Dupilumab provides rapid and sustained clinical benefit in CRSwNP, independent of prior sinus surgery status. However, it should be noted that the influence of surgical extent could not be assessed in this cohort.

Aspirin-exacerbated respiratory disease (AERD) is a severe endotype of chronic rhinosinusitis with nasal polyps, asthma, and respiratory reactions to COX-1 inhibitors. Aspirin desensitization followed...

An expanded atlas of human cells maps the expression of nearly all human transcription factors across 701 cell-type/tissue combinations and uncovers the heterogeneous nature of senescence across tissu...

This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector-related mol...

Lipids generated by oxidative stress and their effects on immunity and cancer are reviewed.

Nature Reviews Immunology, Published online: 10 August 2026; doi:10.1038/s41577-026-01337-8Ferroptosis, an iron-dependent form of cell death, is emerging as a key regulator of T cell biology. This Review examines how iron, lipid and redox pathways shape T cell development, function and survival, and explores how manipulating ferroptosis could enhance cancer immunotherapy, improve adoptive cell therapies, and enable more precise immune interventions.

Unlike in other tissues, lung-resident memory T cell populations are not well maintained in mice. Here the authors show that this is not the case in human lungs, where tissue-resident memory T cells s...

Nature Reviews Immunology, Published online: 30 July 2026; doi:10.1038/s41577-026-01346-7Stimulating the auricular branch of the vagus nerve can suppress allergic airway inflammation in mice.

Macrophage plasticity and function involve precise regulation of transcriptional programs. Tzerpos et al. find that the transcription factor BACH1 establishes early chromatin accessibility while maint...

This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high-dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses...

The phase 3 WAYPOINT study (NCT04851964) showed that tezepelumab improved outcomes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) including nasal polyp size, nasal congestion and s...

Background To systematically evaluate the local biomarkers correlated with olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). Methods A systematic review was conducted in CINAHL, Cochrane ...

Biomedical research is increasingly constrained by repetitive, fragmented workflows that slow discovery. We introduce Biomni, a general-purpose biomedical artificial intelligence agent that autonomous...

Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochond...

Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate med.....

Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease-specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of t...