iiinova — where your digital self keeps evolving

Paul Thompson @ptenigma.bsky.social · 9h

For those of you @MICCAI 2026 in Strasbourg, no sleeping in tomorrow or going to see the Cathedral... 🔥 be in Room Curie B at 8am sharp for Evelyn Deutscher and Emily Dennis's BrainWorks 2026 Workshop* 🧨 *yes I will give a talk 1030am in Room Curie B youtube.com/watch?v=hknx...

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Paul Thompson @ptenigma.bsky.social · 28/09/2026

Heading to #MICCAI2026 (hopefully get there before it’s over !)

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Paul Thompson @ptenigma.bsky.social · 28/09/2026

Air France has good WiFi! Very helpful for finishing a talk. 🔥MICCAI is in Strasbourg, I wish we could take the conference students to meet the Gamma calculus/stochastic PDE people across town! 🔥very famous city for mathematics, w Bakry/Emery discovering mind blowing results there for over 50 years

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Paul Thompson @ptenigma.bsky.social · 24/09/2026

🔥COME TO Pepperdine this Fri + Sat for the Human-Centered AI Conference* *yes I will give a talk ! (summarised below) 🔥 Programme (featuring Judea Pearl, Katie Bouman, ++): seaver.pepperdine.edu/events/human...

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Paul Thompson @ptenigma.bsky.social · 21/09/2026

🔥 OK I just posted a NEW VIDEO: 🔥 Can AI Diagnose Every Brain Disease? Data Scaling Laws & the ENIGMA Consortium | MICCAI 2026 youtube.com/watch?v=hknx... 🔥 Can AI diagnose every brain disease from an MRI with over 90% accuracy? And if not, how much more data would it take?

youtube.com

Can AI Diagnose Every Brain Disease? Data Scaling Laws & the ENIGMA Consortium | MICCAI 2026

YouTube video by Paul M. Thompson

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Paul Thompson @ptenigma.bsky.social · 19/09/2026

This paper looks like it would have been fairly annoying to write on a typewriter* *for those born this century, it was a machine where you didn't need a printer, as you were the printer :)

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Paul Thompson @ptenigma.bsky.social · 19/09/2026

Wonderful to catch up with Professor Liang Zhan today who gave an incredible talk on about 10 extremely challenging problems in 30 minutes (!). In one ingenious paper, PACE [1], developed with Alex Leow, detects hierarchical communities in functional MRI by repeatedly splitting the brain network..->

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Paul Thompson @ptenigma.bsky.social · 15/09/2026

I will teach scaling laws/crossover theory @MICCAI2026 as machine learning/CS papers often rank AI methods but the rank order depends on the training N, encoder dimension p + spectral slope of the data covariance. You can find the crossover with Gamma calculus-invented in Strasbourg where MICCAI is!

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Paul Thompson @ptenigma.bsky.social · 14/09/2026

🔥Next talks (see you there!) 1⃣Sep 26 - Pepperdine University (New Directions in Generative and Diagnostic AI) 2⃣Sep 28/29 - NINDS/NIA Workshop on Parkinson's and Alzheimer's Disease 3⃣Oct 1 - MICCAI (Strasbourg) "Worldwide Collaboration, AI & Data Scaling Laws in the Quest to Map Human Brain Diseases"

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Paul Thompson @ptenigma.bsky.social · 14/09/2026

🔥Making animations for a spectral theory lecture. Which is best? Claude (Opus 5 High)=on top, ChatGPT (Astra Medium)=on the bottom. 🔥 I slowed them down so there is time to make sense of the formulas

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Paul Thompson @ptenigma.bsky.social · 13/09/2026

OK folks I just made a new VIDEO: "Parkinson’s & Alzheimer’s: What Large-Scale Brain Studies Reveal" www.youtube.com/watch?v=WDqw... I hope you like it!

youtube.com

Parkinson’s and Alzheimer’s: What Large-Scale Brain Studies Reveal

YouTube video by Paul M. Thompson

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Paul Thompson @ptenigma.bsky.social · 11/09/2026

So I drove to a mysterious location in Venice this afternoon and there is a private home* set up like a TV studio to record the Dr Mark Hyman show. He is a very kind person, so much energy, creative and a bit of a maverick and ahead of this time in his views, a much more practical person than me.

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Paul Thompson @ptenigma.bsky.social · 10/09/2026

Tomorrow I'll go to a studio in Venice* to be interviewed on the Dr Mark Hyman Show (a bit nerve-racking) 🔥Here's[1] his interview with Dr Iain Campbell, a leading neuroscientist who recovered from bipolar disorder+studies pioneering treatments [1] www.youtube.com/watch?v=YCcZ... *in LA not Italy

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Paul Thompson @ptenigma.bsky.social · 08/09/2026

Apocalyptic double rainbow in the LA sky, rainbow #2 is 9 degrees outside the first one but colors are in reverse order (red at the smaller viewing angle (~50°) and violet at the larger one (~53°) due to 2 reflections inside each raindrop

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Paul Thompson @ptenigma.bsky.social · 06/09/2026

Raining in LA for the first time in 159 days !

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Paul Thompson @ptenigma.bsky.social · 03/09/2026

Triumph of the day was moving this sleeping cat that had not gone to sleep in a very sensible place

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Paul Thompson @ptenigma.bsky.social · 01/09/2026

I'll be giving a Keynote Talk @ #MICCAI2026 in Strasbourg. 🔥But did you know French mathematicians Meyer, Bakry+Émery invented the Gamma-calculus in Strasbourg ~50 y ago ? 🔥Come see how the Strasbourg group's Gamma-calculus governs diagnostic classifier accuracy as training data gradually comes in!

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Paul Thompson @ptenigma.bsky.social · 30/08/2026

YOUR LIFETIME % risk for various brain conditions* 🔥 diseases with larger effects on the brain tend to be less common, which I explain here youtube.com/watch?v=3iWp... 🔥young-onset often have higher lifetime risk 🔥yes research funding is not proportionate *slide I made for an upcoming ENIGMA talk

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Paul Thompson @ptenigma.bsky.social · 29/08/2026

The last author (Carlos Cruchaga) is a very modest person, I had lunch with him on Thursday and we talked about omics/imaging for neuropath classification + he didn't even mention his amazing new cool finding !!

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Paul Thompson @ptenigma.bsky.social · 29/08/2026

I'm going to have to update my neurogenetics class in the Fall with this cool new result (July Nature Medicine): 🔥a 34-circRNA "circular RNA" blood signature detected biomarker-confirmed Alzheimer’s disease with AUC=0.945 ...

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Paul Thompson @ptenigma.bsky.social · 29/08/2026

Almost home (Los Angeles, 8pm)

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Paul Thompson @ptenigma.bsky.social · 26/08/2026

🔥 TOMORROW at NIH I will give a talk on dementia subtyping using AI, specifically knowledge distillation. 🔥 Recently neuroimaging and proteomics AI-based methods for differential diagnosis of Alzheimer’s disease, LATE/TDP-43, LBD and vascular disease have different strengths with CSF/PET ..

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Paul Thompson @ptenigma.bsky.social · 23/08/2026

🧠 NEW LECTURE NOTES HERE: 🔥 zenodo.org/records/2206... 🔥 Thompson, P.M. (2026). “Beyond the Spectral Horizon: Predicting and Accelerating Scientific Discoverability” [Lecture Notes].* *will be a video lecture series soon... !

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Reposted by Paul Thompson

Sofie Valk @sofievalk.bsky.social · 20/08/2026

Super proud of the work led by @meikehettwer.bsky.social activating a tour du force of six enigma working groups (depression, bipolar disorder, schizophrenia, anxiety, obsessive compulsive disorder, and autism) plus enigma gradients to a 20.000+ lifespan sample from 172 sites and 6 continents

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Paul Thompson @ptenigma.bsky.social · 13/08/2026

Not the eclipse (but a nice sunset)

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Paul Thompson @ptenigma.bsky.social · 12/08/2026

If you are here check out today’s total / partial SOLAR eclipse (and post photos!)

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Reposted by Paul Thompson

Katherine Lawrence @kelawrence.bsky.social · 10/08/2026

We also found that autism was associated with widespread lower white matter volumes, on average. Widespread white matter differences were observed across major projection, commissural, and association pathways, as well as cerebellar and brainstem white matter.

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Paul Thompson @ptenigma.bsky.social · 11/07/2026

Does anyone have a telescope ?

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Paul Thompson @ptenigma.bsky.social · 11/07/2026

Made it to London and it's very hot ! 🔥

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Paul Thompson @ptenigma.bsky.social · 11/07/2026

Amazing win by Harri and Henry in the Wimbledon men’s final. Apparently there is another England Scandinavia game in 2 hours ? :) 🇳🇴🏴󠁧󠁢󠁥󠁮󠁧󠁿

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Paul Thompson @ptenigma.bsky.social · 06/07/2026

No way 🏴󠁧󠁢󠁥󠁮󠁧󠁿England 2 🇲🇽Mexico 1 @ half time. ... #FIFAWorldCup #FIFA #WorldCup

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Paul Thompson @ptenigma.bsky.social · 05/07/2026

Probably a bit closer than you are supposed to sit

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Paul Thompson @ptenigma.bsky.social · 30/06/2026

2 weeks ago at OHBM, great opportunity to speak French, parce que c'est l'occasion. Thanked Hervé for finding us a great ENIGMA venue. Taxi driver helped pronounce it better. French is more compact than English, a sign read: "Tout abus sera puni". can't be said in another language in 16 letters? :)

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Paul Thompson @ptenigma.bsky.social · 30/06/2026

The OHBM conference (Bordeaux) was a great opportunity to speak French, parce que c'est l'occasion. I thanked Hervé for finding us a great venue. Taxi driver helped me to pronouce it better. +Look at its very high compression: "Tout abus sera puni". Cannot be said in another language in 16 letters?

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Paul Thompson @ptenigma.bsky.social · 28/06/2026

🔥Optimizing the future rate of discovery using the zeta law [1] + future-optimized encoders* *maybe it would be easier to just bet on the World Cup [1] arxiv.org/pdf/2604.17581 sequel coming next week

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Paul Thompson @ptenigma.bsky.social · 19/06/2026

Almost there * *the rental car man at Manchester airport said “are you going to drive far”

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Paul Thompson @ptenigma.bsky.social · 17/06/2026

You can tell England has scored without watching the TV as there is basically yelling that is correlated with something good happening

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Paul Thompson @ptenigma.bsky.social · 17/06/2026

People here basically start eating their tea at 1030pm as it’s so hot

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Paul Thompson @ptenigma.bsky.social · 17/06/2026

🔥 100°F+ ENIGMA PARTY @OHBM2026, Bordeaux. 🔥What a night! Thanks to everyone* who joined us+1000000 thanks to Sophia Thomopoulos for organising 🔥 🔥 *Pictured, Row 1: PT, Katharina Wittfeld, Sven Cichon, Alexander Teumer, Thomas Müliesen; Clara Moreau, Johanna Bayer, Lune Bellec, Andrei Irimia, ..👇

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Paul Thompson @ptenigma.bsky.social · 09/06/2026

As the World Cup is starting, you are probably wondering if it is possible to make a Hamiltonian path that traverses all nodes+ edges of a soccer ball only once but returns to its initial position.* If you see anyone playing soccer, you should stop the game and ask them this. *Bonus puzzle below...

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Paul Thompson @ptenigma.bsky.social · 04/06/2026

🔥 NEW VIDEO discussion of current research in Alzheimer's, Parkinson's, schizophrenia, bipolar disorder, depression, autism, ADHD; tune in here: 🔥 Part 1 www.youtube.com/watch?v=N7YB... 🔥 Part 2 www.youtube.com/watch?v=RHmr...

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Reposted by Paul Thompson

ENIGMA-Diabetes @enigmadiabetes.bsky.social · 29/05/2026

New multicohort study (N=1,965) finds maternal metabolic health may shape early brain development in sex-specific ways. rdcu.be/flutX @enigmabrains.bsky.social @ptenigma.bsky.social

rdcu.be

Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study

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