Overview: The mechanisms that control the balance between self-renewing and differentiating hematopoietic stem cell (HSC) divisions are one major interest of...

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The global trend toward an increasing aged population demographic raises significant societal challenges, particularly concerning health. As organisms age, progressive tissue dysfunction increases the...

Cyclin D1 accumulation enables a switch in melanoma cells from drug-induced quiescence to proliferation.

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Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However...

Transcription factor (TF) dosage is a critical determinant of cellular identity. However, the quantitative relationship between TF dosage and its regulation of chromatin accessibility and gene express...

The biological mechanisms that sustain the vast blood production required for healthy life remain incompletely understood. To search for novel regulators of hematopoiesis, we performed genome-wide in ...

The RNA-binding protein hangover is essential for several stress responses in Drosophila melanogaster. Here, we discover a novel function of hangover in the regulation of gene expression. Hangover bin...

New CAR-T Cell Therapy Shows Promise for Hard-to-Treat Cancers