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Salva Iborra

@salva-iborra.bsky.social
748 followers 1.5K following 53 posts

Immunologist obsessed with Dendritic Cells. Scientific Director at Fundación @inmunotek Former PI and professor @ucm.es Former Postdoc @sancholab.bsky.social scholar.google.es/citations?hl=es&u…

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Reposted by Salva Iborra
Allergy EAACI @allergy-eaaci.bsky.social · 16/09/2026
Respiratory inflammation spans a spectrum of upper and lower airway diseases, asthma, chronic rhinosinusitis, allergic and non-allergic rhinitis, and COPD, unified by overlapping type 2 and non-type 2 inflammatory mechanisms.
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Reposted by Salva Iborra
Vienna Airway Lab @viennaairwaylab.bsky.social · 10/09/2026
Type 2 immunity evolved to defend against parasites and support tissue repair, but it also drives allergies/eosinophilic diseases. This review explores the dual role of Type2 immunity in health and disease. #Immunology #CRS #Allergy #Type2Immunity #Biologics 🔗 ino.to/V0T96Ke
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Type 2 Immunity & Allergy Lab @jimenez-saiz-lab.bsky.social · 04/03/2026
La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...
okdiario.com
Alergia al cacahuete: la ciencia mira a la boca para frenar la enfermedad
La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá
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Type 2 Immunity & Allergy Lab @jimenez-saiz-lab.bsky.social · 04/03/2026
Muy agradecidos a El Mundo por divulgar nuestro trabajo en @cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia. www.elmundo.es/ciencia-y-sa...
elmundo.es
Una bacteria de la saliva 'protege' de la alergia al cacahuete, destruyendo en la boca las proteínas dañinas
Dos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las...
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David Sancho @sancholab.bsky.social · 14/02/2026
Excessive #inflammation? We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful... #immunosky
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Salva Iborra @salva-iborra.bsky.social · 26/02/2026
🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.
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Waggoner Lab @labwaggoner.bsky.social · 20/01/2026
Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke www.researchsquare.com/article/rs-8...
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The French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social · 13/01/2026
@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection rupress.org/jem/article/...
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026
My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵
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Salva Iborra @salva-iborra.bsky.social · 30/12/2025
On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇
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Pedro Papotto @ph-papotto.bsky.social · 19/12/2025
Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv: www.biorxiv.org/content/10.6...
biorxiv.org
BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells
γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...
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Journal of Experimental Medicine @jem.org · 05/12/2025
Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/... (1/2) 🧵 👇
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Mucosal Immunology @mucosalimmunol.bsky.social · 05/12/2025
Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...
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Waggoner Lab @labwaggoner.bsky.social · 05/12/2025
mRNA vaccines 💉don't cause death but prevent it Massive study from France showed that mRNA vaccines reduced deaths and saved lives @mahmoudzureik.bsky.social @jama.com jamanetwork.com/journals/jam...
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Salva Iborra @salva-iborra.bsky.social · 05/12/2025
Fascinating study revealing how NK cells can eliminate intracellular E. coli infecting the urothelium. -Just a comment on the NK depletion experiment, NK1.1 is also expressed by ILC1s, NKT and most γδ T1 cells (IFN-γ producers).
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Salva Iborra @salva-iborra.bsky.social · 27/11/2025
👇No os lo perdáis! Hoy, a las 19:00 h, Oscar Palomares hablará en Allergotrends (Inmunotek) sobre los"Avances en inmunidad innata entrenada en inmunoterapia específica de alérgeno: Vacunas bacterianas para la prevención y tratamiento del asma alérgica". eventos.quodem.com/allergotrend...
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Salva Iborra @salva-iborra.bsky.social · 26/11/2025
Gracias @larazonlr.bsky.social ! Por hacerse eco de nuestra investigación. www.larazon.es/salud/que-ma...
larazon.es
¿Por qué es más difícil reinfectarnos de un virus que ya hemos tenido?
Científicos españoles descubren cómo refuerza el sistema inmunitario la defensa del organismo frente a patógenos como la gripe
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Payal Yokota @payalyokota.bsky.social · 19/11/2025
..cross your 't's folks.. here's how! www.nature.com/articles/s41...
nature.com
Guidelines for T cell nomenclature - Nature Reviews Immunology
This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...
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Caetano Reis e Sousa @reisesousalab.bsky.social · 13/11/2025
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
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Rockefeller University Press @rupress.org · 25/11/2025
In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/... #MucosalImmunology
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Waggoner Lab @labwaggoner.bsky.social · 25/11/2025
pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection @jem.org rupress.org/jem/article-...
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Salva Iborra @salva-iborra.bsky.social · 25/11/2025
Excited to share our new paper in @jem.org! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno 🧵👇1/6
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Waggoner Lab @labwaggoner.bsky.social · 30/08/2025
@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses www.biorxiv.org/content/10.1...
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elDiario.es @eldiario.es · 24/08/2025
Aemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registros
eldiario.es
Aemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registros
La Agencia de Meteorología española advierte de que los datos registrados y las previsiones hasta el día 31 de este mes hacen prever que este será uno de los veranos más calurosos de la historia. "¿Y ...
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Angélica Cuapio @dracuapio.bsky.social · 06/07/2025
Our latest review: Inborn errors of immunity affecting the MHC class I pathway for antigen presentation url: rupress.org/jhi/article/...
rupress.org
Inborn errors of immunity affecting the MHC class I pathway for antigen presentation | Journal of Human Immunity | Rockefeller University Press
The paper discusses rare inborn errors of immunity affecting MHC class I antigen processing, leading to infections and skin lesions, often misdiagnosed as
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Salva Iborra @salva-iborra.bsky.social · 30/07/2025
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European Research Council (ERC) @erc.europa.eu · 17/07/2025
🧬 A new study by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) links the gut-derived metabolite imidazole propionate (ImP) to #atherosclerosis. The research explores ImP as a potential marker & contributor to early disease development. 👉 europa.eu/!wBktrm
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The LeibundGut-lab @lableibundgut.bsky.social · 03/06/2025
Are you interested in antifungal immunity in the skin? Then, this postdoc position may be of interest to you 👇 #Immunology #immunosky
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Discovery Immunology @discovimmunol.bsky.social · 04/06/2025
Wild mice reveal surprising immune system differences! 🐭🔬 Discover how wild mouse bone marrow composition contrasts with lab mice, unlocking new immunology insights. Read here: bit.ly/4jtlZeC #Immunology #InnateImmunity
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Yannick Alexandre @yannick-alexandre.bsky.social · 05/06/2025
I’m pleased to share my latest work, published in Science Advances. In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections. #immunology #immunosky www.science.org/doi/10.1126/...
science.org
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.
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Prof Sheena Cruickshank @sheencr.bsky.social · 05/06/2025
As the USA shuts down programs to develop HIV vaccines, we have exiting news from Australia of new work delivering RNA encoding bits of HIV to T cells #Immunosky 🧪🧵
theguardian.com
Breakthrough in search for HIV cure leaves researchers ‘overwhelmed’
Exclusive: Melbourne team demonstrates way to make the virus visible within white blood cells, paving the way to fully clear it from the body
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Prof Sheena Cruickshank @sheencr.bsky.social · 03/06/2025
More evidence of the link between microbiome and immune function as excess antibiotics impair response to vaccines in infants and those with Bifodibacterium in the gut did better with vaccine responses🧪
nature.com
Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology
A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...
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Prof Sheena Cruickshank @sheencr.bsky.social · 04/06/2025
Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪
nature.com
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature Immunology
Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ...
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Jason Moore @moorejh.bsky.social · 20/04/2025
The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines www.nature.com/articles/s41... #vaccines #immunology #virology
nature.com
Combating vaccine revisionism - Nature Medicine
The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.
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TRAstonDrs @castltrastondrs.medsky.network · 23/04/2025
#Medsky🧪 #IDsky #pedsky #immunosky #publichealth Combining multiple vaccines may trigger stronger immune responses in fewer shots, potentially improving the efficacy of immunization programs. www.the-scientist.com/why-are-some...
the-scientist.com
Why are Some Vaccines Better Together?
Combining multiple vaccines may trigger stronger immune responses in fewer shots, potentially improving the efficacy of immunization programs.
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The French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social · 08/04/2025
A tour de force by the team of Marco Colonna describing in @cp-cell.bsky.social the role of "lymphoid RORγt+ Dendritic Cells in maintaining intestinal immune balance and preventing conditions like food allergies". www.cell.com/cell/fulltex...
cell.com
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This wo...
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Mariem Radhouani @mariemradhouani.bsky.social · 04/04/2025
I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs. 📄 Read the full study: www.science.org/doi/10.1126/... Let’s dive in 🧵 1/9
science.org
Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation
Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.
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Prof Sheena Cruickshank @sheencr.bsky.social · 27/03/2025
Patients being admitted to hospital in Texas with symptoms indicative of vitamin A toxicity- RFK jr has been promoting vitamin a and nutrition over and above vaccines to manage the measles outbreak in USA 🧪
cnn.com
Some measles patients in West Texas show signs of vitamin A toxicity, doctors say, raising concerns about misinformation | CNN
Doctors treating people hospitalized as part of a measles outbreak in Texas and New Mexico have also found themselves facing another problem: vitamin A toxicity.
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Salva Iborra @salva-iborra.bsky.social · 21/03/2025
New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...
cell.com
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections
The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary t...
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Prof Sheena Cruickshank @sheencr.bsky.social · 20/03/2025
Its a tragedy that an unvaccinated child died of measles but disgusting this being used for anti-vaccination propaganda. Vax is safe- measles is not & far from measles boosting your immune system it can wipe your immune memory making you more vulnerable to infxns
nbcnews.com
How the anti-vaccine movement weaponized a 6-year-old's measles death
Anti-vaccine influencers see the child’s death as proof — not of the danger of measles, but of their own debunked theories.
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Salva Iborra @salva-iborra.bsky.social · 21/03/2025
New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...
cell.com
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections
The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary t...
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KittyKatGirl😻🙏💞🐞 @mary1kathy.bsky.social · 13/03/2025
💯 RFK Jr. approved!
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Roychoudhuri Lab @roychoudhurilab.bsky.social · 05/03/2025
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
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Salva Iborra @salva-iborra.bsky.social · 12/03/2025
Pues que se la devuelva. #microbiota www.elespanol.com/ciencia/salu...
elespanol.com
Descubren el secreto de la longevidad de María Branyas para llegar a los 117 años: "Tenía la microbiota de una niña"
Una investigación que ha estudiado la microbiota de la catalana muestra que la vejez y la enfermedad no están necesariamente relacionadas. Más información: "La primera persona que cumplirá 150 años ya...
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Prof Sheena Cruickshank @sheencr.bsky.social · 12/03/2025
This is utterly irresponsible- RFK is not qualified- MMR is a safe vaccine which is well validated. Measles is a deadly disease. His words MATTER
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Salva Iborra @salva-iborra.bsky.social · 12/03/2025
📢 Nuevo estudio: La alimentación parcial con leche de fórumula se asocia con un 2.48x mayor riesgo de alergias alimentarias a los 12 meses (IC 95% 1.05-5.85), incluyendo alergia al cacahuete 🥜 🔬📊 www.medpagetoday.com/meetingcover...
medpagetoday.com
Formula Soon After Birth Linked to Food Allergy Risk
Observational study favors colostrum-only feeding in the first 3 days of life
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Salva Iborra @salva-iborra.bsky.social · 12/03/2025
🚨 New study reveals a bladder-blood immune barrier! 🦠🔬 Suburothelial perivascular macrophages (suPVMs) prevent UPEC from spreading into the bloodstream during UTIs. Loss of suPVMs increases the risk of bacteremia, but monocytes can replenish them! 🛡️💪 #UTI #Immunology www.cell.com/immunity/ful...
cell.com
A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination
Maintaining blood sterility during urinary tract infections is crucial for preventing urosepsis. Li et al. identify a subset of bladder-resident suburothelial perivascular macrophages that is essentia...
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Thiago Carvalho @cyrilpedia.bsky.social · 09/03/2025
'In rewilded mice, we observed B cells in circulation with increased signs of maturation, alongside heightened germinal center responses within secondary lymphoid organs. Rewilding also expanded B cells in the gut, which was accompanied by elevated systemic levels of IgG & IgM'
science.org
Rewilding catalyzes maturation of the humoral immune system
Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
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Salva Iborra @salva-iborra.bsky.social · 27/02/2025
The perils of RFK Junior's anti-vaccine leadership for public health www.thelancet.com/journals/lan...
thelancet.com
The perils of RFK Junior's anti-vaccine leadership for public health
With global measles cases surging more than 20% in a year, the spectre of an anti-vaccine leader like Robert F Kennedy Junior at the helm of US health policy has alarmed public health experts. Kennedy...
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Salva Iborra @salva-iborra.bsky.social · 27/02/2025
Primero se creía que las DCs inducían linfocitos Th2 mediante la secreción de IL-4. Después, por ausencia de una señal tipo 3. Un nuevo estudio sugiere que la clave está en la IL-2, presentada por DCs, a través de su propio receptor (CD25) a células T. #immunosky www.nature.com/articles/s41...
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