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Jonathan Fenn

@jfennbio.bsky.social
187 followers 237 following 21 posts

Postdoctoral Research Associate at the University of Nottingham - looking at the epigenetic impacts of captivity and consequences for animal fitness.

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Jonathan Fenn @jfennbio.bsky.social · 06/08/2026
I was honoured to make a small contribution to this paper published today in Cell, detailing the first T2T genome assembly of the zebra finch, a crucial model species for neurobiology: tinyurl.com/tguttata
tinyurl.com
The complete genome of a songbird
Bird genomes are the smallest among amniotes; however, they remain challenging to assemble due to their structural complexity. This study presents a f…
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Science X / Phys.org @sciencex.bsky.social · 06/08/2026
The first complete songbird genome captures every zebra finch chromosome end to end, adding roughly 90 million missing DNA bases and revealing 2,710 hidden genes. Which may matter for vocal learning remains unresolved.
phys.org
First complete songbird genome exposes missing genes and chromosome architecture
The zebra finch is one of the best-studied songbirds and a model for understanding the biology and neuroscience of vocal learning.
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Jonathan Fenn @jfennbio.bsky.social · 26/06/2026
Here's the full schedule for the @evol-molly.bsky.social lab group at SMBE next week:
O’Connell Group at SMBE 2026

Jonathan Fenn – Wednesday 1st July 14:35-14:50
S22 Evolution of gene regulation: insights from novel molecular and statistical approaches
Coevolution of microRNAs and their gene targets leads to novel traits – insights from across the vertebrate tree of life.

Christopher Taylor – Wednesday 1st July 14:35-14:40
Open 8: Molecular and genome evolution 3
Convergent molecular evolution of thermal tolerance in mammals.

Alan Beavan – Poster Group A (Monday 29th June 18:00-20:00)
Board Number 313	Paper Number 1142	2nd floor: Arkaden 6
Constructive neutral evolution explains the emergence of specialised ribosomes in diverse eukaryotes.
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Jonathan Fenn @jfennbio.bsky.social · 26/06/2026
For anyone attending SMBE next week, I will be speaking about miRNA evolution and placental morphology in this Wednesday session 🧬
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Jonathan Fenn @jfennbio.bsky.social · 20/03/2026
...and the second on miRNA evolution. The deadline for both is 10th April. (2/2)
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Jonathan Fenn @jfennbio.bsky.social · 20/03/2026
Come and work with our group! 2 very cool PhD positions up for grabs - the first on stop codon readthrough...(1/2)
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Professor Mary J O'Connell @evol-molly.bsky.social · 27/02/2026
If you are looking for activities to do for the #BritishScienceWeek, take a look at our “How are proteins made?” from RiboCode sLoLa project. Designed for schools in the UK and Ireland, ages 7-11 (~KS2/Second to Fifth Class/P4-7). Download the free resources and enjoy:) ribocode.org/resources/
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Cameron Thrash @jcamthrash.bsky.social · 12/01/2026
PanForest: predicting genes in genomes using random forests academic.oup.com/bioinformati... #jcampubs
academic.oup.com
PanForest: predicting genes in genomes using random forests
AbstractMotivation. The presence or absence of some genes in a genome can influence whether other genes are likely to be present or absent. Understanding t
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Jonathan Fenn @jfennbio.bsky.social · 21/10/2025
It was a great privilege to be involved with this paper on a new T2T zebra finch genome, working on the miRNA side of things. Have a read of the preprint now!
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Journal of Molecular Evolution @jmolev.bsky.social · 20/08/2025
Talk from @jfennbio.bsky.social at #ESEB2025 on this work. I didn't catch the actual predictive accuracy in the talk - from the paper, I glean that it's >90%!
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Tilly S Scott @tillysscott.bsky.social · 19/08/2025
The day finished off strong with loads of great talks in the Genomics of Evolutionary Innovations symposium! I'm pleased to report that my talk went well ☺️ 🎨🖌️ #eseb2025 #eseb #esebconference @eseb2025.bsky.social @jfenn.bsky.social @timothyfuqua.bsky.social
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Jonathan Fenn @jfennbio.bsky.social · 17/08/2025
I have arrived in Barcelona for ESEB 2025! I will be talking about microRNA and the evolution of the mammalian placenta on Tuesday at 14:30 in Meeting Room 113 @eseb2025.bsky.social
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Jonathan Fenn @jfennbio.bsky.social · 17/08/2025
I have arrived in Barcelona for ESEB 2025! I will be talking about microRNA and the evolution of the mammalian placenta on Tuesday at 14:30 in Meeting Room 113 @eseb2025.bsky.social
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Max Planck Institute for Molecular Genetics @molgen.mpg.de · 03/07/2025
In Nature Genetics, @danielibrahim.bsky.social (MPIMG/BIH) and his team have developed a bioinformatic tool to identify evolutionary conserved regulatory regions of the genome that have transformed so much over time that their DNA sequences have changed completely. 👉 www.molgen.mpg.de/4927054
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Dr Christopher Taylor @mimicryin3d.bsky.social · 02/07/2025
Why do imperfect mimics (such as many hoverflies) exist? We created 3D printed replicas of flies, wasps and our own custom intermediates and then "asked" various predators what they thought of our 3D stimuli. Read all about it here: www.nature.com/articles/s41...
nature.com
Mapping the adaptive landscape of Batesian mimicry using 3D-printed stimuli - Nature
Birds have an excellent ability to learn to discriminate harmless insects from those that they mimic on the basis of subtle differences in appearance.
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Jonathan Fenn @jfennbio.bsky.social · 02/07/2025
Take a look at our work on miRNAs and their involvement with placental phenotypes. It's great to see this work finally see the light of day - huge thanks to everyone involved with the manuscript.
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Professor Mary J O'Connell @evol-molly.bsky.social · 30/06/2025
How did mammal placental diversity evolve? miRNAs play a significant role - indeed their repertoire is predictive of phenotype. Congrats to all: esp 1st author @jfennbio.bsky.social & all in @niamhforde.bsky.social group. Thanks to @ukri.org and @leverhulme.ac.uk. www.biorxiv.org/content/10.1...
biorxiv.org
Mammal placental phenotypes are predictable from microRNA repertoires.
Despite >100 million years of mammal diversification, similar placental morphologies have independently evolved multiple times, presenting a long-standing evolutionary puzzle: what genetic mechanisms ...
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Jonathan Fenn @jfennbio.bsky.social · 06/05/2025
It's great to see this work lead by @klarawanelik.bsky.social published - voles which are superspreaders of pathogenic bacteria have distinct gut microbiota: doi.org/10.1186/s425...
doi.org
Superspreaders have lower gut microbial alpha-diversity and distinct gut microbial composition in a natural rodent population - Animal Microbiome
The microbiome is well known to drive variation in host states (e.g. behaviour, immunity) that would be expected to modulate the spread of infectious disease—but the role of microbiotal interactions i...
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Jonathan Fenn @jfennbio.bsky.social · 06/05/2025
It's great to see this work lead by @klarawanelik.bsky.social published - voles which are superspreaders of pathogenic bacteria have distinct gut microbiota: doi.org/10.1186/s425...
doi.org
Superspreaders have lower gut microbial alpha-diversity and distinct gut microbial composition in a natural rodent population - Animal Microbiome
The microbiome is well known to drive variation in host states (e.g. behaviour, immunity) that would be expected to modulate the spread of infectious disease—but the role of microbiotal interactions i...
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Jonathan Fenn @jfennbio.bsky.social · 06/03/2025
Great to see this review of specialised ribosomes from Alan in our group, and his colleagues in RiboCode, published today. royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org
Specialized ribosomes: integrating new insights and current challenges | Philosophical Transactions of the Royal Society B: Biological Sciences
Variation in the composition of different ribosomes, termed ribosome heterogeneity, is a now well established phenomenon. However, the functional implications of this heterogeneity on the regulation of protein synthesis are only now beginning to be ...
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Jonathan Fenn @jfennbio.bsky.social · 08/01/2025
I will be speaking about miRNAs and placental phenotypes at PopGroup this afternoon at 14.15 in LT3 - come along if you're here!
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Jonathan Fenn @jfennbio.bsky.social · 06/12/2024
miRNA back in the news!
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Jonathan Fenn @jfennbio.bsky.social · 04/12/2024
When I'm not doing research, I occasionally write about video games, and in this piece that just went up @unwinnable.com I try to combine the two. Specifically, I look at the difficulties of simulating the natural world in a game. Have a read if that sounds at all interesting!
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Magdalena Skipper @magdalenaskipper.bsky.social · 22/11/2024
‘A place of joy’: why scientists are joining the rush to Bluesky For me, it certainly feels good to be here! @natureportfolio.bsky.social @bsky.app www.nature.com/articles/d41...
nature.com
‘A place of joy’: why scientists are joining the rush to Bluesky
Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.
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Jonathan Fenn @jfennbio.bsky.social · 14/10/2024
In my ongoing quest to leave Twitter, I'm hoping use this account for sharing my research, and publicising the work of the O'Connell lab here at the University of Nottingham. I'm looking at the evolution of microRNA - the discovery of which recently earned a Nobel Prize! tinyurl.com/552ph6xh
tinyurl.com
Nobel Prize goes to microRNA researchers
US scientists Victor Ambros and Gary Ruvkun helped explain how genes work inside the human body.
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