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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀

@edrybicki.bsky.social
4K followers 321 following 24K posts

Semi-retired biotechnologist and virologist, interested in making vaccines, lover of 70s rock and hard SF. And good red wine. Posts are both personal and professional, and may include music and/or strong opinions. And possibly zombies.

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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Gareth L. Powell / G.L. Powell @garethlpowell.bsky.social · 12h
A big thank you, from me to you
A picture of Gareth standing by a window with the caption ThanksA pile of Gareth’s books with the caption “for reading my books”A picture of a laptop, with the caption and for following and supporting me onlineA picture of a cup of coffee and a notebook on a café table with the caption I couldn’t do this without you
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 12h
@almaalexander.bsky.social Hey Alma: you know it's almost exactly 15 years since you alerted me on Xwitter to an online furore about a certain Story? How time flies...! 😳🙄
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Joe Noonan @joenoonan.bsky.social · 28/09/2026
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Will Ratcliff @wcratcliff.bsky.social · 28/09/2026
New paper out with @kaylastoy.bsky.social: academic.oup.com/evlett/advan...
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
The Journal of Infectious Diseases @jidjournal.bsky.social · 29/09/2026
HPV33 and HPV45 sublineage antigenicity defined by neutralizing antibodies elicited during natural infection ✅ Just Accepted 🔗 bit.ly/4yVmx50
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Chise @sailorrooscout.bsky.social · 28/09/2026
The study has been published in Nature. YES, it is PEER-REVIEWED. • www.nature.com/articles/s41... 🧪🧵⬇️
ABSTRACT
A key challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds.
Although natural products produced by fungi and bacteria, particularly actinomycetes, have been the
years, they have fallen out of favour owing to the frequent rediscovery of known drug scaffolds. The current perception is that antibiotic-producing actinomycetes have been over-mined and possess little novelty left to yield.
Here we demonstrate that by using improved fractionation approaches that enrich previously overlooked minor products, even well-studied strains of antibiotic-producing actinomycetes can provide new chemical scaffolds with unique modes of action. By fractionating a library of natural product extracts from soil bacteria, we show that Streptomyces rimosus, the source of the well-known antibiotic oxytetracycline, produces a cyclic depsipeptide antibiotic that we call manikomycin.
Manikomycin can kill multidrug-resistant
binds in the E-site of the large subunit of the bacterial ribosome, preventing entry of the 3' end of the tRNA into the E-site and effectively hindering the translocation step of protein synthesis in a sequence-context-specific manner.
Manikomycin is the first antibacterial agent, to our knowledge, to target the critical but underexplored E-site in the large ribosomal subunit, highlighting its value as a lead for developing new antibiotics.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 22h
Mixed feelings about this. OK, my sister-in-law Carolyn Williamson is first author, but seriously: who thought this WASN’T going to happen? Also, maintaining Ab concentrations high enough to mop up HIV seems a highly impractical form of prophylaxis - not to mention expensive.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Lacie 💖 @cooks4luv.bsky.social · 29/09/2026
It's Tuesday which means Lacie's #MorningCafe opens at 7 am tomorrow. I'm having a picnic providing an eclectic breakfast buffet of #music from the #sixties #seventies and more! Get your #HumpDay off to an energetic start. #listen #live www.2rrr.org.au
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Carl Zimmer @carlzimmer.com · 28/09/2026
Bundibugyo outbreak tops 8,000 confirmed cases as disease remains out of control apnews.com/article/cong...
apnews.com
Congo's Ebola outbreak tops 8,000 confirmed cases as disease remains out of control
The number of confirmed Ebola cases in Congo has surged past 8,000 as the country struggles with a shortage of health workers. The new statistics were released Sunday.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Carl Zimmer @carlzimmer.com · 28/09/2026
The human genome is part virus. And here's a virus that's part human, having picked up a human gene about 100,000 years ago. My story here: nyti.ms/4hRKNPC
nyti.ms
This Virus Stole a Human Gene and Won’t Let Go of It (Gift Article)
Scientists have found a human gene lurking in a virus that causes skin infections. It may be using our own DNA to infect us.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Nature Microbiology @natmicrobiol.nature.com · 28/09/2026
Out Now! Convergent receptor use at the coronavirus One Health interface #MicroSky
go.nature.com
Convergent receptor use at the coronavirus One Health interface
Nature Microbiology, Published online: 28 September 2026; doi:10.1038/s41564-026-02491-4Two independent studies identified host species-specific aminopeptidase N as the entry receptor for hedgehog merbecoviruses, revealing convergent receptor use with alphacoronaviruses, but through a distinct binding site. Defining barriers to receptor use across species could help predict future host jumps and emerging transmission risks at the wildlife–veterinary–human interface.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Microbes.Info @microbesinfo.bsky.social · 28/09/2026
🦠📚 Scientists have created a large library pairing #bacteria with the #viruses that infect them, providing a resource for exploring #Phages and their potential #biotechnology applications. #Microbes #Bacteria #Phage #Biotech #Microsky via @sciencex.bsky.social phys.org/news/2026-09...
phys.org
A 'library' of bacteria-killing viruses: Harnessing the power of phages
An estimated 38 trillion bacteria live in the human body—and only a small fraction are harmful to our health. However, the harmful ones can cause serious illness, especially when they develop…
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Helen Lazear @lazearlab.bsky.social · 28/09/2026
www.science.org/content/arti...
science.org
Ancient sheep virus found hiding in medieval parchment
Newly recovered sheeppox sequences reveal when and how the virus emerged
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Health Policy Watch - Global health news reporting @healthpolicywatch.bsky.social · 28/09/2026
Three years after COVID-19, pandemic preparedness is losing momentum. A 20-country Univ. of Singapore - @thelancet.com study finds many systems failed those most at risk — and offers a blueprint for protecting people better next time. ✍️ @kerrycullinan.bsky.social 📖 ⬇️ & 🔁🙏
healthpolicy-watch.news
As Global Pandemic Approach Flounders, Experts Offer Blueprint To Protect All Citizens - Health Policy Watch
It’s been barely three years since the COVID-19 pandemic ended, yet many world leaders appear to have little appetite for pandemic-proofing. Ahead of the UN
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Nigel Bell 🍉 @nigel63.bsky.social · 28/09/2026
It speaks for itself... youtube.com/shorts/nyeAW...
youtube.com
From 37 years ago
Duet with: https://www.tiktok.com/@truth.teller843 Original video: ...
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Tom Gauld @tomgauld.bsky.social · 27/09/2026
Author Simulator. My latest books cartoon for @theguardian.com
Title: Author Simulator 

Level 1: Get to desk and begin! (Platform video game-style image of an author jumping from a block onto  a cloud with desk and computer) Result: success!

Level 2: Press on despite distractions! (Author typing as the desk/clod moves past a ghost and a spider) ) Result: success!

Level 3: Deliver manuscript to editor! (Author jumping over fire pit onto platform where editor waits) Result: success!

Level 4: Accept minor criticism! (Author lying ded in fronto of editors desk) Result: better luck next time!

Along the bottom are controls for:
 Left right jump crouch read write nap coffee
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 28/09/2026
Putting the boot in, eh, Wordle 1,927 5/6? ⬜⬜⬜⬜🟨 ⬜⬜🟩🟩⬜ ⬜⬜🟩🟩🟩 ⬜⬜🟩🟩🟩 🟩🟩🟩🟩🟩
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Paul Cornell @paulcornell.bsky.social · 28/09/2026
Lovely article about Saucer Country! screenrant.com/best-sci-fi-...
screenrant.com
X-Files Meets The Diplomat In This 21-Part Sci-Fi Masterpiece
The spooky UFO mythology of The X-Files meet the political intrigue of The Diplomat in a sci-fi masterwork that pays off its premise like few others.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 28/09/2026
Been known for some time, but good that the news is getting out there!
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Evgenii Protasov @evgenii-protasov.bsky.social · 28/09/2026
Two coinfecting archaeal viruses provide insights into virus-virus interactions #virology #virus #archaea #MicroSky doi.org/10.1038/s420...
doi.org
Two coinfecting archaeal viruses provide insights into virus-virus interactions - Communications Biology
Communications Biology - Two coinfecting archaeal viruses provide insights into virus-virus interactions
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 28/09/2026
Free PREDICTED structures…need verification before they’re any use at all!
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 27/09/2026
Damn, Wordle 1,926 5/6?? Going with the archaic stuff again? Like the John B? ⬜⬜⬜⬜⬜ ⬜🟨🟩⬜🟨 🟩⬜🟩🟩🟩 🟩⬜🟩🟩🟩 🟩🟩🟩🟩🟩
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Open Forum Infectious Diseases @ofidjournal.bsky.social · 26/09/2026
Delayed seasonality but consistent age burden: RSV epidemiology pre-, during and post-COVID-19 pandemic on the Kenyan Coast (2008-2026) ✅ Just Accepted 🔗 bit.ly/4ySoOOe
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Ryan Hisner @ryanhisner.bsky.social · 26/09/2026
Phenomenal 🧵 (& paper) about why Omicron is less efficient at infecting the lung than previous variants. Initial ideas on this were proven wrong, & it's been an utter mystery since. Stuart, doing work on one else is doing, has largely explained it & revealed vital aspects of the SARS-2 life cycle.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Dr Noor Bari @njbbari3.bsky.social · 26/09/2026
Climate change is an obvious cause of dengue outbreaks in new locations and with increased size. BUT DID YOU KNOW THIS? www.frontiersin.org/journals/imm...
frontiersin.org
Frontiers | Dengue–SARS-CoV-2 interactions: immune crosstalk, variant emergence, and clinical outcomes
This review aims to provide an overview of dengue–COVID–19 co-infection, emphasizing recently described immunological, genomic, and eco-epidemiological inter...
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 26/09/2026
Good word, Wordle 1,925 4/6! ⬜⬜⬜🟨⬜ ⬜⬜🟩🟨⬜ 🟩🟩🟩⬜⬜ 🟩🟩🟩🟩🟩
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Science Magazine @science.org · 25/09/2026
Ancient viral warfare could be at the root of modern class 1 CRISPR bacterial defense systems. Learn more in a new #SciencePerspective: scim.ag/46rOANl
scim.ag
A viral origin for RNA-guided immunity
Ancient viral warfare could be at the root of modern class 1 CRISPR bacterial defense systems
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Cedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026
Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n
science.org
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Colin Carlson @colincarlson.bsky.social · 25/09/2026
Here's the link to his essay. I'm going to address this in four parts: (1) The basic scientific error a fact-checker should have caught; (2) Incompatibility with existing science; (3) How our new paper challenges other supporting evidence; and (4) The consequences. www.nytimes.com/2026/09/22/s...
nytimes.com
The Urgent Mystery of Where Viruses Hide (Gift Article)
Some viruses appear to vanish when outbreaks dissipate, only to emerge again. Scientists don’t always know which animals they lurk in — and how to stop them from spilling back over.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Evgenii Protasov @evgenii-protasov.bsky.social · 25/09/2026
A One Health perspective on mobile genetic elements and associated antibiotic resistance genes in non-human A. baumannii #microbiology #OneHealth #microbiome #MicroSky @asm.org journals.asm.org/doi/10.1128/...
journals.asm.org
A One Health perspective on mobile genetic elements and associated antibiotic resistance genes in non-human A. baumannii | Applied and Environmental Microbiology
Antimicrobial resistance (AMR) is one of the major global public health threats. In recent decades, Acinetobacter baumannii has become one of the most significant multidrug-resistant (MDR) bacteria in hospital settings (1, 2). Since 2017, the World Health Organization has classified carbapenem-resistant A. baumannii as a critical-priority pathogen, a status that remains in the most recent update in 2024, which reflects the urgent need for new antibiotics against this bacterium (3, 4). A. baumannii is a frequent cause of nosocomial infections, primarily affecting patients in intensive care units (ICUs), immunocompromised individuals, patients using medical devices (such as catheters), and those with underlying diseases (5).
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Alexander Harms @aharms485.bsky.social · 25/09/2026
The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Nature Microbiology @natmicrobiol.nature.com · 25/09/2026
Out Now! Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ #MicroSky
go.nature.com
Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ
Nature Microbiology, Published online: 25 September 2026; doi:10.1038/s41564-026-02455-8HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing) is a transposon-insertion sequencing method for phages that systematically links their genes to selectable phenotypes.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Nature Microbiology @natmicrobiol.nature.com · 25/09/2026
Out Now! Defining the essential genome of diverse phages with phage Tn-seq #MicroSky
go.nature.com
Defining the essential genome of diverse phages with phage Tn-seq
Nature Microbiology, Published online: 25 September 2026; doi:10.1038/s41564-026-02486-1Phage Tn-seq uses Tn5 transposon mutagenesis with anti-CRISPR-based selection and deep sequencing as a method to generate unbiased, genome-wide mutations across diverse phages
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 26/09/2026
I have been peripherally involved in looking for phages hypersaline environments in Namibia, where there was a connection between local seawater and inland salt deposits - due to windblown spray transported inland in fog.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 25/09/2026
Home!! Surrounded by dogs 😍 Mainly because the daughter left two here, and it's their supper time 🙄
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 25/09/2026
Some stupendous scenery - instant geogasm for those who know - and spring flowers, near Montagu on Route 62.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 25/09/2026
Taken up landscape gardening, have you, Wordle 1,924 4/6? “Put a nice little one in over there…”?! ⬜⬜⬜🟨⬜ 🟨⬜🟨⬜🟩 ⬜🟩⬜🟩🟩 🟩🟩🟩🟩🟩
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Crawford Kilian @crof.bsky.social · 24/09/2026
www.nature.com/articles/d41...
nature.com
Gravitational tug-of-war inside Earth is changing the length of our days
A battle of forces, driven by the motion of Earth’s core, can explain small variations in the planet’s rotation, study finds.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Paul Cornell @paulcornell.bsky.social · 24/09/2026
My company @cosmiclighthouse.co.uk is putting out a Murderbot graphic novel, All Systems Red, with a new @marthawells.com Mb short story too! @ericaschultz42.bsky.social @garyerskine.bsky.social @stillwintercraft.bsky.social @simonbowland.bsky.social ! www.kickstarter.com/projects/cos...
kickstarter.com
Coming soon: Murderbot: The First Graphic Novel | Multi-award-winning SF!
The official adaptation of the international bestselling multi-award-winning ALL SYSTEMS RED, part of The Murderbot Diaries series.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 24/09/2026
Sunset on a sandstone wall at the Baron van Reede Guesthouse, Oudtshoorn. Nice place!
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 24/09/2026
This time, a proper glass for a good wine. Late afternoon in Oudtshoorn, one sleep from home!
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 24/09/2026
Lunch in a quaint place in Willowmore, Eastern Cape. Afrikaanse kos hier! 😄
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Harmit Singh Malik @harmitmalik.bsky.social · 24/09/2026
I see that @anthropic.com is now competing with PhD students in Biology/Bioengineering labs, whose biggest worry until now was being inevitably scooped by the Feng Zhang and Jennifer Doudna labs. Very different from Wild West days of RT discoveries in my PhD. www.anthropic.com/news/claude-...
anthropic.com
Claude discovers a novel enzyme system
In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.
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Reposted by Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀
Cell - a Cell Press journal @cp-cell.bsky.social · 23/09/2026
Now online! Direct cell-to-cell transmission of retrotransposons
dlvr.it
Direct cell-to-cell transmission of retrotransposons
Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 23/09/2026
The way he led them out of Egypt, eh, Wordle 1,922 6/6? ⬜⬜⬜⬜⬜ ⬜🟨⬜⬜⬜ 🟨🟩⬜⬜⬜ ⬜🟩⬜⬜🟩 ⬜🟩🟩🟩🟩 🟩🟩🟩🟩🟩
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Colin Carlson @colincarlson.bsky.social · 23/09/2026
What's behind this tidal wave of epidemics? In the largest study ever conducted on emerging infectious diseases, we show that the popular explanation - "our relationship with nature is out of balance" - doesn't hold up. Out now in Nature, after half a decade of work: www.nature.com/articles/s41...
nature.com
The anthropogenic fingerprint on emerging infectious diseases - Nature
Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data ...
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 23/09/2026
And here we are in a smart little hotel in Middelburg again - but this one in the Eastern Cape. All set for an artisanal G+T before supper!
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 23/09/2026
Breakfast in Bloemfontein! Or in a Wimpy off the N1 highway near Bloem, and we had to drive 100 km this morning to get here - and now 1000 km from home! Two sleeps!! Looking forward to seeing the 🐕 🐕
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 22/09/2026
This is the shamefull leacy of IZrael and its fascist, racist leaders - and the SS-IDF. For a nation that holds up the inhumanity of the Nazis, I say look in the mirror: the SS is looking back.
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Ed Rybicki 🇿🇲🇿🇦🇬🇧🍷🚀 @edrybicki.bsky.social · 22/09/2026
Excellent…!
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