iiinova — where your digital self keeps evolving

Reposted by Leonie Kollenstart

The Groth lab @grothlab.bsky.social · 14/01/2026

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

A picture of current members of the Groth lab

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The Groth lab @grothlab.bsky.social · 07/11/2025

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

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Susi Bantele @sbantele.bsky.social · 06/11/2025

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

tinyurl.com

Repair of DNA double-strand breaks leaves heritable impairment to genome function

Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

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Vijay Ramani @vram142.bsky.social · 20/09/2025

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

biorxiv.org

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

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The Groth lab @grothlab.bsky.social · 28/08/2025

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

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Alessandro Costa @costalaboratory.bsky.social · 20/06/2025

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

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Jeroen van den Berg @jervdberg.bsky.social · 16/05/2025

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists shorturl.at/avBBy

shorturl.at

Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute

About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...

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The Groth lab @grothlab.bsky.social · 20/05/2025

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

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Anja Groth @groth-anja.bsky.social · 28/03/2025

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

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The Groth lab @grothlab.bsky.social · 06/03/2025

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

rdcu.be

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply

Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...

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Leonie Kollenstart @lleonie.bsky.social · 20/02/2025

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

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Leonie Kollenstart @lleonie.bsky.social · 17/02/2025

Moving-in day at the Danish Cancer Institute! Look at this pristine, untouched lab 🤩

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Leonie Kollenstart @lleonie.bsky.social · 12/02/2025

Want to join us in 𝐂𝐨𝐩𝐞𝐧𝐡𝐚𝐠𝐞𝐧, 𝐃𝐞𝐧𝐦𝐚𝐫𝐤? 🇩🇰 Our new 𝐂𝐞𝐧𝐭𝐞𝐫 𝐟𝐨𝐫 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐂𝐞𝐥𝐥 𝐌𝐞𝐦𝐨𝐫𝐲 (𝐄𝐩𝐢𝐂) is hiring 6 PhDs & postdocs! This is an amazing chance to be part of a top-tier research environment in Europe. I can’t recommend these labs enough! 🔬✨📢 Apply here 👇 & spread the word! #Hiring #AcademicJobs

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Leonie Kollenstart @lleonie.bsky.social · 10/02/2025

I'm thrilled that this chapter from my PhD, completed and elevated by @sophievdhorst.bsky.social and other co-authors, is now published in Nature Communications! Check it out 👇.

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The Groth lab @grothlab.bsky.social · 20/12/2024

Exciting news!🌟 Together with Alexander van Oudenaarden, @jervdberg.bsky.social and @lleonie.bsky.social, we’ve been awarded a €2M NNF Synergy grant. We're thrilled to collaborate🤝 and to develop cutting-edge single-cell and single-molecule methods for replication and chromatin research! 🚀

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Hubrecht Institute @hubrechtinstitute.bsky.social · 20/12/2024

How reliably is the epigenome passed from one cell to its daughter cells? Alexander van Oudenaarden @jervdberg.bsky.social @grothlab.bsky.social @lleonie.bsky.social received @novo-nordisk.bsky.social grant to study this question ➡️new strategies to prevent disease & combat aging tinyurl.com/yh925b9u

hubrecht.eu

Van Oudenaarden and Groth research groups receive Novo Nordisk Foundation Synergy Grant for Epigenome Fidelity - Hubrecht Institute

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Leonie Kollenstart @lleonie.bsky.social · 20/12/2024

Yesss! 🎉 We’ve secured a €2M Synergy grant from @novo-nordisk.bsky.social 🤯! What started as fun chats with my amazing friend @jervdberg.bsky.social, turned into an epic collaborative project 🤩. Huge thanks to Alexander and @grothlab.bsky.social for support and guidance. Can’t wait to dive in! 🚀

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The Groth lab @grothlab.bsky.social · 25/11/2024

The Groth lab @grothlab.bsky.social has also made the jump from X to Bluesky🤩! Please follow us for all things related to chromatin replication, epigenetic memory and (epi)genome stability in the context of mitotic cell division! We'll start on joining some relevant starter packs!

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Nilsson lab @nilssonlab.bsky.social · 17/11/2024

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community: candidate.hr-manager.net/ApplicationI...

candidate.hr-manager.net

Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute

Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Do you want to be part of a state-of-the-art core facilit

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