The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Tuberculosis is the deadliest bacterial disease on the planet. The months-long regimen of multiple antibiotics required to treat tuberculosis profoundly affects the microbiome and leads to the development of antimicrobial resistance. Furthermore, non-tuberculous mycobacterial infections pose an incr …

The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmenta...

Less research equates to less business between the university and these Worcester companies, spreading the pain far beyond campus borders.

Antibiotics that inhibit ribosomes lead to collisions on mRNAs when upstream ribosomes catch up with stalled ones. Campbell et al. show that the HrpA protein in E. coli senses ribosome collisions and ...

Ribosomes cooperate through transient collisions to ensure efficient translation.

Many new small RNA species and their derived fragments have been recently identified in animals. This Review discusses the biogenesis and functions of both structural small RNAs, such as tRNAs and sma...

During eukaryotic translation initiation, the small (40S) ribosomal subunit is recruited to the 5ʹ cap and subsequently scans the 5ʹ untranslated region (5ʹ UTR) of mRNA in search of the start codon. ...

Summary: The 2024 Nobel Prize in Physiology or Medicine has been awarded for the discovery of miRNAs; the groundwork was laid by investigating the timing of developmental events in nematodes.

Nature Communications - Cells adapt to low glucose by halting protein synthesis and altering organelle shape. Here the authors showed that hibernating ribosomes tether to mitochondria and form...

The ribosome is an ancient molecular machine that coverts the genetic information carried by mRNA into protein, a crucial step in linking genotype to phenotype. This review discusses landmark advances...

The ribosome activates an enzyme that cleaves transfer RNA.

Synthesis of peptidyl-tRNAs is challenging because there ...

Ribosomes that become stalled on truncated or damaged mRN...

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The states through which ribosomes, the molecular machine...