Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...

In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

Summary: Cx41.8 is necessary to launch the haemogenic program and induce HSPC formation at the correct time during zebrafish development via a ROS-Hif-Notch-Gata2b pathway.

Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

This study reveals that cells of the zebrafish kidney can originate from the somites, structures traditionally held as precursors to the skeletal muscle, challenging a century-old paradigm and prompti...

Here, I run though three examples of evolutionary novelty driven by single non-coding DNA changes: limb loss in snakes, gliding in sugar gliders, and coat coloration in African striped mice. These …

Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...

Biological sciences; Zoology; Evolutionary biology

Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental ...

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

YouTube video by The Company of Biologists

Summary: A continuous fluorescent labelling strategy for long-term cell tracing, enabling effective visualisation of endodermal cells and their development from embryos to adults.

As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...

RIKEN researchers have shown that that hydrostatic pressure is one of two mechanisms that control endothelial cell migration during angiogenic sprouting in zebrafish

Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formati...