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Elliott Weix

@weix.us
29 followers 39 following 4 posts

Studying biochemistry and mathematics. Yeast synthetic biology research in the Coyle Lab @ UW-Madison. More info at weix.us

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Reposted by Elliott Weix
Dr. Allyson Sgro @allysonsgro.bsky.social · 21/08/2026
Interested in how cells communicate and process information to work together? Love microscopy and seeing things no human has seen before for the first time? Finishing up your Ph.D. or position in early 2027? We are looking for an experimental postdoc to join the lab. Please reach out!
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UW–Madison Department of Biochemistry @uwbiochem.bsky.social · 03/08/2026
What can a microscopic organism in Lake Mendota teach us about cellular adaptation? The @cellraiser.bsky.social Lab is studying P. collini, a single-celled predator that reshapes its feeding structures to match changing conditions in its environment. Read the story: biochem.wisc.edu/2026/07/16/i...
biochem.wisc.edu
Investigating a Microscopic Predator in Madison’s Lakes
Researchers in the Coyle Lab have identified unusual growth patterns and their underlying biochemical mechanisms in a single-celled organism on the hunt.
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Elliott Weix @weix.us · 13/07/2026
Reminder that today (July 13) is the last day to submit comments on the OMB proposal. The proposed changes would allow arbitrary cancellation of grants and require review of scientific proposals by political appointees rather than experts in the field. www.regulations.gov/document/OMB...
regulations.gov
Regulations.gov
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UW–Madison Department of Biochemistry @uwbiochem.bsky.social · 08/07/2026
Undergrads @uwmadison.bsky.social build the skills & knowledge to jump into projects across a range of fields. In our Q&A series, you'll meet some biochem majors who serve in important roles. Recent grad Emma Kluge has started work @elilillyandcompany.bsky.social: biochem.wisc.edu/2026/06/24/u...
biochem.wisc.edu
Undergrad Profile: Emma Kluge
Recent graduate Emma Kluge was a researcher in Catherine Fox's lab, where she studied how DNA replication is impacted by heating up enzymes that are critical to the process.
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Scott Coyle @cellraiser.bsky.social · 02/07/2026
Had a blast putting this video abstract together with colleagues for @zjmaggiexu.bsky.social story in @currentbiology.bsky.social on how the "vampire cell" P. collini builds the perfect feeding trap 👀. Be sure to check out the full paper: www.cell.com/current-biol... www.youtube.com/watch?v=Ikzm...
youtube.com
A cellular vampire builds the perfect feeding trap / Curr. Biol., June 24, 2026 (Vol. 36, Issue 14)
YouTube video by Cell Press
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Scott Coyle @cellraiser.bsky.social · 24/06/2026
Congratulations to Coyle-Lab alum @born2raisecell.bsky.social (now in Kole Roybal's lab at UCSF) on being selected for this! Very well-deserved -- can't wait to see what you do next
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Scott Coyle @cellraiser.bsky.social · 24/06/2026
@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!
sciencedirect.com
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Jeff Martell @jeffmartell.bsky.social · 17/06/2026
Check out this awesome paper from @neugmonicaelena.bsky.social on a new family of nickel pincer enzymes! www.nature.com/articles/s41...
nature.com
Discovery and characterization of a nickel enzyme family that catalyses intermolecular hydride shuttling - Nature Chemistry
There is limited understanding of nickel-catalysed chemistry in nature. Now a bioinformatic pipeline reveals a structurally distinct family of nickel pincer nucleotide-dependent enzymes. Nickel pincer...
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edenchang.bsky.social @edenchang.bsky.social · 16/06/2026
Excited to share our new bioRxiv preprint! We introduce RIPPLE, a synthetic platform that couples reaction–diffusion signaling with protein condensation to generate tunable intracellular architectures. Grateful to @zjmaggiexu.bsky.social and @cellraiser.bsky.social. It’s been a rewarding journey.
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Scott Coyle @cellraiser.bsky.social · 16/06/2026
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
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Zhejing (Maggie) Xu @zjmaggiexu.bsky.social · 16/06/2026
Watching reaction-diffusion signaling couple to protein condensations feels like opening a new world of exotic subcellular spatial patterning 🌌 huge thanks to the evolving idea started from @edenchang.bsky.social and @cellraiser.bsky.social that make this journey possible and incredibly fun!
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Amy Weeks @amyweeks.bsky.social · 12/06/2026
Now online @pnas.org: We developed a simple, scalable, and accessible platform for deep profiling of phosphoeraser specificity using human phosphoproteome-derived peptide libraries (PhosPropels!) 🧪👩‍🔬https://www.pnas.org/doi/10.1073/pnas.2523183123
pnas.org
Phosphoproteome-derived peptide libraries for deep specificity profiling of phosphatases and phospholyases | PNAS
Protein phosphorylation is dynamically regulated by the opposing activities of phosphowriter enzymes (kinases) and phosphoeraser enzymes (phosphata...
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Amy Weeks @amyweeks.bsky.social · 12/06/2026
Make your voice heard here by July 13: www.regulations.gov/document/OMB...
regulations.gov
Regulations.gov
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Amy Weeks @amyweeks.bsky.social · 03/06/2026
Thanks to the Ono Pharma Foundation and The University of Chicago for supporting this amazing symposium! And congratulations to the Weeks lab's own Sopo Jalalishvili for winning a poster prize for her work on phospholyases! 👩‍🔬🧪@uwbiochem.bsky.social
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Avogadro Project @avogadro.cc · 01/04/2026
No fooling, Avogadro 2.0.0 is finally here! Rebuilt from the ground up: fast modern rendering, improved stability, designed for the next generation of molecular, biomolecule, and materials research & education. 🧪 ⚗️ avogadro.cc/install/ discuss.avogadro.cc #opensource #openscience #compchem
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Randall Munroe @xkcd.com · 02/04/2026
Home Solar xkcd.com/3226/
4-panel comic. (1) [Two people standing next to house with solar panels on roof. Person 2 has a black hat.] PERSON 1: Wait, you got solar panels? I thought you were against renewables. (2) PERSON 2: Oh, definitely. I hate the environment and want to harm it as much as possible. I’d *love* to have an oil furnace. (3) PERSON 2: But the technology just isn’t there and the cost is too high. I despise solar, but it makes more financial sense in my situation. (4) PERSON 2: But with the money I’m saving, I can buy and burn industrial waste in my yard to try to make up for it. PERSON 1: Ah, yeah, carbon onsets.
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 08/03/2026
Awesome representation from @uwmadscience.bsky.social at the @asbmb.bsky.social #ASBMB2026 meeting in DC! #ScienceServesUsAll
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Scott Coyle @cellraiser.bsky.social · 24/03/2026
Congratulations to my student Dennis Bolshakov and his coauthors @weix.us, Tommy, and @born2raisecell.bsky.social on making the cover of ACS Synthetic Biology! A great paper and an awesome cover 🥳 pubs.acs.org/doi/10.1021/...
The cover art, inspired by the classic Pink Floyd cover art from "The Dark Side of the Moon", depicts a white noise protein oscillation being filtered by a yeast expressing a specific synthetic circuit design into more precise, single-color waveforms. This visual echoes the noise-guided design strategies associated with Bolshakov et al.
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Elliott Weix @weix.us · 21/03/2026
Quick thing one can do for science! See also 5calls.org - calling your representatives is often even more effective than an email.
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David Bartel's Lab @bartellab.bsky.social · 19/03/2026
Our work on the E3 ligase mechanism of target-directed microRNA degradation is now published! Amazing collaboration with Brenda Schulman’s lab led by @jakobfarnung.bsky.social and @elenaslo.bsky.social, with special thanks to @wyppeter.bsky.social, Lianne Blodgett, and Daniel Lin! tinyurl.com/Z8TDMD
tinyurl.com
The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation - Nature
Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize AGO–miRNA–trigger...
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Viv @uberpantsmonkey.bsky.social · 20/03/2026
Spam musubi is divine
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Yeast Journal @yeast-journal.bsky.social · 27/01/2026
The deadline for the submission of papers to the special issue on the International Yeast Meetings of 2025 has been extended to 31 March. Papers should be connected to one of the meetings listed below. Hurry up and don't miss this chance! More information at: onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
Yeast Call for Papers: International Yeasts Meetings of 2025
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 19/02/2026
Evolution of error correction through a need for speed | Science www.science.org/doi/10.1126/...
science.org
Evolution of error correction through a need for speed
Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...
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Kirsty Wan @micromotility.bsky.social · 20/02/2026
Great to see our paper on light-intensity dependent swimming patterns in #Chlamydomonas out now in Phys Rev Lett. as an Editors' suggestion! With a nice commentary by @philipcball.bsky.social. Chlamy actively modulate the beat planes of their #cilia! journals.aps.org/prl/abstract... #protistsonsky
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Scott Coyle @cellraiser.bsky.social · 17/12/2025
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations! pubs.acs.org/doi/full/10....
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Dr. Allyson Sgro @allysonsgro.bsky.social · 02/01/2026
Thrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...
biorxiv.org
Memory from variability: Heritable short-term cellular memory emerges from stochastic biochemical reaction networks
Cells exhibit a mysterious form of selective heritable short-term memory, influencing outcomes as diverse as cell fate decisions in embryos and environmental responses in cancer cells and bacteria. He...
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Amy Weeks @amyweeks.bsky.social · 21/12/2025
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
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Interim Chancellor Eric M. Wilcots @uwchancellor.bsky.social · 09/12/2025
Congrats to Badger senior Evelyn Browning: a 2026 Marshall Scholar!👏 One of only 43 awardees in the country this year, she will investigate genetic variants related to neurodevelopmental conditions as a grad student at @cam.ac.uk & @sangerinstitute.bsky.social.
news.wisc.edu
Senior will take next step in science with prestigious Marshall Scholarship
UW senior Evelyn Browning will use the scholarship to continue her research of genetic variants.
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UW–Madison Department of Biochemistry @uwbiochem.bsky.social · 17/11/2025
Join us for Rohith Rajasekaran's (@born2raisecell.bsky.social) PhD thesis defense on Friday, Nov. 21! Rajasekaran's research was completed in the Coyle Lab (@cellraiser.bsky.social). More info: today.wisc.edu/events/view/...
today.wisc.edu
IPiB Thesis Review: Rohith Rajasekaran | UW–Madison Events Calendar
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Zhejing (Maggie) Xu @zjmaggiexu.bsky.social · 18/11/2025
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
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Scott Coyle @cellraiser.bsky.social · 18/11/2025
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
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purr.in.ink @purrinink.bsky.social · 14/11/2025
Not being a bit weird might be the weirdest thing of all 🐈‍⬛🤍
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UW–Madison @uwmadison.bsky.social · 11/11/2025
Barred owls are native to Wisconsin, but invasive out west. New UW–Madison research reveals they’re preying on at-risk species and disrupting entire ecosystems as they spread down the West Coast.
news.wisc.edu
The barred owl’s westward migration threatens other species and a whole ecosystem, UW researchers find
A new study shows that the invasive predator feeds on 29 species given special conservation status by federal and state governments.
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SmithLabUMBC @smithlabumbc.bsky.social · 06/11/2025
🚨Just in press @asbmb.bsky.social JBC!🚨 Alex & Chioma's paper detailing the interaction of Fe(II) with an intact membrane His kinase for the first time! Binding stoichiometry ✅ Fe(II) structure ✅ Direct observation of selectivity ✅ Signal transmission pathway ✅ Read more here: tinyurl.com/49wdkecu
tinyurl.com
The Pseudomonas aeruginosa Membrane Histidine Kinase BqsS/CarS Directly Senses Environmental Ferrous Iron (Fe2+)
Prokaryotic two-component signal transduction systems (TCSs) are widely utilized by bacteria to respond to their environment and are typically compose…
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 21/10/2025
Happy to share our latest work, led by Sierra Love and in collaboration with Melissa Jurica's lab at UCSC and @danglab.bsky.social at U. Minnesota-Twin Cities. This work was funded by the Edward P. Evans Foundation/EvansMDS. www.biorxiv.org/content/10.1...
biorxiv.org
A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators
Pre-mRNA splicing is a crucial process in eukaryotic gene expression, and splicing dysregulation has been linked to various diseases. However, very few small molecules have been discovered that can mo...
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 23/10/2025
Hi Everyone for the @asbmb.bsky.social 2026 annual meeting there is now a deferred payment option for federal employees and scientists impacted by the government shutdown. Information below and further details at the link. www.asbmb.org/annual-meeti...
asbmb.org
Abstracts
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UW–Madison @uwmadison.bsky.social · 16/10/2025
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
med.wisc.edu
Andrea Putnam awarded 2025 Packard Fellowship - School of Medicine and Public Health
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 06/08/2025
Hi structural biology friends @nucleosomepolice.bsky.social @kellythd-nguyen.bsky.social @sjorsscheres.bsky.social @bjgreber.bsky.social @cijilim.bsky.social @nogaleslab.bsky.social and many others...
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Gautam Dey @gautamdey.bsky.social · 07/08/2025
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social
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Carl T. Bergstrom @carlbergstrom.com · 08/08/2025
1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years. Today's executive order includes a provision that will obliterate both functions.
whitehouse.gov
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
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Amy Weeks @amyweeks.bsky.social · 18/07/2025
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
rdcu.be
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini
Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...
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Grace Lindsay @neurograce.bsky.social · 16/06/2025
I wrote a quick-start guide for people to replicate this across the country. It was, in our experience, a very effective way to get real action in a short amount of time. People are willing to talk to scientists! And when you provide everything, they are happy to contact their reps too. Try it!
docs.google.com
Postcard Drives for Science Instructions
Postcard Drive Instructions The main goals for this outreach are: A.) Get the public to (continue to) trust in and care about federally-funded science. B.) Get individuals to contact their Senators...
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UW–Madison Department of Biochemistry @uwbiochem.bsky.social · 17/06/2025
Congratulations to Rohith Rajasekaran, who was awarded a @uwmadisoncals.bsky.social Distinguished Graduate Fellowship! In the @cellraiser.bsky.social Lab, Rajasekaran focuses on the MinDE reaction-diffusion system. Learn more about his research: biochem.wisc.edu/2025/06/12/r...
biochem.wisc.edu
Rohith Rajasekaran of the Coyle Lab is Awarded Distinguished Graduate Fellowship
The year-long fellowship will support Rajasekaran's research into how to repurpose cellular systems that exist in nature to engineer new functions into cells.
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 18/06/2025
Terrifying but also good fodder for undergraduate biochemistry course homework and exams... www.pnas.org/doi/full/10....
pnas.org
Methane-powered sea spiders: Diverse, epibiotic methanotrophs serve as a source of nutrition for deep-sea methane seep Sericosura | PNAS
Methane seeps harbor uncharacterized animal–microbe symbioses with unique nutritional strategies. Three undescribed sea spider species (family Ammo...
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Kaçar Lab at UW-Madison @kacarlab.bsky.social · 27/05/2025
🧬 New preprint out today, years in the making! Rucker et al. traces ancient nitrogen fixation over 2 billion years through engineering & synthetic evolution. Supports reliability of N-isotope biosignatures on Earth & beyond. Congrats @hollyrucker.bsky.social! 🚀 www.biorxiv.org/content/10.1...
biorxiv.org
Persistent nitrogenase isotope signatures over two billion years of engineered evolution
Nitrogen isotope fractionation (e15N) in sedimentary rocks has provided evidence for biological nitrogen fixation, and thus primary productivity, on the early Earth. However, the extent to which molec...
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 28/05/2025
Listen to Karolin!
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Carl T. Bergstrom @carlbergstrom.com · 25/05/2025
Friendly amendment: May was brutal for the US. Trump sowed mass fear and confusion with a slew of illegal and unconstitutional orders. He faced no consequences other than being asked nicely to please stop, and so of course he continues to do destroy our country with this exact same playbook.
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Yeast Journal @yeast-journal.bsky.social · 22/05/2025
In the latest #Yeast research article of the series #FantasticYeasts, Pei-Jie Han, Feng-Yan Bai & team describe a new yeast species isolated from a Chinese forest: Saccharomycopsis yichangensis, that can prey on Saccharomyces cerevisiae and other yeasts 😲 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Saccharomycopsis yichangensis sp. nov., a Novel Predacious Yeast Species Isolated From Soil
Saccharomycopsis yichangensis sp. nov. occurs in soil from a subtropical forest in central China. This novel species is homothallic and produces asci containing four spheroidal ascospores, which can ...
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Carl T. Bergstrom @carlbergstrom.com · 22/05/2025
This is absolutely terrible news. With the shifting regulatory climate (i.e., antivax ratfuckery), Moderna has withdrawn their application for their eagerly anticipated COVID-flu combo vaccine. This vaccine offered better protection than getting each shot separately. h/t @merz.bsky.social
reuters.com
Moderna withdraws application for COVID-flu combination vaccine
Moderna said on Wednesday it has withdrawn an application seeking approval for its flu and COVID combination vaccine candidate after discussions with the U.S. Food and Drug Administration.
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Carl T. Bergstrom @carlbergstrom.com · 21/05/2025
I just left a comment. If you are concerned that RFK Jr.'s FDA chief Marty Makary is limiting the Novavax COVID booster to those over 65 or with underlying conditions, and may do the same for Pfizer/Moderna as well, consider leaving a comment as well.
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