Sign in

Stefan Mundlos

@stemundi.bsky.social
182 followers 27 following 18 posts
PostsRepliesMedia
Reposted by Stefan Mundlos
Juliane Glaser @julianeg.bsky.social · 24/07/2025
So happy to see the illustration of our work featured on the cover of @natgenet.nature.com 😍 It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!
0344
Reposted by Stefan Mundlos
Ariadna Morales @ariadnamorales.bsky.social · 23/07/2025
So happy to see this paper out in @natecoevo.nature.com. Huge congrats to the whole team, and especially to @fany-real.bsky.social, @dariloops.bsky.social, @stemundi.bsky.social, Magdalena Schindler & Christian Feregrino. Ever wondered how bats develop wings from their hands? 🦇 Enjoy the read ;) 👇
062
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
Our comparative single-cell study on limb development in bats vs. mice reveals insights how evolution can produce massive changes by just changing the expression of a few TFs 😱 www.nature.com/articles/s41...
011
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
Our really exciting bat work got published. This was a fantastic effort by @fany-real.bsky.social, @dariloops.bsky.social, Magdalena Schindler and Christian Feregrino. Many thanks to all our collaborators! who made this possible!!! www.nature.com/articles/s41...
nature.com
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
030
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
Our first paper in Naturre Ecology & Evolution - it won't be the last. Essential insights in bat wing development and how evolution achieves such drastic morphological changes: www.nature.com/articles/s41...
nature.com
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
000
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
Our first bat story is out! What turns a limb into a wing? Evolution's most impressive adaptation. The massive difference is achieved by small changes and the re-purposing of existing pathways - the principle of parsimony! Meis2 gene, normally expressed in proximal limb gets expressed distally.
021
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
50-70% of cases for WGS remain undiagnosed. Searching for an explanation? Read this article by Glaser et al. Activation of endogenous retroviruses can induce cell death in the embry. You can detect virus-like particles in these cell in EM! www.nature.com/ng/volumes/5...
nature.com
Nature Genetics - An endogenous retrovirus causes limb malformation
Activation of a long terminal repeat retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles that cause limb malformation in...
000
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
Our new story in Nature Genetics: endogenous retroviruses can produce viral-like particles in the embryo resulting in apoptosis and congenital malformation. If this would happen in human, it wouldn't leave a trace. No WGS or other analysis would identify this. www.nature.com/articles/s41...
nature.com
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
0288
Stefan Mundlos @stemundi.bsky.social · 24/07/2025
Nature Genetics' new issue is out: Our project is on the cover: An endogenous retrovirus causes limb malformation. Juliane's great scientific work and Anna's cover design!
040
Reposted by Stefan Mundlos
Anna A Monaco @annaamonaco.bsky.social · 23/07/2025
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually. www.nature.com/ng/volumes/5...
The cover of Nature Genetics July 2025 issue. Digital art of a mouse paw skeletal prep on dark background, digits I to IV disintegrating into viral particles. A caption says “An endogenous retrovirus causes limb malformation”.
48322
Stefan Mundlos @stemundi.bsky.social · 15/05/2025
Genome comparisons identify gene flow events between three species of right whales and the bowhead whale. Evidence of historical trans-equatorial migration during ancient glacial cycles. Beautiful work by BaiWei Lo in the lab together with Paolo Franchini: Genome Biology and Evolution, in press.
040
Reposted by Stefan Mundlos
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 14/05/2025
Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42... Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran... @irbbarcelona.org @xsalvatella1.bsky.social
153
Stefan Mundlos @stemundi.bsky.social · 13/05/2025
A genetic study on Korean divers renowned for their remarkable diving abilities. They identified SNPs, one associated significantly with RBC count. Hematological variation is believed to provide additional oxygen capacity during diving. COOL! www.cell.com/cell-reports...
cell.com
Genetic and training adaptations in the Haenyeo divers of Jeju, Korea
Aguilar-Gómez et al. find evidence of evolutionary adaptation with potential relevance to breath-hold diving in the Haenyeo divers of Korea. Genetic variants under selection in this population may hel...
000
Reposted by Stefan Mundlos
Mike Robson @drmrobson.bsky.social · 08/05/2025
The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.
0297
Stefan Mundlos @stemundi.bsky.social · 09/05/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...
081
Reposted by Stefan Mundlos
Konrad Chudzik @konrad-chudzik.bsky.social · 08/05/2025
Thanks also to the @stemundi.bsky.social lab where this work started and the Robson lab where it was finished! Last, my amazing supervisor @drmrobson.bsky.social who devised the inducible DamID mouse and spearheaded the project!
121
Stefan Mundlos @stemundi.bsky.social · 09/05/2025
Fantastic work - groundbreaking, important!
020
Stefan Mundlos @stemundi.bsky.social · 09/05/2025
This is an important paper: genome-lamina interactions are selectively released in early multipotent progenitors preceding gene expression, suggesting it primes regulatory domains for future potential activation. Fantastic collboration of Robson/Kind/Mundlos labs.
0142
Stefan Mundlos @stemundi.bsky.social · 09/05/2025
Our new study on whale genomics by BaiWei Lo together with Paolo Franchini. Evidence of historical trans-equatorial migration impacted by glacial cycles and connectivity of bowhead whale populations between the North Pacific right whale, the Southern right whale and the North Atlantic right whale.
020
Reposted by Stefan Mundlos
Juliane Glaser @julianeg.bsky.social · 07/05/2025
Beautiful work 🤩
032
Reposted by Stefan Mundlos
Iana V. Kim @ianakim.bsky.social · 07/05/2025
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
nature.com
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
13269115
Reposted by Stefan Mundlos
Rada-Iglesias Lab @radaiglesiaslab.bsky.social · 03/05/2025
Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.
063
Reposted by Stefan Mundlos
Alfonso Martinez Arias @amartinezarias.bsky.social · 04/05/2025
Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn
37114
Stefan Mundlos @stemundi.bsky.social · 07/05/2025
Cassandra Extavour today at MPIMG.
010
Stefan Mundlos @stemundi.bsky.social · 06/05/2025
Nature is amazing! Efficient waste disposal as documented by my nest camera. Its all in the DNA, or?
020
Stefan Mundlos @stemundi.bsky.social · 06/05/2025
Our BAT paper is accepted in Nature Ecology & Evolution! Single cell, gene regulation, TADs and key TFs that shape the bat wing. Genomics goes Evodevo 😍
16416