Summary: This Review discusses how developmental and stem cell studies of the notochord can reveal key insights into spine formation and intervertebral disc development and maintenance, providing new ...

Por fin ponemos cara al origen de esta idea: María Climent 👏🏼Doctora, profesora e investigadora en la Universidad de Zaragoza, desarrolla su trabajo en el ámbito de la anatomía, la patología veterinaria y la biología del desarrollo, combinando investigación y docencia universitaria.Su interés por la divulgación junto a su conocimiento en anatomía y epigenética de los ovocitos, le hizo ver la necesidad de acercar datos reales y rigurosos a la sociedad sobre fertilidad femenina. Así nace este proyecto que, gracias a su iniciativa y a la colaboración de muchas personas, pronto se transformará en un cortometraje que estará al alcance de todo el mundo ✨🌎••At last, we can put a face to the person behind this idea: María Climent 👏🏼She’s a doctor, professor, and researcher at the University of Zaragoza, working in anatomy, veterinary pathology, and developmental biology, combining research with teaching.Her passion for science communication, together with her expertise in anatomy and oocyte epigenetics, made her realize the need to share clear, evidence-based information about female fertility. That’s how this project was born, an idea that, thanks to her initiative and the collaboration of many others, will soon become a short film available to everyone ✨🌎#ReproducciónFemenina #DivulgaciónCientífica #Cortometraje #SaludFemenina #CulturaCientífica UnizarView all comments

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AbstractSTUDY QUESTION. Is there a relationship between the mitochondrial activity and the meiotic progression of oocytes from germinal vesicle (GV) to met

A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accel...

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...

Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...

SIMPLE-seq measures both 5-methylcytosine and 5-hydroxymethylcytosine at base resolution in single cells.

Techniques for genome-wide epigenetic profiling have been undergoing accelerated development toward recovery of high-quality data from bulk and single cell samples. DNA-protein interactions have tradi...

Mice injected with a microRNA molecule lived longer and had fewer markers of ageing, but it’s not yet known if the treatment would work in people.

Here, the authors identify that reduced DNA methylation in developing germ cells alters nucleosome retention in sperm and allows H3K4me3 establishment on paternal DNA in early embryos, highlighting a ...

Nature Reviews Genetics, Published online: 13 January 2025; doi:10.1038/s41576-024-00807-wEpigenetic clocks based on DNA methylation data are machine learning tools used to estimate chronological and biological age. The authors review computational and…