Dysfunction of glial and vascular cells is increasingly recognized as a central feature of neurodegenerative diseases. Growing evidence points to disruptions in glial-vascular interactions, which are ...

PhD Project - Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London, listed on FindAPhD.com

PhD at the University of Edinburgh on small vessel disease using imaging, AI & metabolic profiling to study brain cell dysfunction and test therapeutic targets.

Apply for a PhD: Vascular Contributions to Dementia and Neurodegeneration at University College London

YouTube video by UK Dementia Research Institute - UK DRI

PhD Project - EASTBIO Transcriptomic signatures underlying neuroimaging white matter inflammation and abnormalities in the ageing brain at University of Edinburgh, listed on FindAPhD.com

PhD Project - VIDA DTC - Decoding the Vascular Origins of Alzheimer’s Disease Through Advanced Imaging and Proteomic at University of Edinburgh, listed on FindAPhD.com

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

PhD Project - EASTBIO Transcriptomic signatures underlying neuroimaging white matter inflammation and abnormalities in the ageing brain at University of Edinburgh, listed on FindAPhD.com

Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and broad neurovascular involvement in SVD. They highlight novel regulatory pathways and potential therapeutic targets, advancing understanding of these comorbid conditions for future treatment strategies.

Here, Audrey Chagnot and Axel Montagne discuss the structural and functional features of the blood–brain barrier and the association of its disruption with various pathologies.

In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coord…

We are looking for an enthusiastic postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.

Although strong evidence exists for blood–brain barrier (BBB) disruption in Alzheimer’s disease (AD), substantial uncertainty remains regarding its ro…

Cerebral small vessel disease (cSVD) refers to all pathologies of the brain’s arterioles, capillaries, and venules. cSVD is highly prevalent with ageing and is diagnosed by its characteristic neuro-im...

Alzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular co…

Brain pericyte injury may contribute to the onset and progression of POD by influencing the blood–brain barrier's capacity to clear Aβ protein. The combination of CSF sPDGFRβ with CSF AD biomarkers e...

INTRODUCTION This study explored the relationship between blood biomarkers of cerebrovascular function and small vessel disease (SVD) neuroimaging markers and cognitive outcomes in highly-phenotyped...

CSF PDGFRβ, a candidate biomarker of BBB dysfunction, is increased in the early stages of neurodegenerative disorders, in association with neuroinflammation and axonal and synaptic damage.

In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Cerebral small vessel disease (SVD) is recognized as a major vascular contributor to cognitive decline, ultimately leading to dementia and stroke. While the pathogenesis of SVD remains unclear, emer...

INTRODUCTION This study explored the relationship between blood biomarkers of cerebrovascular function and small vessel disease (SVD) neuroimaging markers and cognitive outcomes in highly-phenotyped...