Meyer-Schuman et al. interrogate MECP2 cis-regulatory elements (CREs) using a high-throughput reporter assay. This work identifies transcription factor binding sites that regulate MECP2 expression and...

Protein-structure prediction identifies a family of IL-1 protein homologues in Eumetazoa, which are characterized for expression, localization and function in sea lamprey and purple sea urchin.

Generation-by-generation ancestry tracking in hybrid stickleback shows that hybrid incompatibilities drive rapid removal of introgressed alleles following a tsunami.

Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form compact domains but short r...

Peer-reviewed research strengthens the case that wild animals - from dugongs to tigers - play active role in climate regulation.

A landmark collection of bat genomes reveals fresh clues about the evolution of one of the world’s most unusual groups of mammals.

An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry,…

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Applying deep-learning models to single-nucleus multi-omic sequencing data from flatworms and vertebrates, the authors propose that sets of sequence motifs defining cell type families are evolutionari...

The unusually high genetic diversity of MHC genes cannot be explained by heterozygote advantage alone because heterozygote advantage is not expected without some other driver of diversity.

The peopling of Remote Oceania involved some of humanity’s greatest expansions into the open ocean. Ancient DNA spanning the last 3,000 years from the Solomon Islands, Vanuatu, Fiji, and Tonga reveals...

Abstract. Despite publication of the Plasmodium falciparum reference genome over 20 years ago, one-third of its genes remain functionally unannotated, and

Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...

Nature Reviews Genetics, Published online: 31 July 2026; doi:10.1038/s41576-026-00996-6Computational metrics such as HLA evolutionary divergence offer new ways to quantify functional variation in antigen presentation. In this Comment, the authors discuss how population-scale genomics can benchmark these approaches and assess their potential as quantitative measures of human immune diversity.

The transition from hunter-gatherer to agricultural lifestyles is one of the landmarks in the history of human societies, but its phenotypic and immediate molecular consequences remain poorly understo...

By combining repository metadata, genotype-inferred ancestry, and manual curation of publications, Gallego Romero et al. demonstrate that public RNA-seq datasets are dominated by samples from high-inc...

Using spatial transcriptomics on longitudinal human cardiac biopsies, Amancherla, Oill and colleagues reveal marked cellular and molecular heterogeneity in transplanted hearts undergoing rejection, id...

Using spatial transcriptomics on longitudinal human cardiac biopsies, Amancherla, Oill and colleagues reveal marked cellular and molecular heterogeneity in transplanted hearts undergoing rejection, id...

Bird genomes are the smallest among amniotes; however, they remain challenging to assemble due to their structural complexity. This study presents a f…

Abstract. High-altitude hypoxia presents an extreme environmental pressure that challenges human survival, growth, and reproduction. Despite this challenge

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

Background: Small nuclear RNAs (snRNAs) are RNA components of the major and minor spliceosomes that play a core role in splice-site recognition and control of the splicing process. Variants in genes t...

Increasing nutrient diversity is expected to promote microbial diversity. This study shows that more complex environments can enhance resource uptake, intensify competition and lead to microbial biodiversity loss, challenging a central ecological assumption.

Nature Communications - How non-coding mutations in DNA contribute to phenotypes is a largely unresolved question. Here the authors integrate personal genomics and machine learning to identify...

The Andes hantavirus outbreak on a cruise ship unberthing from Ushuaia, Argentina, towards the Canary Islands and Europe has gained remarkable media attention in spring of 2026. Here, we want to spotlight the most important facts about Andes hantavirus and hantaviruses in general. We want to emphasize and inform about the worldwide circulation of diverse hantaviruses and the necessity to strengthen efforts in virus characterization and the development of effective countermeasures against hantaviruses in general.

We identified six genetic loci associated with neonatal lymphocyte-related traits through GWAS in 382 Hispanic cord blood samples and found that delivery mode and biological sex shaped immune cell com...

Ghost introgression from unsampled hominin lineages has emerged as an increasingly important component of human evolutionary history. Recent studies suggest that deeply divergent hominin lineages may ...

Using environmental DNA from 113 river systems, this study presents a unified analysis of global riverine fish biodiversity to examine how effectively environmental DNA captures multiple facets of bio...

Analyses of ancient DNA from hunter-gatherers near Lake Baikal in southeast Siberia around 5,500 years ago indicate that highly virulent Yersinia pestis emerged earlier than previously estimated, far from the next known cases of infection in Late Neolithic Europe.