On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇
@ph-papotto.bsky.socialIsn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv:
www.biorxiv.org/content/10.6...
biorxiv.org
BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells
γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...