great opportunity to explore new perspectives and pioneering work from the next generation of researchers! 🖼️🎓 @healthsciences.mcgill.ca
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Marc L Seal @parkvillegeek.bsky.social · 06/05/2025
A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images | Scientific Data www.nature.com/articles/s41...
nature.com
A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images - Scientific Data
Scientific Data - A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images
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Western BrainsCAN @westernubrainscan.bsky.social · 06/05/2025
@maximoprado.bsky.social and @mallarchak.bsky.social present their @westernubrainscan.bsky.social supported work on early biomarkers for development and monitoring of effective disease-modifying therapies at the #hbhlsymposium2025. @hbhlmcgill.bsky.social @westernu.bsky.social
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Healthy Brains, Healthy Lives @hbhlmcgill.bsky.social · 06/05/2025
Up next at #HBHLSymposium2025, @maximoprado.bsky.social & @mallarchak.bsky.social discussed their Initiative for Translational Neuroscience (ITN) collaboration & unpacked how early biomarkers help develop & monitor better treatments for neurodegenerative diseases. 🧪 @westernuresearch.bsky.social
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Nicola Rennie @nrennie.bsky.social · 06/05/2025
For #TidyTuesday this week, we're looking at data on terminations of NSF grants 📊 🎨 Using colour to highlight one category 📈 Transparency to highlight the important data ✍️ Annotations instead of a legend for transparency #RStats #ggplot2 #DataViz
Bar chart showing 651 NSF-funded research projects, with total terminated days in dark grey or red, completed days in light grey or red. Red highlights projects listed by Ted Cruz as "neo-Marxist class warfare propaganda".
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Julia M. Rohrer @dingdingpeng.the100.ci · 05/05/2025
This Thursday I will give a talk on (causal) mediation analysis -- happy to have finally worked out what I want to tell people. And happy to pilot a new mode of slide sharing: just putting them on my website (juliarohrer.com/resources/)
Title slide: Trust the process? (Causal) Mediation analysisDecision flowchart "So you want to conduct a mediation analysis"
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John Holbein @johnholbein1.bsky.social · 05/05/2025
You've heard of the many analysts projects, right? Scholars give the same dataset/question to a bunch of researchers & they still get different answers. Why is that? Data cleaning! This is consistent with Gelman's "garden of forking paths." Small coding decisions often drive results.
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Earl K. Miller @earlkmiller.bsky.social · 05/05/2025
Neuroblox: A biomimetic brain modeling platform to test interventions and generate new scientific insights. www.neuroblox.org #neuroscience
neuroblox.org
NEUROBLOX
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Axel Montagne @axelmontagne.bsky.social · 05/05/2025
www.thelancet.com/journals/ebi...
thelancet.com
Dissection of blood–brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders
CSF PDGFRβ, a candidate biomarker of BBB dysfunction, is increased in the early stages of neurodegenerative disorders, in association with neuroinflammation and axonal and synaptic damage.
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Eric Topol @erictopol.bsky.social · 02/05/2025
Epigenetic (methylation, biological) age is associated with increased risk of dementia and brain structural changes (including atrophy). From UK Biobank's 280,000 participants, ~4,800 cases of dementia over 14-year follow-up www.neurology.org/doi/10.1212/...
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jcohenadad.bsky.social @jcohenadad.bsky.social · 02/05/2025
Are you tired of getting signal dropout in your gradient echo EPI for spinal cord fMRI applications? Check out this new shimming study by Bréheret, D'Astous, Ma, Stockmann 🚀 👉 doi.org/10.1002/mrm....
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 02/05/2025
Awesome opportunity to work on women’s brain health with an absolute star — pls repost
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Hao Yin @haoyin.bsky.social · 28/04/2025
C-SIDE Cell type-specific inference of differential expression in #SpatialTranscriptomics 👉Work for both Sequencing- & Imaging-based ST 👉Need single-cell reference 👉Histological features as covariates 👉Pixel-based Segmentation-free DEA @naturemethods.bsky.social 2022 www.nature.com/articles/s41...
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Imaging Neuroscience @imagingneurosci.bsky.social · 20/04/2025
New paper in Imaging Neuroscience by Jack A. Reeves, Ferdinand Schweser, et al: IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease doi.org/10.1162/imag...
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Imaging Neuroscience @imagingneurosci.bsky.social · 15/04/2025
New paper in Imaging Neuroscience by Rebecca G. Clements, Molly G. Bright, et al: Quantitative mapping of cerebrovascular reactivity amplitude and delay with breath-hold BOLD fMRI when end-tidal CO2 quality is low doi.org/10.1162/imag...
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Annie G. Bryant @anniegbryant.bsky.social · 14/04/2025
@christopherjwhyte.bsky.social and I introduce a novel data-driven framework to evaluate >200 connectivity-based neural correlates of consciousness! Results are used to quantitatively compare predictions from neurodynamical models tailored to theoretic predictions. www.biorxiv.org/content/10.1...
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Amelie Metz @ameliemetz.bsky.social · 04/04/2025
Hey #ADPD2025 , I'm happy to present our work on characterizing brain atrophy and cerebrovascular pathology in Frontotemporal Dementia subtypes! Tomorrow, April 5, 9:40am, Hall F2, session: Mechanisms and Clinical Trials in FTD, ALS, and Neurodegeneration 02
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Marc L Seal @parkvillegeek.bsky.social · 04/04/2025
Multi-modal Monte Carlo MRI simulator of tissue microstructure | bioRxiv www.biorxiv.org/content/10.1...
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🌙 Lune Bellec @lune-bellec.bsky.social · 01/04/2025
🧠📊 Just out: a deeply sample structural brain and spine dataset from the cneuromod.ca team, now published in Imaging Neuroscience! led by Mathieu Boudreau and Julien Cohen-Adad. 📰 Paper here: lnkd.in/ewXA3dED 1/🧵
The CNeuroMod longitudinal brain and spine structural protocol
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Stephanie Noble @sneuroble.bsky.social · 30/03/2025
That’s right, go Imaging Neuroscience! @imagingneurosci.bsky.social @anastasiayendiki.bsky.social
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Eric Topol @erictopol.bsky.social · 30/03/2025
New @nejm.org #ACC25 The global impact of 5 cardiovascular risk factors (BP, cholesterol, obesity, diabetes, smoking) on life expectancy in men and women www.nejm.org/doi/full/10.1056/NEJMoa2415879
nejm.org
Global Effect of Cardiovascular Risk Factors on Lifetime Estimates | NEJM
Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular dise...
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Konrad Kording @kordinglab.bsky.social · 24/03/2025
Finally a new textbook for theoretical neuroscience. Xiao-Jing Wang wrote a nice book with very broad coverage of the field. Highly recommend. www.amazon.com/Theoretical-...
amazon.com
Theoretical Neuroscience: Understanding Cognition
Theoretical Neuroscience: Understanding Cognition: 9781032604824: Medicine & Health Science Books @ Amazon.com
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Joana B Pereira @joana-b-pereira.bsky.social · 24/03/2025
🧠 I'm excited to share our latest publication in Nature Communications: www.nature.com/articles/s41... In this study, we explore the computational memory capacity of the brain & how it declines with aging. A big thanks to Mite Mijalkov, all other lab members for their help and amazing collaborators!
nature.com
Computational memory capacity predicts aging and cognitive decline - Nature Communications
The capacity of brain networks to retain information during aging is crucial but not yet known. This study shows that the brain’s memory capacity, modelled with reservoir computing, offers new insight...
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Brain Communications @braincomms.bsky.social · 22/03/2025
Metz et al. report that a study combining MRI brain atrophy and clinical data using machine learning achieved 89% accuracy in classifying frontotemporal dementia subtypes. Please read at:https://buff.ly/uGmX2fg @DadarMahsa @YasharZeighami @sylv_villeneuve @sducharme66
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Ben Fulcher @bendfulcher.bsky.social · 21/03/2025
Latest work on tailoring overlapping community detection algorithms to a given network dataset, and the unique insights it can provide about human brain #complexnetwork architecture. Check the thread and preprint out below :)
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techaltar.bsky.social @techaltar.bsky.social · 17/03/2025
Hah, the French govt, with some help from Germany, is building an open source Notion clone. Fun! github.com/suitenumeriq...
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Francis Sedgemore @hesgen.com · 17/03/2025
Canada joins Horizon Europe programme
luxembourg.representation.ec.europa.eu
Canada joins Horizon Europe programme
Canada is joining the growing group of non-EU countries who have associated to the EU's research and innovation programme, Horizon Europe, and will work jointly on large-scale projects tackling our bi...
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Tiago Peixoto @tiago.skewed.de · 12/03/2025
🚨 New paper on ArXiv: “Uncertainty quantification and posterior sampling for network reconstruction” TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics. Short thread: 1/N
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Bratislav Misic @misicbata.bsky.social · 11/03/2025
Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025... How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️
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Michael Okun @michaelokun.bsky.social · 05/03/2025
Did you know there are 400 miles of blood vessels in the human brain? Did you know there is also a complex blood–brain barrier which protects us, but also can block drug and innovative gene therapies. Rust and colleagues discuss both sides of the 'wall' that protects our brain in the journal Brain.
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