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M. Brent Hawkins

@homeobox.bsky.social
457 followers 388 following 97 posts

Developmental genetics and evolution of the vertebrate skeleton. Postdoc in the Harris Lab at Boston Children's Hospital/Harvard Medical School. Every day is fin day. He/him/his.

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Reposted by M. Brent Hawkins
Meng Zhu @zhumeng123.bsky.social · 24/09/2026
Two years since the 1st submission, our work on limb heterochrony is finally out! 🎉🎊 @cellcellpress.bsky.social Delayed hindlimb dev vs forelimb is a widely conserved trait in mammals. We show that maternal O2 regulates this phenotype 👉🏻 shorturl.at/MGrwl
shorturl.at
Shifts in embryonic oxygen levels cue heterochrony in limb initiation
Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus cont...
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Molly Edwards, PhD @science-irl.bsky.social · 14/09/2026
I had so much fun geeking out about plants and Nausicaä with @stevenraymorris.bsky.social !!
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Marco Podobnik @mpodobnik.bsky.social · 10/09/2026
Our @natrevgenet.nature.com article out now. This is a hymn to danionin fishes, with sections on phylogeny, reproduction, immunity, morphology, regeneration and behaviour. rdcu.be/CntbxvfZsUba
rdcu.be
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Rita Mateus @ritamateus.bsky.social · 03/09/2026
We have a brand new lab website! Lot's of useful bits about our science and team. Check it out at www.ritamateus.com/home/
ritamateus.com
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School of Integrative Biology at Illinois (SIB) @ibioillinois.bsky.social · 03/08/2026
And we're excited to have you joining us at Illinois!
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M. Brent Hawkins @homeobox.bsky.social · 31/07/2026
"After you open a new bottle be sure to mark it with the date"
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M. Brent Hawkins @homeobox.bsky.social · 23/07/2026
Thank you all so much for your support! The Department of Evolution, Ecology, and Behavior is a fantastic group especially if you are ichthyologically minded. And there is @prairieresearch.bsky.social as well! Looking forward to doing science with great colleagues 🐟 sib.illinois.edu/departments/...
sib.illinois.edu
Evolution, Ecology, and Behavior | School of Integrative Biology | Illinois
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Milton Tan @mtanichthys.bsky.social · 23/07/2026
Fish evolution at UIUC gets even stronger! 💪
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Zebrafish Rock! @zebrafishrock.bsky.social · 23/07/2026
New lab incoming ⌛️
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Ale Mongera @mongeralab.bsky.social · 23/07/2026
This is going to be awesome!
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Xtremo-Devo Lab @ WMU @xtremo-devo-lab.bsky.social · 23/07/2026
Excited to see what’s next!
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闵娅(Min Ya; Minya) PhD @minyaaa.bsky.social · 23/07/2026
Omg you FINALLY announced!!! So excited to have you here!!! 🥳🥳🥳 Also Brent and I are gonna team teach upper level Evo-Devo together. Yep you hear that right: we are doing both plants and animals! It’s gonna be 🔥🔥🔥
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Ceri Weber @ceriweber.bsky.social · 23/07/2026
At #2018SDB in Boston, @homeobox.bsky.social, @zhumeng123.bsky.social, and I were grad students scheduled to give talks at the same time, so we grabbed lunch instead to swap work and future plans. Eight years later, all three of us are opening labs! @socdevbio.bsky.social
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M. Brent Hawkins @homeobox.bsky.social · 23/07/2026
I am excited to open my lab at @ibioillinois.bsky.social in Spring 2027! We will use zebrafish & other fishy friends to reveal the genetic basis of large scale changes in the vertebrate body plan, and how this impacts both human health and evolution. Join me at UIUC! 🧬🧫🔬 www.hawkinslaboratory.com
A confocal image of a zebrafish embryo featured on the webpage for the Hawkins Lab at UIUC
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Ceri Weber @ceriweber.bsky.social · 08/07/2026
I am so excited to announce that the Weber Lab will be opening in the Department of Anatomy, Physiology, & Cell Biology @ucdavisvetmed.bsky.social @ucdavis.bsky.social. We will be investigating the development and evolution of vertebra size, shape, and function. And yes, the jerboas are coming with!
Weber Lab logo featuring silhouettes of a jerboa and a mouse in motionCeri looking happy in her new lab space!Lesser Egyptian jerboa from https://www.science.org/content/article/how-jerboa-got-its-enormous-feet
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Neil Shubin @neilshubin.bsky.social · 25/06/2026
My editorial in this week’s Science @aaas.org www.science.org/doi/10.1126/... 🧪
science.org
The enduring pursuit of science in America
Imagine an American organization that convenes scientific experts not to advance any ideology or interest but to provide the nation with a clear understanding of complex problems. Imagine this body wo...
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M. Brent Hawkins @homeobox.bsky.social · 22/06/2026
Excited to share the final published version of our work on the evolution of dorsal-ventral patterning in fins and limbs, now up on @currentbiology.bsky.social In review we added new single LARM element deletions to assess their impact on dorsality. Take a look! 🔬🧪🐟🐁 www.cell.com/current-biol...
A scientific figure showing the phenotypic effects of removing individual enhancer elements from the LARM. On the left side of the image are schematic diagrams of the targeted deletions and on the right are fin skeletons showing altered anatomy.
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J Pardo @jdpardo.bsky.social · 18/06/2026
New in @science.org ...since our first discoveries of early tetrapods, they have been thought of as "amphibians" characterized by aquatic larvae. But is this true? For the first time, we report exceptional fossils of stem tetrapod babies that upend this paradigm. 1/n www.science.org/doi/10.1126/...
science.org
Direct development of stem tetrapods across the fin-to-limb transition
Modern amphibians are characterized by an aquatic larval stage that ends abruptly with a period of widespread tissue remodeling (metamorphosis) upon transition to terrestrial adulthood. A transient la...
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Sarah McMenamin @mcmenaminlab.bsky.social · 21/05/2026
New preprint! We found that distinct positional identity patterns the central features of the zebrafish caudal fin. But, to quote WB Yeats, "The centre cannot hold:" when central identity is disrupted, the center "collapses" and the fin develops with a novel shape. www.biorxiv.org/content/10.6...
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M. Brent Hawkins @homeobox.bsky.social · 15/05/2026
Nice try Min Ya but this is clearly The Incredible Mr. Limpet
A still from the movie The Incredible Mr. Limpet showing an anthropomorphized fish
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Tschopp Lab @tschopplab.bsky.social · 14/05/2026
One of my dream projects, ever since joining here in Basel, out now in @nature.com : single-cells 🤝 eco-morphological proxies rdcu.be/fiyso How cells and tissues adapt to dietary niches... Thanks and congrats to Antoine, Walter, and all the other co-authors for this great collaboration!! 🙏🥳
rdcu.be
Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Nature - Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary...
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Ali Seleit @aliseleit.bsky.social · 05/05/2026
(1/15) Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
biorxiv.org
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Marco Podobnik @mpodobnik.bsky.social · 25/02/2026
Beautiful work led by Yansong (Kevin) Lu on skeletal muscle growth in zebrafish, giant danio, Danionella cerebrum, and killifish. HCR, new image analysis tool, scRNA-seq, and CRISPR. New international collaborations between Uni Melbourne, NCVC/Osaka, Stanford & ARMI www.biorxiv.org/content/10.6...
New morphometric analysis tool developed by Lu et al. applied to skeletal muscle cross-sections of four different juvenile teleost fish species. Main finding: Mosaic hyperplasia, i.e., the addition of new myofibers in the deep myotome, is near-zero in the small Danionella but dramatically enhanced in the giant danio relative to the intermediate grower zebrafish, establishing this mode of hyperplasia as a main driver of skeletal muscle growth in differently sized fishes.
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M. Brent Hawkins @homeobox.bsky.social · 22/04/2026
Lost noodle or zebrafish embryo?
A photograph of a noodle juxtaposed with an illustration of a zebrafish embryo
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Champi @jpascualanaya.bsky.social · 16/04/2026
🔈 Heading to Euro Evo-Devo #EED2026 in Glasgow? Don't miss out our Fish Satellite Meeting! Co-organized with Mike Dorrity @mwdorr.bsky.social, Ralf Schneider @ralfschneider.bsky.social, Laure Sanders @lsaunders.bsky.social and Joost Woltering, and with a list of outstanding speakers 👇
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Denis Duboule @denisduboule.bsky.social · 16/04/2026
This year, the annual symposium of my Chaire @college-de-france.fr will be on The Evolution of Developmental Mechanisms. An impressive lineup of speakers and weirds animals, including humans. Free entrance and coffee breaks. Come, have a seat, relax and enjoy the best possible basic science🤘RT🙏
Pictures from Fanny Martinez Real and Stefan Mundlos🙏
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Meng Zhu @zhumeng123.bsky.social · 13/04/2026
This Thursday! 🐓🐁
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James Gagnon @james-gagnon.bsky.social · 13/04/2026
In 1936, a U.S. Forest Service ranger was fishing high in the Utah mountains when he found something bizarre: Cutthroat trout with tiny - or missing - dorsal fins! 🧵
A black and white photo of two trout missing their dorsal fins, taken in 1936.
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Parichy Lab | Dave Parichy @dparichy.bsky.social · 03/04/2026
Zebrafish finds Nemo. New paper with our great collaborators on gap junctional communication in widely divergent species. www.nature.com/articles/s41...
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Kazuhide Miyamoto @miyamoto-evodevo.bsky.social · 27/03/2026
Happy to share the version of record, published in Nature communications yesterday!
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feña Palominos @fishfena.bsky.social · 20/03/2026
Big news from @evodevopanam.bsky.social 🤩 ⭐️EvoDevo Mondays⭐️ This session will be chaired by the one and only Natalia Pabon Mora from the Universidad de Antioquía, Colombia. And as speakers, @luiza-o-saad.bsky.social and Joao Botelho (both originally from 🇧🇷) Stay tuned for the link!
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Ben Ewen-Campen @benforward3.bsky.social · 05/03/2026
🪰If you’re at #Dros26 and are interested in the fly foregut AND/OR want to support scientists in elected office, please come to talk Friday at 9:45am AND/OR support my run for State Representative in MA :) www.benforward3.com/blog/2026/3/...
The proventriculus lacks stem cells, but compensates for
age-related cell loss via
endoreplication
Ben Ewen-Campen
Perrimon Lab, Harvard Medical School
Fly Meeting 2026I'M RUNNING
FOR
STATE REP!
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feña Palominos @fishfena.bsky.social · 04/03/2026
Join us this next Friday *the 13th* 👻 👻 to hear us talking about bones and cartilages in development and evolution 🐟 🐠 🦴
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Department of Biology | San Francisco State University @sfstatebio.bsky.social · 03/03/2026
🐟👀 SFSU Biology seminar — Thu Mar 5 2–3pm | SEC 116 Dr. Patricia Schneider (LSU): “Split Screens: Exploring Vision through the Eyes of the Four-Eyed Fish.” Student time: 3–3:30pm. Come by!
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Arnaud Martin @evolvwing.bsky.social · 25/02/2026
Super excited about these results and new system. Mapping, Expression, Loss-of-Function I'm floored by how this locus seem to integrate all the spatial info to sketch the minute details of the phenotype, and how this is prone to evol tweaks Large hyperdiverged haplotype without an inversion.
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National Academy of Sciences @nasonline.org · 04/02/2026
Neil H. Shubin has been elected as the next NAS President! A leading evolutionary biologist and science communicator, Shubin will succeed Marcia McNutt on July 1. The Academy also named Cherry Murray as International Secretary and elected new councilors. Read more: www.nasonline.org/news/2026_pr...
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M. Brent Hawkins @homeobox.bsky.social · 23/01/2026
🧪🔬🧬Beautiful work! Many people have long wondered what the impact of actinodin loss would be on fin development. www.biorxiv.org/content/10.6...
biorxiv.org
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Gabriela Lima @gabrielalima19.bsky.social · 22/01/2026
It’s out! 🐟 We compared three regeneration superstars—axolotl, zebrafish, and Polypterus—to ask how animals regrow limbs and fins. We find shared core processes, and other programs fine-tuned by evolution in surprising, lineage-specific ways. tinyurl.com/mpftkn7y
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Molly Edwards, PhD @science-irl.bsky.social · 21/01/2026
@pbs.org has had my whole heart since I was little little, so it is very surreal to be writing for a PBS Digital Studios show! Here is my first episode of Be Smart: www.youtube.com/watch?v=4SBX... Thank you @drjoehanson.bsky.social & team! My nose knowledge now knows no bounds 👃
youtube.com
Everything I Thought I Knew About Flavor Was Wrong
YouTube video by Be Smart
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闵娅(Min Ya; Minya) PhD @minyaaa.bsky.social · 24/11/2025
Very happy to share that this paper is now online on @currentbiology.bsky.social !! 🥳🧪 Check out the final published verion here: www.cell.com/current-biol... #mimuluspropaganda
cell.com
Spatiotemporal dynamics of CYCLOIDEA expression during early floral development in monkeyflower
Bilateral floral symmetry is a repeated evolutionary innovation governed by the CYCLOIDEA-dependent program, yet how the dorsal-specific CYC expression is initiated and maintained remains elusive. Min...
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Arnaud Martin @evolvwing.bsky.social · 16/11/2025
🚨New paper! 🚨 @jasminealqassar.bsky.social led this work on the silk glands of the pantry moth. These two long tubes inside the caterpillar continuously make a ton of silk How does this special organ work? www.cell.com/iscience/ful... @cp-iscience.bsky.social 🧵THREAD🧵
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M. Brent Hawkins @homeobox.bsky.social · 15/11/2025
Toto, I have a feeling we aren't in Actinopterygii anymore
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Arnaud Martin @evolvwing.bsky.social · 12/11/2025
It's out, Minos transgenesis in the pantry moth by @donyaniyaz.bsky.social @lucalivraghi.bsky.social High efficient, glowing eye and silk gland markers peerj.com/articles/202... @peerj.bsky.social
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Denis Duboule @denisduboule.bsky.social · 07/11/2025
The talks (in english) can be accessed from the @college-de-france.fr website. A great journey through ‘Our ancestors the fish’, from 380 Mio years ago to their hidden presence inside ourselves. Lessons #1 and #2 👇🏼 www.college-de-france.fr/en/agenda/gu... www.college-de-france.fr/en/agenda/gu...
college-de-france.fr
Neil Shubin (1) | Collège de France
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Aaron Griffing @aaronhgriffing.bsky.social · 05/11/2025
Pretty stoked that our article got the cover of the latest issue of @journalofanatomy.bsky.social! Check it out here: doi.org/10.1111/joa....
The December 2025 cover of Journal of Anatomy, depicting a CT scan skeleton of Aristelliger georgeensis with hemipenes featuring mineralized hemibacula
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M. Brent Hawkins @homeobox.bsky.social · 04/11/2025
Extremely cool to see very different systems potentially point to similar genetic constraints or developmental biases leading to morphological variation. Now we need a fish example!
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Patricia Schneider @patyschneider22.bsky.social · 04/11/2025
How do four-eyed fish see above & underwater? 🌤️🌊 Our new preprint reveals how Anableps rewired its retina for dual vision- evolution at work 👁️👁️ Kudos to @perezlouise.bsky.social @josanesousa.bsky.social @keylapruett.bsky.social + team! 🔗 tinyurl.com/3a8r9xy5
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Marco Podobnik @mpodobnik.bsky.social · 20/10/2025
Happy to have contributed to this big story. We present new genome assemblies, genus-wide complementation and allele-specific expression analyses in hybrids between zebrafish and closely related Danio species with divergent pigment patterns. A vertebrate model genus for basic comparative biology.
Genus-wide one-way complementation assays in hybrids between zebrafish and closely related Danio species with divergent pigment patterns
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Igor Schneider @ischneider.bsky.social · 14/10/2025
Hey Regen folks 👋 Excited to share that our single-nucleus RNA-seq dataset for Polypterus fin regeneration is now live at the Broad Institute portal! Dive in here: tinyurl.com/5bck22jx Big thanks to the team for making this happen—looking forward to seeing what you all discover!
UMAP of single nucleus RNAseq dataset of Polypterus fin regeneration
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M. Brent Hawkins @homeobox.bsky.social · 14/10/2025
The regulation and evolution of proportion is a classic challenge in biology. This is exciting work into the genetic and developmental basis of proportionality using a very cool model. Congrats Ceri! 👏🧪🧬🐭
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