Hedgehog signaling in vertebrates is transduced by the transmembrane protein Smoothened (SMO) on the primary cilium, but the underlying mechanisms remain unclear. This study shows that SMO and ciliary...

Chanda et al. uncover a circular RNA that links neuronal activity to mitochondrial function during synaptic plasticity. They show that circSamm50 sustains energy production needed for spine remodeling...

Here, the authors reveal that the mitotic motor KIF11 functions in postmitotic neurons as a microtubule-dynamics rheostat to regulate dendritic arborization. Additionally, they show how MCLID mutations impair KIF11 oligomerization, ATP hydrolysis, neuronal structure, and communication.

Here, the authors reveal that the mitotic motor KIF11 functions in postmitotic neurons as a microtubule-dynamics rheostat to regulate dendritic arborization. Additionally, they show how MCLID mutation...

The last year was marked by turmoil at science agencies and the administration’s stated desire to shrink the federal workforce.

The rewrite was done to speed up the construction of a new generation of nuclear reactors. Critics warn it could compromise safety and public trust.

In axons, α/β-spectrins, adducin, and actin-filaments assemble into a lattice underneath the plasma membrane, but mechanistic events leading to this membrane-associated periodic skeleton (MPS) are unc...

Handedness (i.e., the preference to use either the left or the right hand for fine motor tasks) is a widely investigated trait. Handedness heritability is consistently estimated to be 25%. After decad...

Microgravity conditions in space lead to bone loss in the weight-bearing bones of astronauts, with alterations in osteocyte mechanotransduction consid…

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs NOT-OD-25-138. NIH

ALT: harry potter is surrounded by a bunch of letters falling on the floor .

Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and ...

The FDA is hosting a workshop on reducing animal testing. The workshop is open to current FDA and NIH employees.

The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206

RNA-protein complexes coordinated by the long noncoding RNA Gas5 locally support synaptic remodeling.

Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...