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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/09/2026

Learn more about our next two Variant Effects Seminar speakers and their research. Mariano Martín Gomez and Seulki Kwon will present on October 6 (16.00-1700, UTC). Learn more about the seminar series and how to join their talks at www.varianteffect.org/seminar-seri...

The composite image shows headshots of the next two speakers of our Variant Effects Seminar Series (VESS) - Mariano Martín Gomez (left) and Seulki Kwon (right).

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/09/2026

Are you an AVE member? Membership is open to anyone invested in creating comprehensive variant effect maps. Joining gives you access to: ☑️ Newsletters ☑️ Community Slack channels ☑️ Literature, resources & technical expertise ☑️ Collaboration & career opportunities Join today: tinyurl.com/3smfcaks

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 22/09/2026

Join us on October 6 for another edition of our early career seminar series. The seminar will feature @marianomartin.bsky.social (Institute for Bioengineering of Catalonia) and Seulki Kwon (Broad Institute). More information and joining instructions: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 17/09/2026

We're delighted that Nobel Laureate David Baker, Director of the Institute for Protein Design at the University of Washington, will deliver a keynote address at the Mutational Scanning Symposium, next June. Event registration opens soon. Learn more: tinyurl.com/3x8d5rev Image: Christopher P. Michel

The image shows MSS keynote speaker, Dr David Baker. He is holding a multicoloured protein model towards the camera. Image credit: Christopher P. Michel

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 16/09/2026

Our YouTube channel is a great resource that incudes: ✅ Deep mutational scanning principles ✅ Functional evidence workshops ✅ Mutational Scanning Symposia ✅ Early career seminars ✅ Virology Interest Group talks and more. Search by presenter, topic or series: tinyurl.com/2e4rbcm3

The image is a screenshot of the Atlas of Variant Effects YouTube homepage.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 10/09/2026

Get the latest research from our Virology Interest Group on our YouTube channel: youtu.be/XNu2ejij_vo?... This month's talk was given by Caroline Langley (Bonilla Lab, Rockefeller University) on how strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.

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“Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins”

YouTube video by Variant Effects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 09/09/2026

If you missed last week's Variant Effects Seminar, you can now find the presentations on the VESS playlist on our YouTube channel. Catch up with the excellent talks from Sergio Garcia Busto and Kortni Kindree whenever it works for you. See the VESS playlist: youtu.be/24n8i78STPQ?...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/08/2026

If you're interpreting functional assays for clinical use, check out this resource from members of our ClinGen/AVE Functional Data Working Group. Get more information and download the presentation: www.varianteffect.org/clinical-app... Read the preprint: www.medrxiv.org/content/10.6...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/08/2026

Join us next week for the Variant Effects Seminar! Our September speakers are Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto) Learn more about our speakers, their work and how to join the seminar: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/08/2026

Have you listened to the Variants and Us (VUS) podcast yet? Now into its second season, the podcast focuses on the basic and translational science necessary to map the effect of variants in disease and rare disease. Listen to all episodes here: www.varianteffect.org/podcast/

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 17/08/2026

Our next Variant Effects Seminar is on September 1. Join Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto) and explore their research. Learn more about our speakers' work and how to join the seminar: www.varianteffect.org/seminar-seri...

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Reposted by Atlas of Variant Effects Alliance

Fritz Roth @fritzroth.bsky.social · 06/08/2026

🧪 One small step towards a complete atlas of human sequence variant effects, a giant leap for figuring out which variants in the Autoimmune Regulator (AIRE) protein are pathogenic, and some baby steps towards understanding the AIRE protein @varianteffect.bsky.social

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 04/08/2026

Don't forget, we'll be live later for our Variant Effects Seminar. Today's talk is with @sarahgurev.bsky.social. Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/07/2026

Our Variant Effects Seminar Series returns next Tuesday, August 4! Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'. Discover Sarah's work and get the event joining info: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 28/07/2026

Some of our Virology Interest Group have authored a review of the recent technological & conceptual advances in the deep mutational scanning methods being applied to virology. Also covered are the insights these advances are yielding & suggestions for future studies. Read now: tinyurl.com/84dcy96z

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Scanning the horizon: deep mutational scanning approaches in virology | Journal of Virology

The development of deep mutational scanning (DMS) approaches has led to a fundamental shift in our ability to connect viral genotype and phenotype (1) and accelerated our understanding of viral evolut...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 28/07/2026

As our Variant Effect Seminar Series (VESS) returns, we caught up with two of our earliest speakers, Mafalda Dias & Jonathan Frazer. Now group leaders at the Centre for Genomic Regulation (CRG) in Barcelona, we explore the role of VESS in their journey. Read their interview: tinyurl.com/m4ncw2nf

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 23/07/2026

Mark your calendars for the next instalment of our Variant Effects Seminar Series. 🗓️ On August 4, Sarah Gurev will be our sole speaker, with her extended presentation, 'Toward reliable viral mutation effect prediction for pandemic preparedness'. More info: tinyurl.com/4ms3mmzy

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20/07/2026

You can still register for, 'Unmasking the Genome: Integrating WGS, AI and Functional Genomics', from 1-4 September at the University of Exeter, UK. The workshop is for all researchers working at the leading edge of genomic science. 🧬 Get the programme and register now: tinyurl.com/4vbrp63p

tinyurl.com

Unmasking the Genome: Integrating WGS, AI and Functional Genomics - UK Human Functional Genomics Initiative

Unmasking the Genome is a four-day advanced workshop designed for researchers working at the leading edge of genomic science. This programme brings together expertise from Google DeepMind, leaders in ...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 16/07/2026

The new publication by members of the Atlas of Variant Effects Clinical Variant Interpretation working group provides guidance for combining data from multiple MAVEs to strengthen the functional evidence for clinical variant classification. Read now: tinyurl.com/yn6bkhhn

link.springer.com

Combining multiplexed functional data to improve variant classification - Genome Medicine

Background With the surge in the number of variants of uncertain significance (VUS) reported in ClinVar in recent years, there is an imperative to resolve VUS at scale. Multiplexed assays of variant e...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 15/07/2026

The latest episode of the Variants and Us (VUS) podcast explores how MAVEs are made with two scientists (@kmatreyek.bsky.social and @gregfindlay.bsky.social) that have transformed the generation of phenotypic data for thousands of variants simultaneously. Listen now: tinyurl.com/3kv774ee

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Inside the toolbox: how MAVEs are made

Variants and Us (VUS) Podcast · Episode

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 13/07/2026

Our Variant Effects Seminar Series (VESS) is taking a break this month, but will be back on August 4 with an extended presentation from @sarahgurev.bsky.social, 'Towards reliable viral mutation effect prediction for pandemic preparedness'. Discover VESS and all speakers: tinyurl.com/4atzepeb

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 07/07/2026

Our Variant Effects Seminar Series (VESS) is organized and led by a committee of early career scientists. We asked Priyanka Bajaj and @ohannab.bsky.social about their experiences on the VESS committee, as they depart for new adventures in variant science. Read now: tinyurl.com/lifeaftervess

Composite image of Priyanka Bajaj (left) and Ohanna C. L. Bezerra (right)

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 01/07/2026

Missed Abbye McEwan's excellent introduction to MAVE technology? It's now available on YouTube: www.youtube.com/watch?v=FeUp... Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.

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VSN presents Beyond the VUS Using MAVE Data to Inform Clinical Variant Classification

YouTube video by Variant Scientists Network

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/06/2026

Did you know you can find all the Variant Effects Seminars on the AVE YouTube channel? Established in 2021, the seminar series reached its 100 speaker milestone last month. So, there are plenty of great talks to choose from. Find your next watch: tinyurl.com/AVE-VESS #AtlasOfVariantEffects

Screen grab of the Variant Effects Seminar Series (VESS) playlist on the Atlas of Variant Effects (AVE) YouTube Channel.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 25/06/2026

Why should you attend MSS 2027? We asked PhD student Rebeca Olvera-León about her experiences at the last four MSS events, and found out what she was most looking forward to for MSS 2027: bit.ly/4eHgiJz Tell us, what do you hope is on the program for MSS 2027?

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/06/2026

We are delighted that Jay Shendure will be a keynote speaker at MSS 2027. He says, "It's phenomenal to see the community that AVE has grown in to, and the impact that it's having. I'm excited to have the opportunity to share some perspective and our latest work." www.varianteffect.org/mss2027/

Dr Jay Shendure stands, arms folded and smiling, with his back to the bench, in his laboratory. Photo courtesy of Ron Wurzer.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/06/2026

It's exactly 1 year until the 10th anniversary MSS 2027 in Seattle! MSS unites the functional genomics community, fostering field-defining discussions and collaborations. Co-organizer, Doug Fowler, PhD, discusses the event: bit.ly/4wbDzKV #VariantEffect27 #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 17/06/2026

Don't miss Abbye McEwen's deep dive into interpretation of variants of unknown significance (VUS) - happening today (12.00 pm ET / 9.00 am PT / 5.00 pm BST). Join here: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 15/06/2026

This Wednesday, are you ready to go beyond the VUS and learn more about using multiplexed assays of variant effects (MAVEs) to inform clinical variant classification? It's free to sign up: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #VUS #MAVE #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 12/06/2026

At last week's Variant Effects Seminar (VESS), @eag91.bsky.social discussed disentangling the biophysical effect of missense variants using protein dark energy. If you missed it, you can now watch it on our YouTube channel at a time to suit you. ⏯️ youtu.be/je5XosFTLPY

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Disentangling the biophysical effect of missense variants using protein dark energy - E. A. Galpern

YouTube video by Variant Effects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 11/06/2026

Last week our Variant Effects Seminar Series (VESS), reached its 100th speaker. Are you in our gallery? Let us know! VESS is led by and exists for early career scientists, enabling them share their work on interpreting human genetic variation. Learn more: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 09/06/2026

MAVEs are transforming how labs evaluate genetic variants, providing functional evidence at scale. Join Dr Abbye McEwen for an introduction to MAVEs and to learn how these datasets may help resolve variants of uncertain significance. Register free: bit.ly/3Seq0LL #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 08/06/2026

@tylernstarr.bsky.social of the University of Utah recently presented for the AVE Virology Interest Group on his latest research into SARS-CoV-2 variants using deep mutational scanning. Watch now and subscribe: youtu.be/hQ6ArFcOwPA #AtlasOfVariantEffectsAlliance

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“Deep mutational scanning of recent SARS-CoV-2 variants" - Tyler Starr

YouTube video by Variant Effects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 02/06/2026

Happening today – don't miss out! Join here: www.varianteffect.org/seminar-seri... at ⏰ 9.00 (Pacific) ⏰ 12.00 (Eastern) ⏰ 17.00 (BST) ⏰ 18.00 (CEST)

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 01/06/2026

Join us tomorrow for a special VESS seminar, as we mark our 100th speaker milestone with a talk from postdoctoral researcher, Ezequiel Galpern. We also have some special guests, as we look to the next 100 speakers! Joining info: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

Milestone at the mic: Celebrating 100 VESS speakers. The image shows celebratory green fireworks, the name and title of presenter (Ezequiel A Galpern) and a joining link and QR code.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/05/2026

Join us, next Tuesday as we mark 100 speakers in VESS! After Ezequiel Galpern's presentation we will celebrate our first 100 speakers and a look to the future of this fantastic early-career seminar series. See you there ➡️ www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20/05/2026

Our Variant Effect Seminar Series is marking a milestone! Join us on Tuesday, June 2, for our 100th speaker, Ezequiel Galpern. Plus, special VESS guests, as we celebrate and look forward to the next 100 speakers! Join here: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

The image shows celebratory fireworks in shades of green and has the text "Milestone at the mic: 100 VESS speakers. June 2, 2026. It also details the presenter (Ezequiel Galpern) with a photo and title of his talk.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 18/05/2026

Both talks from the May episode of the Variant Effects Seminar Series (VESS) are now available to watch on our YouTube channel ⏯️ bit.ly/4ud02Xa. Catch up with Thea Klarsø Schulze and Jerome Freudenberg's presentations anytime! #Genomics #VariantInterpretation #AtlasOfVariantEffects

May VESS flier with images of both speakers and their presentation titles.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 14/05/2026

Catch up on all 3 days' talks from the Mutational Scanning Symposium (MSS) 2026 on our YouTube channel ⏯️ bit.ly/4diP7FD Whether you're watching for the first time or revisiting a favorite talk, there's something insightful to enjoy! #VariantEffect26 #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 13/05/2026

You can now find the Day 2 presentations from the MSS 2026 over on our YouTube channel. ⏯️ bit.ly/4tzo9hQ The final day's talks will be live soon, so watch this space! #VariantEffect26 #Genomics #DeepMutationalScanning #FunctionalGenomics #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 12/05/2026

Day 1 presentations from the Mutational Scanning Symposium (MSS) 2026 are now available on our YouTube channel: www.youtube.com/playlist?lis... Check back again soon for days 2 and 3 of MSS 2026! #VariantEffect26 #AtlasOfVariantEffects

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MSS26 Day 1 - YouTube

Presentations from the Mutational Scanning Symposium (MSS) 2026, held March 25-27 in Melbourne, Australia.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 05/05/2026

Tomorrow, our Variant Effect Seminar speakers will be covering various aspects of the modeling of variant effects. They hope you can join them! Details here: www.varianteffect.org/seminar-seri... #Genomics #VariantInterpretation #DeepMutationalScanning #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/04/2026

🧬 There's still time to submit your application to join the Variant Effect Seminar Series (VESS) Organizing Committee - but not much. Applications close tomorrow - April 30! ℹ️ Learn more and apply👇 forms.gle/vdLh3mu9Fuid... #VESS #VariantEffects #Seminar #Genomics #EarlyCareer

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/04/2026

Next week's Variant Effect Seminar: Thea Klarsø Schulze will discuss predictive models of variant effects on protein abundance. Jerome Freudenberg will cover modeling of variant effects in FACS-based deep mutational scans with Lilace. www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 21/04/2026

May's Variant Effect Seminar features Thea Klarsø Schulze of the MRC Laboratory of Molecular Biology, Cambridge, UK and Jerome Freudenberg from the Pimentel lab at UCLA, USA. Bookmark the event in your calendar: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20/04/2026

You can watch all our Variant Effects Seminars on YouTube. Yuta Yamamoto (Ashely lab, Stanford University, USA) delivered April's second talk on decoding genetic variants associated with hypertrophic cardiomyopathy using scalable functional genomics. Catch up now: youtu.be/w9dfXdETqNs?...

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Scaled multidimensional assays of variant effect for hypertrophic cardiomyopathy - Yuta Yamamoto

YouTube video by Variant Effects

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