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Meghana Oak @meghana-oak.bsky.social · 22/12/2025

After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!

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Reposted by Meghana Oak

Epigenetics at Helmholtz Munich @epihmgu.bsky.social · 25/02/2025

🚀 PREPRINT ALERT! 🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development. 👏 Congratulations @meghana-oak.bsky.social & rest of authors. 📑 👀 shorturl.at/6MIRn 🔎 #OpenPeerReview

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Reposted by Meghana Oak

The Groth lab @grothlab.bsky.social · 19/02/2025

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

tinyurl.com

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

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Meghana Oak @meghana-oak.bsky.social · 19/02/2025

Looking forward to a great discussion!

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Meghana Oak @meghana-oak.bsky.social · 22/01/2025

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here: doi.org/10.1101/2025... 👇 Highlights below

doi.org

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development

In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

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