Michael Okun @michaelokun.bsky.social · 3hMini-brains in a dish: why are Parkinson’s and Alzheimer’s researchers are so excited? New review in Brain shows how rapidly these models are becoming more sophisticated and why they could change the way we study diseases like Parkinson’s and Alzheimer’s. 020
Michael Okun @michaelokun.bsky.social · 30/09/2026Bravo on the recent reauthorization of ACT for ALS. This bill was critically important because federal programs were set to expire, threatening momentum in expanded access to investigational therapies and ALS research. Additionally, researchers have been using HEALEY to move promising drugs faster. 000
Michael Okun @michaelokun.bsky.social · 29/09/2026Although clinical trials suggest that some of the problems traditionally associated with dopamine agonists may occur less frequently with this more selective drug, as tavapadon moves into real-world use we need to remain vigilant for the full spectrum of dopamine agonist related effects. 011
Michael Okun @michaelokun.bsky.social · 28/09/2026I love sports and recognize everything they can give a child including fitness, teamwork, confidence and community; however I think we should be asking whether tackle football needs to begin so young? Consider there is plenty of time to learn how to tackle and only one developing brain to protect. 030
Reposted by Michael OkunScientific American @sciam.bsky.social · 26/09/2026Fermi Explorer—a plan to send a probe on an 80,000-year trip to Alpha Centauri—is meant to show the feasibility of interstellar voyages. The trouble is we’ve already been sending spacecraft to the stars for nearly 50 years. Is this new effort worthwhile?scientificamerican.comNASA has launched five interstellar missions. Should this private venture launch a sixth?Fermi Explorer, a proposed low-cost private mission to Alpha Centauri, seeks to address a question that’s already been answered 3296
Reposted by Michael OkunScientific American @sciam.bsky.social · 27/09/2026Mathematicians (amateur and professional) used AI to find all 25,000 cases of one “inverse Galois problem,” solving a decades-old conundrum.scientificamerican.comMathematicians use AI to find mysterious symmetries, solving decades-old problemIn parallel, a race by amateurs and mathematicians has found all 25,000 cases of one “inverse Galois problem” 0178
Michael Okun @michaelokun.bsky.social · 27/09/2026David Charles said something that blew me away. This is year 20 for our annual focus on common movement disorders course at Vanderbilt University. Almost every academic movement disorder program in the US features one or more of our graduates. That defines impact. 000
Michael Okun @michaelokun.bsky.social · 26/09/2026Negative trials matter, particularly in ALS. We need failures to get successes. Thomas Edison is credited with reframing his repeated attempts to build the light bulb as, “I have not failed. I've just found 10,000 ways that won't work.” That is how we should view well-designed negative trials. 041
Reposted by Michael OkunThe Parkinson's Foundation @parkinsondotorg.bsky.social · 24/09/2026Learn how to get involved with Parkinson's disease research! 🔬 Parkinson.org/library/fact-sheets/researchparkinson.orgGetting Involved in ResearchLearn more about the Parkinson's disease research process and how to get involved. 011
Reposted by Michael OkunScientific American @sciam.bsky.social · 24/09/2026Apple "detectives" wanted to identify a gnarly old tree growing on a remote plot of land in Maine. What they discovered was the key to a centuries-old apple mystery.scientificamerican.comHow apple detectives solved the mystery of an ancient tree—and rewrote the history of fruitAnd how they might have helped save the future of American apples 401121389
Reposted by Michael OkunScientific American @sciam.bsky.social · 25/09/2026Can a six-dimensional sphere be described using imaginary numbers? For decades, experts puzzled over this question. Now an AI has apparently answered it.scientificamerican.comAI solves 79-year-old math mystery of six-dimensional spheresCan a six-dimensional sphere be described using imaginary numbers? For decades, experts puzzled over this question. Now an AI has apparently answered it 4257
Michael Okun @michaelokun.bsky.social · 25/09/2026We need cleaner air and better research, but we should also be thinking about practical ways to reduce our individual exposures while the science continues to evolve. Do you have a HEPA air filter in your home, and do you wear a mask outside on polluted days? 010
Michael Okun @michaelokun.bsky.social · 23/09/2026This quick flip-through gives you a look inside a book designed to move beyond confusing dietary advice and toward practical choices you can actually use. youtube.com/shorts/Sk7uU... 020
Michael Okun @michaelokun.bsky.social · 23/09/2026My take on the negative ceperognastat trial for AD. I would not interpret this as evidence that tau is the wrong target; tau burden remains closely linked to neurodegeneration and clinical decline, and several next-generation tau approaches remain under study. 000
Michael Okun @michaelokun.bsky.social · 22/09/2026What resonates most with me about Carey Gillam’s deeply reported piece is not simply the continuing concern about paraquat and Parkinson’s disease, but the question of whether our regulatory system has been working with the full deck of cards. www.thenewlede.org/2026/09/syng... 010
Michael Okun @michaelokun.bsky.social · 22/09/2026Could the human brain begin as two different developmental programs? And what could this mean for Parkinson’s, Alzheimer’s and ALS? Neural ectoderm progenitors are very early cells that ultimately give rise to the brain. nature.com/articles/s41... 020
Michael Okun @michaelokun.bsky.social · 21/09/2026Can we trust AI chatbots for PD information? Generative AI chatbots use artificial intelligence to create conversational answers to questions, but in health care a convincing answer is not necessarily a correct or safe answer. Meet AI chatbot called jAImes. www.thelancet.com/journals/lan... 030
Michael Okun @michaelokun.bsky.social · 20/09/2026Team Fox Detroit gala celebrated 10 years last night and an honor to unbox and give away the first 300 Parkinson's Plate books. Team Fox is creating impact and has raised 1.6 million dollars for PD research! Donna and Mike are knocking Parkinson's out of the park. us.amazon.com/Parkinsons-P... 021
Reposted by Michael OkunScientific American @sciam.bsky.social · 17/09/2026Check out the first new species of wild cat discovered in more than a century. The even better news: it’s adorable.scientificamerican.comSee the first new species of cat discovered in more than a century—it’s adorableThe cat is smaller than a house cat but has the spots of a leopard 27124
Reposted by Michael OkunScientific American @sciam.bsky.social · 18/09/2026What is the next number in this sequence: 1, 2, 4, 8, 16 ... ? The answer may surprise you and it has to do with Moser's circle problem.scientificamerican.comHow pizza can solve this unusual math puzzleMoser’s circle problem can be used to divide a pizza into one, two, four, eight, 16 or 31 slices. It’s a perfect example of how the numbers in a sequence aren’t as clear-cut as they may first appear 3167
Reposted by Michael OkunLead-DBS @lead-dbs.org · 19/09/2026New publication using Lead-DBS: In this article by Hanafi et al., the authors tested gait-adaptation kinematics, EEG, and FDG‑PET in Parkinson's patients during virtual obstacle avoidance with active versus paused STN‑DBS and... Check out the paper here 👇👇 doi.org/10.1016/j.brs.2026.103207 025
Michael Okun @michaelokun.bsky.social · 18/09/2026What resonated with me from the final session of DBS Think Tank XIV on digital health-guided neuromodulation was how rapidly digital tools are beginning to connect the entire therapeutic journey, from predicting and planning to programming and long-term monitoring. 021
Michael Okun @michaelokun.bsky.social · 18/09/2026What resonated with me from this morning’s DBS Think Tank session on advanced imaging in neuromodulation was how imaging is rapidly evolving from a picture of anatomy into a roadmap of the circuits we want to understand and modulate. 063
Michael Okun @michaelokun.bsky.social · 18/09/2026One of my favorite moments from this morning’s DBS Think Tank came from Nico Dosenbach, who reminded us of the famous story of Charles Steinmetz and Henry Ford. The chalk marked “X” on exactly the right spot; and told the engineers where to make the repair. Check out the invoice. 042
Michael Okun @michaelokun.bsky.social · 17/09/2026“Deep brain stimulation” can sound frightening; “brain pacemaker” is simpler, more familiar and may better communicate what we are actually trying to do: use an implanted device to help restore function and improve lives. 031
Michael Okun @michaelokun.bsky.social · 17/09/2026What resonated with me from today’s DBS Think Tank session on electrophysiology-guided neuromodulation was how rapidly we are moving from simply recording brain signals to understanding which physiology actually matters and then using it to guide therapy. 032
Michael Okun @michaelokun.bsky.social · 17/09/2026Industry continues to blaze new paths, but the magic happens when engineers and innovators work shoulder-to-shoulder with academicians and clinicians to ask the difficult questions, perform the rigorous studies and generate the evidence necessary to push the horizon. Great DBS Think Tank session. 120
Michael Okun @michaelokun.bsky.social · 17/09/2026What resonated with me most from this morning’s DBS Think Tank session on sEEG-guided neuromodulation was the sense that we are moving beyond simply asking where to stimulate and toward understanding the circuits, signals and physiology that can tell us how to stimulate better. 021
Michael Okun @michaelokun.bsky.social · 16/09/2026What resonated with me from today’s DBS Think Tank session on neuromodulation of mood and cognition was how quickly we are moving from simply observing these remarkably complex human circuits to recording, understanding and potentially modulating them in the real world. 083
Michael Okun @michaelokun.bsky.social · 16/09/2026What resonated with me from our first session of the DBS Think Tank was the remarkable promise, and also the complexity, of neuromodulating the cerebellum. We are learning that the cerebellum is far more than a motor structure; its circuits reach into movement, cognition, emotion and behavior. 020
Michael Okun @michaelokun.bsky.social · 16/09/2026Today we begin the next conversation. DBS Think Tank XIV is officially underway. Open to everyone and especially persons w/ disease. View the agenda & register: fixel.ufhealth.org/think-tanks/... 051
Reposted by Michael OkunScientific American @sciam.bsky.social · 15/09/2026The Denisovans are considered one of modern humans’ closest ancient ancestors, yet we know very little about how they looked or lived. A new analysis gives tantalizing clues, suggesting they may have looked more like us than we thought.scientificamerican.comScientists unlock new clues to what a mysterious ancient human ancestor looked likeAn analysis of ancient bones found in a Chinese cave offer glimpses of how Denisovans lived more than 130,000 years ago 24411
Michael Okun @michaelokun.bsky.social · 15/09/2026Could we be missing one of the most treatable causes of walking and thinking problems in older adults. New review in JAMA why idiopathic NPH deserves our attention, particularly because it can mimic PD and AD and, importantly, symptoms can improve following treatment. jamanetwork.com/journals/jam... 030
Reposted by Michael OkunThe Parkinson's Foundation @parkinsondotorg.bsky.social · 14/09/2026This week's Fitness Friday is LIVE! 💪 This workout will include the five fundamental human movements (push, pull, hinge, squat & loaded carry) to support activities of daily living. Register for free: Parkinson.org/events/2026/Sep18FF parkinson.orgLive Fitness Friday - Move to ImproveJoin us for a live fitness class, offered once a month. 021
Reposted by Michael OkunScientific American @sciam.bsky.social · 14/09/2026Quiet rest helps with memory consolidation, the process through which newly formed memories become more stable.scientificamerican.comWhy doing nothing is good for your brainThe case for not filling up every minute of your day 06922
Michael Okun @michaelokun.bsky.social · 13/09/2026What resonates with me about this important 15-year follow-up is the reminder that when parkinsonism emerges years after GPi DBS for dystonia, we should be cautious about automatically blaming the stimulation. movementdisorders.onlinelibrary.wiley.com/doi/10.1002/... 010
Michael Okun @michaelokun.bsky.social · 12/09/2026What resonates with me most about this paper is something we see far too often in Parkinson’s care: as the disease progresses and people need us the most, they can become the very people we lose from care. www.neurology.org/doi/pdf/10.1... 011
Reposted by Michael OkunScientific American @sciam.bsky.social · 08/09/2026Google’s DeepMind isn’t done transforming genetics, it seems: today the group released a new atlas that predicts every possible effect caused by nine billion possible single changes in the human genome.scientificamerican.comNew Google DeepMind atlas could transform our understanding of genetic diseasesAlphaGenome Atlas predicts the effect of any single change in the fundamental structure of DNA 13410
Reposted by Michael OkunScientific American @sciam.bsky.social · 08/09/2026Some things, like pineapple on pizza and a weird cosmic particle detected in 2022, shouldn't be on Earth and yet they are. The former has no explanation, but scientists believe they may know how the photon survived the seemingly impossible journey.scientificamerican.comThis cosmic particle was never meant to reach Earth. Now scientists think they finally know why it didIn 2022 researchers detected a very odd photon from an enormous gamma-ray burst that should have been destroyed on its way to Earth 6599
Reposted by Michael OkunScientific American @sciam.bsky.social · 09/09/2026How introverted or extroverted you are may influence how you use AI.scientificamerican.comHow introverted or extroverted you are may influence how you use AIHow people interact with their inner and outer worlds may shape how they approach generative AI 3219
Reposted by Michael OkunLead-DBS @lead-dbs.org · 12/09/2026New publication using Lead-DBS: In this article by Kist et al., patients with OCD treated with subthalamic deep brain stimulation performed visual detection and confidence judgments with EEG, showing intact detection but poor... Check out the paper here 👇👇 doi.org/10.1038/s41398-026-04423-6 034
Michael Okun @michaelokun.bsky.social · 11/09/2026What resonates with me most about this paper is that it shifts the genetics conversation in Parkinson’s from simply “Who gets the disease?” to “Who progresses faster, and why?” Common loss-of-function variants in MC1R, ~30% faster motor progression in sporadic Parkinson’s. 030
Michael Okun @michaelokun.bsky.social · 10/09/2026Could carbon monoxide hold a clue to why smoking has been linked to a lower risk of Parkinson’s? New paper shows how higher exhaled CO levels were associated w/ a lower future risk of Parkinson’s disease, including among folks who never smoked. cutt.ly/Kyl4Fiu2 020
Michael Okun @michaelokun.bsky.social · 10/09/2026Germany has taken the bold step of recognizing Parkinson’s as an occupational disease when associated with long-term, frequent occupational pesticide exposure, an important acknowledgment that PD may sometimes be linked to preventable environmental exposures www.parkinsonstiftung.de/umwelt-und-p... 030
Michael Okun @michaelokun.bsky.social · 09/09/2026I had the opportunity to write this piece for The Conversation about something we often underestimate in Tourette syndrome: the extraordinary amount of effort many people expend trying to suppress their tics. theconversation.com/people-with-... 012
Michael Okun @michaelokun.bsky.social · 08/09/2026Could lumbar belts deserve a second look for low back pain? After 12 weeks, disability improved more in the lumbar belt group, and pain at rest and during activity also improved more than w/ usual care. Belts should perhaps not be dismissed simply because we were historically taught to avoid them. 000
Michael Okun @michaelokun.bsky.social · 07/09/2026We should all be making more noise: domperidone (Motilium), a peripheral dopamine antagonist commonly used in many countries, does not readily cross the blood-brain barrier and can be useful in Parkinson’s, yet it remains unavailable as a routinely FDA-approved prescription in the United States. 041
Michael Okun @michaelokun.bsky.social · 06/09/2026Four FDA-cleared blood-based assays are now available, including two cleared in August 2026, with p-tau217 emerging near the center of this new diagnostic pathway. But clinicians need to understand that ordering the test may be the easy part; managing what comes next will be harder. 010
Michael Okun @michaelokun.bsky.social · 05/09/2026What resonates with me about this study is that it moves the CTE conversation from symptoms recalled after death toward something far more rigorous: detailed neuropsychological testing performed during life lined up with what was actually found in the brain at autopsy. cutt.ly/LykT2EWg 050
Michael Okun @michaelokun.bsky.social · 04/09/2026Parkinson’s disease is not only costing lives and independence; it is costing Europe billions. Economic burden means the total financial impact of a disease, including medical care, lost productivity and unpaid caregiving. New paper: enormous and growing societal cost of PD across Europe. 030