Reposted by Salva IborraAllergy EAACI @allergy-eaaci.bsky.social · 16/09/2026Respiratory inflammation spans a spectrum of upper and lower airway diseases, asthma, chronic rhinosinusitis, allergic and non-allergic rhinitis, and COPD, unified by overlapping type 2 and non-type 2 inflammatory mechanisms. 022
Reposted by Salva IborraVienna Airway Lab @viennaairwaylab.bsky.social · 10/09/2026Type 2 immunity evolved to defend against parasites and support tissue repair, but it also drives allergies/eosinophilic diseases. This review explores the dual role of Type2 immunity in health and disease. #Immunology #CRS #Allergy #Type2Immunity #Biologics 🔗 ino.to/V0T96Ke 043
Reposted by Salva IborraType 2 Immunity & Allergy Lab @jimenez-saiz-lab.bsky.social · 04/03/2026La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...okdiario.comAlergia al cacahuete: la ciencia mira a la boca para frenar la enfermedadLa saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá 011
Reposted by Salva IborraType 2 Immunity & Allergy Lab @jimenez-saiz-lab.bsky.social · 04/03/2026Muy agradecidos a El Mundo por divulgar nuestro trabajo en @cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia. www.elmundo.es/ciencia-y-sa...elmundo.esUna bacteria de la saliva 'protege' de la alergia al cacahuete, destruyendo en la boca las proteínas dañinasDos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las... 021
Reposted by Salva IborraDavid Sancho @sancholab.bsky.social · 14/02/2026Excessive #inflammation? We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful... #immunosky 194
Salva Iborra @salva-iborra.bsky.social · 26/02/2026🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde. 152
Reposted by Salva IborraWaggoner Lab @labwaggoner.bsky.social · 20/01/2026Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke www.researchsquare.com/article/rs-8... 0136
Reposted by Salva IborraThe French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social · 13/01/2026@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection rupress.org/jem/article/... 0116
Reposted by Salva IborraJon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵 34316
Salva Iborra @salva-iborra.bsky.social · 30/12/2025On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇 074
Reposted by Salva IborraPedro Papotto @ph-papotto.bsky.social · 19/12/2025Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv: www.biorxiv.org/content/10.6...biorxiv.orgBATF3 controls the homeostatic maintenance and function of innate-like γδ T cellsγδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses... 1114
Reposted by Salva IborraJournal of Experimental Medicine @jem.org · 05/12/2025Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/... (1/2) 🧵 👇 285
Reposted by Salva IborraMucosal Immunology @mucosalimmunol.bsky.social · 05/12/2025Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193... 1148
Reposted by Salva IborraWaggoner Lab @labwaggoner.bsky.social · 05/12/2025mRNA vaccines 💉don't cause death but prevent it Massive study from France showed that mRNA vaccines reduced deaths and saved lives @mahmoudzureik.bsky.social @jama.com jamanetwork.com/journals/jam... 816953
Salva Iborra @salva-iborra.bsky.social · 05/12/2025Fascinating study revealing how NK cells can eliminate intracellular E. coli infecting the urothelium. -Just a comment on the NK depletion experiment, NK1.1 is also expressed by ILC1s, NKT and most γδ T1 cells (IFN-γ producers). 000
Salva Iborra @salva-iborra.bsky.social · 27/11/2025👇No os lo perdáis! Hoy, a las 19:00 h, Oscar Palomares hablará en Allergotrends (Inmunotek) sobre los"Avances en inmunidad innata entrenada en inmunoterapia específica de alérgeno: Vacunas bacterianas para la prevención y tratamiento del asma alérgica". eventos.quodem.com/allergotrend... 000
Salva Iborra @salva-iborra.bsky.social · 26/11/2025Gracias @larazonlr.bsky.social ! Por hacerse eco de nuestra investigación. www.larazon.es/salud/que-ma...larazon.es¿Por qué es más difícil reinfectarnos de un virus que ya hemos tenido?Científicos españoles descubren cómo refuerza el sistema inmunitario la defensa del organismo frente a patógenos como la gripe 000
Reposted by Salva IborraPayal Yokota @payalyokota.bsky.social · 19/11/2025..cross your 't's folks.. here's how! www.nature.com/articles/s41...nature.comGuidelines for T cell nomenclature - Nature Reviews ImmunologyThis Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo... 2108
Reposted by Salva IborraCaetano Reis e Sousa @reisesousalab.bsky.social · 13/11/2025Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage. 0133
Reposted by Salva IborraRockefeller University Press @rupress.org · 25/11/2025In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/... #MucosalImmunology 021
Reposted by Salva IborraWaggoner Lab @labwaggoner.bsky.social · 25/11/2025pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection @jem.org rupress.org/jem/article-... 021
Salva Iborra @salva-iborra.bsky.social · 25/11/2025Excited to share our new paper in @jem.org! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno 🧵👇1/6 193
Reposted by Salva IborraWaggoner Lab @labwaggoner.bsky.social · 30/08/2025@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses www.biorxiv.org/content/10.1... 062
Reposted by Salva IborraelDiario.es @eldiario.es · 24/08/2025Aemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registroseldiario.esAemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registrosLa Agencia de Meteorología española advierte de que los datos registrados y las previsiones hasta el día 31 de este mes hacen prever que este será uno de los veranos más calurosos de la historia. "¿Y ... 317070
Reposted by Salva IborraAngélica Cuapio @dracuapio.bsky.social · 06/07/2025Our latest review: Inborn errors of immunity affecting the MHC class I pathway for antigen presentation url: rupress.org/jhi/article/...rupress.orgInborn errors of immunity affecting the MHC class I pathway for antigen presentation | Journal of Human Immunity | Rockefeller University PressThe paper discusses rare inborn errors of immunity affecting MHC class I antigen processing, leading to infections and skin lesions, often misdiagnosed as 031
Reposted by Salva IborraEuropean Research Council (ERC) @erc.europa.eu · 17/07/2025🧬 A new study by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) links the gut-derived metabolite imidazole propionate (ImP) to #atherosclerosis. The research explores ImP as a potential marker & contributor to early disease development. 👉 europa.eu/!wBktrm 1123
Reposted by Salva IborraThe LeibundGut-lab @lableibundgut.bsky.social · 03/06/2025Are you interested in antifungal immunity in the skin? Then, this postdoc position may be of interest to you 👇 #Immunology #immunosky 032
Reposted by Salva IborraDiscovery Immunology @discovimmunol.bsky.social · 04/06/2025Wild mice reveal surprising immune system differences! 🐭🔬 Discover how wild mouse bone marrow composition contrasts with lab mice, unlocking new immunology insights. Read here: bit.ly/4jtlZeC #Immunology #InnateImmunity 092
Reposted by Salva IborraYannick Alexandre @yannick-alexandre.bsky.social · 05/06/2025I’m pleased to share my latest work, published in Science Advances. In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections. #immunology #immunosky www.science.org/doi/10.1126/...science.orgSplenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memoryFibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory. 163
Reposted by Salva IborraProf Sheena Cruickshank @sheencr.bsky.social · 05/06/2025As the USA shuts down programs to develop HIV vaccines, we have exiting news from Australia of new work delivering RNA encoding bits of HIV to T cells #Immunosky 🧪🧵theguardian.comBreakthrough in search for HIV cure leaves researchers ‘overwhelmed’Exclusive: Melbourne team demonstrates way to make the virus visible within white blood cells, paving the way to fully clear it from the body 10430120
Reposted by Salva IborraProf Sheena Cruickshank @sheencr.bsky.social · 03/06/2025More evidence of the link between microbiome and immune function as excess antibiotics impair response to vaccines in infants and those with Bifodibacterium in the gut did better with vaccine responses🧪nature.comNeonatal antibiotics impair infant vaccine responses - Nature Reviews ImmunologyA prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and... 27525
Reposted by Salva IborraProf Sheena Cruickshank @sheencr.bsky.social · 04/06/2025Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪nature.comSuccinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature ImmunologyFang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ... 23812
Reposted by Salva IborraJason Moore @moorejh.bsky.social · 20/04/2025The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines www.nature.com/articles/s41... #vaccines #immunology #virologynature.comCombating vaccine revisionism - Nature MedicineThe scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines. 15317
Reposted by Salva IborraTRAstonDrs @castltrastondrs.medsky.network · 23/04/2025#Medsky🧪 #IDsky #pedsky #immunosky #publichealth Combining multiple vaccines may trigger stronger immune responses in fewer shots, potentially improving the efficacy of immunization programs. www.the-scientist.com/why-are-some...the-scientist.comWhy are Some Vaccines Better Together?Combining multiple vaccines may trigger stronger immune responses in fewer shots, potentially improving the efficacy of immunization programs. 13812
Reposted by Salva IborraThe French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social · 08/04/2025A tour de force by the team of Marco Colonna describing in @cp-cell.bsky.social the role of "lymphoid RORγt+ Dendritic Cells in maintaining intestinal immune balance and preventing conditions like food allergies". www.cell.com/cell/fulltex...cell.comRorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigensDeleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This wo... 051
Reposted by Salva IborraMariem Radhouani @mariemradhouani.bsky.social · 04/04/2025I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs. 📄 Read the full study: www.science.org/doi/10.1126/... Let’s dive in 🧵 1/9science.orgEosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammationStaphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation. 58121
Reposted by Salva IborraProf Sheena Cruickshank @sheencr.bsky.social · 27/03/2025Patients being admitted to hospital in Texas with symptoms indicative of vitamin A toxicity- RFK jr has been promoting vitamin a and nutrition over and above vaccines to manage the measles outbreak in USA 🧪cnn.comSome measles patients in West Texas show signs of vitamin A toxicity, doctors say, raising concerns about misinformation | CNNDoctors treating people hospitalized as part of a measles outbreak in Texas and New Mexico have also found themselves facing another problem: vitamin A toxicity. 22320194
Reposted by Salva IborraSalva Iborra @salva-iborra.bsky.social · 21/03/2025New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...cell.comTrained immunity-based mucosal immunotherapies for the prevention of respiratory infectionsThe devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary t... 052
Reposted by Salva IborraProf Sheena Cruickshank @sheencr.bsky.social · 20/03/2025Its a tragedy that an unvaccinated child died of measles but disgusting this being used for anti-vaccination propaganda. Vax is safe- measles is not & far from measles boosting your immune system it can wipe your immune memory making you more vulnerable to infxnsnbcnews.comHow the anti-vaccine movement weaponized a 6-year-old's measles deathAnti-vaccine influencers see the child’s death as proof — not of the danger of measles, but of their own debunked theories. 69629
Salva Iborra @salva-iborra.bsky.social · 21/03/2025New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...cell.comTrained immunity-based mucosal immunotherapies for the prevention of respiratory infectionsThe devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary t... 052
Reposted by Salva IborraKittyKatGirl😻🙏💞🐞 @mary1kathy.bsky.social · 13/03/2025💯 RFK Jr. approved! 243154222833
Reposted by Salva IborraRoychoudhuri Lab @roychoudhurilab.bsky.social · 05/03/2025Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U 210445
Salva Iborra @salva-iborra.bsky.social · 12/03/2025Pues que se la devuelva. #microbiota www.elespanol.com/ciencia/salu...elespanol.comDescubren el secreto de la longevidad de María Branyas para llegar a los 117 años: "Tenía la microbiota de una niña"Una investigación que ha estudiado la microbiota de la catalana muestra que la vejez y la enfermedad no están necesariamente relacionadas. Más información: "La primera persona que cumplirá 150 años ya... 010
Reposted by Salva IborraProf Sheena Cruickshank @sheencr.bsky.social · 12/03/2025This is utterly irresponsible- RFK is not qualified- MMR is a safe vaccine which is well validated. Measles is a deadly disease. His words MATTER 512332
Salva Iborra @salva-iborra.bsky.social · 12/03/2025📢 Nuevo estudio: La alimentación parcial con leche de fórumula se asocia con un 2.48x mayor riesgo de alergias alimentarias a los 12 meses (IC 95% 1.05-5.85), incluyendo alergia al cacahuete 🥜 🔬📊 www.medpagetoday.com/meetingcover...medpagetoday.comFormula Soon After Birth Linked to Food Allergy RiskObservational study favors colostrum-only feeding in the first 3 days of life 000
Salva Iborra @salva-iborra.bsky.social · 12/03/2025🚨 New study reveals a bladder-blood immune barrier! 🦠🔬 Suburothelial perivascular macrophages (suPVMs) prevent UPEC from spreading into the bloodstream during UTIs. Loss of suPVMs increases the risk of bacteremia, but monocytes can replenish them! 🛡️💪 #UTI #Immunology www.cell.com/immunity/ful...cell.comA bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen disseminationMaintaining blood sterility during urinary tract infections is crucial for preventing urosepsis. Li et al. identify a subset of bladder-resident suburothelial perivascular macrophages that is essentia... 030
Reposted by Salva IborraThiago Carvalho @cyrilpedia.bsky.social · 09/03/2025'In rewilded mice, we observed B cells in circulation with increased signs of maturation, alongside heightened germinal center responses within secondary lymphoid organs. Rewilding also expanded B cells in the gut, which was accompanied by elevated systemic levels of IgG & IgM'science.orgRewilding catalyzes maturation of the humoral immune systemReleasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system. 0174
Salva Iborra @salva-iborra.bsky.social · 27/02/2025The perils of RFK Junior's anti-vaccine leadership for public health www.thelancet.com/journals/lan...thelancet.comThe perils of RFK Junior's anti-vaccine leadership for public healthWith global measles cases surging more than 20% in a year, the spectre of an anti-vaccine leader like Robert F Kennedy Junior at the helm of US health policy has alarmed public health experts. Kennedy... 000
Salva Iborra @salva-iborra.bsky.social · 27/02/2025Primero se creía que las DCs inducían linfocitos Th2 mediante la secreción de IL-4. Después, por ausencia de una señal tipo 3. Un nuevo estudio sugiere que la clave está en la IL-2, presentada por DCs, a través de su propio receptor (CD25) a células T. #immunosky www.nature.com/articles/s41... 131