Reposted by Sam MugfordDr. Stephanie @punkrockscience.bsky.social · 12/10/2026Interviewer: Can you explain this gap in your CV? Scientist: That’s the non-coding portion of my CV - we’re not yet sure what all of it does, but we keep discovering new reasons that it’s there. 324144
Reposted by Sam MugfordAnn LeBlanc @robotleblanc.bsky.social · 09/10/2026friday is for kafkaposting 4771671698
Reposted by Sam MugfordDorothy Bishop @deevybee.bsky.social · 10/10/2026it’s confirmation bias all the way down 183
Reposted by Sam MugfordWilliam Gibson @greatdismal.bsky.social · 09/10/2026Having long been aware of those tech bros who read my work as utopian porn, where they’ve taken that doesn’t exactly surprise me. 12073891885
Reposted by Sam Mugfordmatty @mattio.bsky.social · 08/10/2026This is wild - somebody did a deep dive into the real stories behind this famous XKCD: sheets.works/data-viz/hol... 251314628
Reposted by Sam Mugforddepths of wikipedia @depthsofwikipedia.bsky.social · 06/10/2026wikipedia has been ANNIHILATED with AI bot traffic for a while now (because LLMs can't get enough of it) which puts a huge burden on its tech and server costs. and now it looks like bots are making unauthorized edits to pages and trying to hack community tools diff.wikimedia.org/2026/10/05/o... 111000292
Reposted by Sam MugfordPhil M 🦻🏼💚 🍉 🏳️⚧️ 🇵🇸 @phillm.bsky.social · 05/10/2026When they talk about reducing red tape, remember this image. 5428481093
Reposted by Sam MugfordRandall Munroe @xkcd.com · 29/09/2026Jupiter Icy Moons Explorer xkcd.com/3304/ 151965285
Sam Mugford @samtmugford.bsky.social · 29/09/2026Toadfish does sound like a CIA codename for a false flag operation 040
Sam Mugford @samtmugford.bsky.social · 24/09/2026When you die, the first thing you hear is Melvyn saying "and now some extra time for the podcast. What would you have said if you had time?" 000
Reposted by Sam Mugfordchaircrusher @cornwarning.com · 21/09/2026I started working as a programmer in 1984. Throughout my career, we spent a lot of time on making code more efficient, faster running. If nothing else, LLMs are the opposite. Let's make programs that require trillions of dollars of infrastructure, that get things wrong! 101
Reposted by Sam MugfordTom Cox @dj-acid-reflux.bsky.social · 20/09/2026What I want is a TV documentary channel entirely devoted to documentaries with no quick-cut montages of everything about to happen, which don't give a fuck about keeping my attention, presented by extremely knowledgeable people in a terrible mood who have no interest in trying to make me like them 64972160
Reposted by Sam MugfordJitte @jittebug.nl · 19/09/2026I came across on my hard drive while looking for other things. I segmented the nervous system and part of the digestive system in this Atta vollenweideri head, then apparently I animated it and forgot it existed... This was based on CT data graciously provided by the Labonte lab. 32610
Reposted by Sam MugfordKevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026found at ucsf 9558118
Reposted by Sam MugfordSergey Ovchinnikov @sokrypton.org · 14/09/2026Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr) 727698
Sam Mugford @samtmugford.bsky.social · 14/09/2026as dystopian as everything is, I'm glad i live in the "Ilfracombe blade runners" timeline 010
Sam Mugford @samtmugford.bsky.social · 10/09/2026See also our preprint on this story www.biorxiv.org/content/10.6... @qunliu07.bsky.social @saskiahogenhout.bsky.socialbiorxiv.orgThe aphid effector CathB6 suppresses EDS1-dependent immunity and rewires MORF2–GUN1–GLK signalling to sustain host cellular homeostasis in ArabidopsisAphids use stylet mouthparts to probe plant tissues and deliver oral secretions into host cells, modulating immunity to establish long-term phloem feeding sites in sieve elements. This feeding behavio... 000
Sam Mugford @samtmugford.bsky.social · 10/09/2026Come see my poster (number 10) about Aphid cathepsin B effectors and how they influence chloroplast processes #ppath2026 #bspp zenodo.org/records/2070... 110
Reposted by Sam MugfordMagnus Bauer @kinasekid.bsky.social · 06/09/2026AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳 16028
Reposted by Sam MugfordAnna Grzymala-Busse @annagbusse.bsky.social · 02/09/2026He gets a sabbatical?? 2656
Sam Mugford @samtmugford.bsky.social · 01/09/2026static.klipy.comFunny Sausage Fingers IllusionALT: Funny Sausage Fingers Illusion 010
Reposted by Sam MugfordBrian Honan @brianhonan.bsky.social · 29/08/2026Happy Skynet day to all those who celebrate 6252201723
Reposted by Sam MugfordFlight Free UK @flightfreeuk.bsky.social · 29/08/2026Thanks for sharing and tagging us @markannand.eurosky.social a live, real time rail map. What a fantastic view of the European rail network in action. Inspiration for so much sustainable travel and slow travel adventure. 🌎💚 0124
Reposted by Sam MugfordPeter Moffett @moffettpeter.bsky.social · 28/08/2026New preprint from @s-gauthier.bsky.social and @charlesrleveillee.bsky.social in collaboration with the labs of Xuifang Xin, @gittacoaker.bsky.social and Laurent Noël Water immunity: Yesterday's preprint: Dampness is a DAMP... today's: ...but it also dampens defense www.biorxiv.org/content/10.6...biorxiv.orgExtracellular water withdrawal drives disease resistance in the phyllosphereA central question in immunity is how hosts arrest pathogen growth. Diverse plant pathogens create a water-soaked niche in host tissue essential for pathogenesis, yet how water shapes infection outcom... 0249
Reposted by Sam MugfordTits McGee @scientits.bsky.social · 28/08/2026Norfolk being sat on top of an ancient supervolcano explains a lot 2375
Sam Mugford @samtmugford.bsky.social · 26/08/2026I guess we got to start using bonferoni corrections instead of tukey tests? 010
Reposted by Sam MugfordCredentials, Dan @dancredentials.bsky.social · 15/08/2026Me, nodding knowingly: The beaks. 10293091568
Reposted by Sam Mugfordsophiacollins.bsky.social @sophiacollins.bsky.social · 23/08/2026You know why 074
Reposted by Sam MugfordSteve "It's TAY-tro" Tetreault @drtlovesbooks.bsky.social · 20/08/2026This Threads post by @joedator.bsky.social nails it. #AiIsTheProblem #TechLiteracy 317157
Reposted by Sam MugfordPetros Ligoxygakis @petrosligoxygakis.bsky.social · 23/08/2026“The public interest is not the same thing as the public being interested”. Pertinent as always by Will Self on the central role of British media in the death of Dr. Jason Arday. willself1.substack.com/p/2089334077...willself1.substack.comJason Arday: J'Accuse the British MediaAfter the death of Jason Arday, Will Self asks what happens when the media machine mistakes what interests the public for the public interest. 011
Reposted by Sam MugfordGeorge Monbiot @georgemonbiot.bsky.social · 23/08/2026HG Wells is alleged to have remarked "Every time I see an adult on a bicycle, I no longer despair for the future of the human race”. You could see this shocking chart as an index of civilisation. A country which gets this issue so badly wrong is likely to fail in many other ways. 601146440
Reposted by Sam MugfordAnn Edahl @ann-edahl.bsky.social · 22/08/2026Optimist: The cup is half full Pessimist: The cup is half empty Excel: It’s January 2 414325
Reposted by Sam MugfordMax Planck Institute for Plant Breeding Research @mpipz.bsky.social · 18/08/2026🔬Big news🥳 We’re excited to welcome Prof. Dr. Rosa Lozano-Durán as new Director and head of the Department of Plant Virology @mpipz.bsky.social Her research focuses on how plant viruses interact with their hosts. 🎉Welcome to MPIPZ, Rosa 🌿🌱 www.mpipz.mpg.de/5842514/loza...mpipz.mpg.deThe Max Planck Institute for Plant Breeding Research welcomes Prof. Dr. Rosa Lozano-Durán as new director 620868
Reposted by Sam MugfordLuca @lucagalletti.bsky.social · 17/08/2026One of French puppeteer Raphaël Gromy’s most recognizable performances features a puppet painting real artworks on canvas, blending puppetry, live performance, and visual art into a unique theatrical experience. 😊 IG: @artistsuniversum @raphael_gromy 338139983424
Reposted by Sam MugfordJohn Innes Centre @johninnescentre.bsky.social · 17/08/2026VACANCY - Funded by @European Research Council (ERC), we have three exciting opportunities for Postdoctoral Researchers to join the newly appointed Dr @hassansalem.bsky.social Group. These roles span: Developmental biology - okt.to/nq50wC 🧵 12441
Reposted by Sam MugfordKetan Joshi @ketanjoshi.co · 14/08/2026This is the coverage of Arday **just in the Telegraph** in the UK. This is only the first four pages of results, just in one outlet. 17455932065
Sam Mugford @samtmugford.bsky.social · 12/08/2026Kudos to @qunliu07.bsky.social , Jianhua Huang, Anna Neefjes, and @saskiahogenhout.bsky.social @johninnescentre.bsky.social 010
Sam Mugford @samtmugford.bsky.social · 12/08/2026Together these data show how an aphid effector introduced into host plants during feeding may suppress immunity whilst simultaneously promoting plant photosynthetic productivity to maximise aphid performance. 8/8 110
Sam Mugford @samtmugford.bsky.social · 12/08/2026We found significant overlap of the CathB6-regulated transcriptome with MORF2- and GLK-regulated transcriptomes, consistent with CathB6 affecting plant processes via these pathways. 7/n 100
Sam Mugford @samtmugford.bsky.social · 12/08/2026We found that both MORF2 and GLKs influence aphid performance on plants. 6/n 100
Sam Mugford @samtmugford.bsky.social · 12/08/2026CathB6 re-localises away from processing-bodies and into the nucleus in the presence of over-expressed GLKs. 5/n 110
Sam Mugford @samtmugford.bsky.social · 12/08/2026We explored the CathB6-interactome, and identified MORF2 plastid RNA-editing factor and GLK transcription factors, both with key roles in regulating chloroplast-nucleus signalling and regulation of photosynthetic gene-expression. 4/n 110
Sam Mugford @samtmugford.bsky.social · 12/08/2026Here we show significant overlap of CathB6- and EDS1-regulated transcriptome in Arabidopsis plants, but also find there is a substantial additional CathB6-regulated processes. 3/n 100
Sam Mugford @samtmugford.bsky.social · 12/08/2026We previously showed that cathepsin B (inc. CathB6) proteins secreted in aphid oral secretions re-localise the plant EDS1 immune signalling protein to processing-bodies to promote aphid performance. www.science.org/doi/10.1126/... 2/nscience.orgAphid effectors suppress plant immunity via recruiting defense proteins to processing bodiesAphids hijack plant immunity via p-bodies, but plants fight back with a heat shock protein in an unexpected twist on defense. 100
![4-panel comic. (1) April 2023: [JUICE space probe flying away from Earth] FROM EARTH: *JUICE* is en route to explore the icy moons of Jupiter! JUICE: *Wheee!* (2) August 2024: [JUICE flying past Earth] JUICE: ...So which planet was I visiting again? I got distracted. FROM EARTH: Jupiter! JUICE: Right, OK. (3) September 2026: [JUICE flies past Earth again] JUICE: Is Jupiter the one with all the rings? Or... FROM EARTH: No, the big one near it. JUICE: Got it! (4) January 2029: [JUICE returning to fly past Earth again] JUICE: And *which* moons am I looking at? FROM EARTH: Oh my *god*. FROM EARTH: Now I get why we budgeted for so many Earth flybys.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreih2hocndvj6rupk5itttpmxce7tdl465uzaf5iibkzipzyvoy4tuq)
