Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

Sánchez-Martínez and Rondeau et al. reveal that human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis. This study...

In the current issue of Cell Host & Microbe, Sánchez-Martínez et al. demonstrate that oral and small-intestine bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens. This study provides insights into microbial mechanisms underlying food-induced anaphylaxis and may point to new directions for advancing food allergy therapy.

Nature Reviews Microbiology, Published online: 20 March 2026; doi:10.1038/s41579-026-01300-3This study shows that some human microbiota bacteria can metabolize immunodominant peanut allergens, thus modulating IgE-mediated anaphylaxis.

ALT: a woman looks through a microscope in a lab

Scientists identify bacteria that digest allergy-triggering compounds in peanuts, which can be life-threatening to those with allergies.

Izawa et al. identify sphingomyelin and ceramide species as ligands for CD300d3 and CD300f. CD300d3 enhances IgE-mediated murine mast cell activation via its ligands, whereas CD300f inhibits it. Mast ...

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

Sánchez-Martínez and Rondeau et al. reveal that human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis. This study...

Dos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las...

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá

Un equipo científico de España y Canadá ha demostrado que ciertos microorganismos presentes en la boca influyen en la respuesta del sistema inmunitario frente a este alimento. Los resultados revelan nuevas vías de prevención centradas en el equilibrio de la microbiota.

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

The cellular context interacts with genetic circuits, decisively defining their performance. However, contextual dependencies (the interplay between the host and the circuit) are often difficult to en...

Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.

Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens