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A One Health perspective on mobile genetic elements and associated antibiotic resistance genes in non-human A. baumannii | Applied and Environmental Microbiology
Antimicrobial resistance (AMR) is one of the major global public health threats. In recent decades, Acinetobacter baumannii has become one of the most significant multidrug-resistant (MDR) bacteria in hospital settings (1, 2). Since 2017, the World Health Organization has classified carbapenem-resistant A. baumannii as a critical-priority pathogen, a status that remains in the most recent update in 2024, which reflects the urgent need for new antibiotics against this bacterium (3, 4). A. baumannii is a frequent cause of nosocomial infections, primarily affecting patients in intensive care units (ICUs), immunocompromised individuals, patients using medical devices (such as catheters), and those with underlying diseases (5).