Nature Communications - Ribosome hibernation preserves translation machinery during stress. Here, the authors identify a ribosome hibernation factor that is widespread in archaea and combines...

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

Nature Reviews Genetics, Published online: 27 January 2025; doi:10.1038/s41576-024-00810-1In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and…

DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren...

In their structural analysis of the NSUN6-SFG-mRNA ternary complex, Zhong et al. identified a compound known as thiamine disulfide through NMR and virtual screening. This compound has subsequently bee...

Eukaryotic Arf family proteins involved in endomembrane organelle dynamics arose from the Asgard archaeal ArfR GTPases, indicating this capability likely originated in the archaeal ancestor of eukaryo...

Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

Nature Communications - The single stranded DNA binding protein RPA plays a pivotal role in DNA replication. The archaeal RPA hosts a WH domain that interacts with the DNA primase and the...

DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren....

Abstract. Tau protein plays a central role in Alzheimer’s disease (AD) and other tauopathies. Tau proteins aggregate in degenerating neurons and their expr