Polymath ecologist whose research and textbooks integrating ecology and evolution have inspired generations of students.

AbstractBackground:. Red meat consumption is a risk factor for colorectal cancer and has been linked to tumor alkylating DNA damage. rs16906252-T is a cis expression quantitative trait locus variant a...

Britain’s postwar sugar rationing was an accidental experiment. Decades on, it’s revealing how early diet shapes cancer risk, ageing and eating habits for life.

Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic reprogramming, yet wheth...

A new study offers the first systematic test of whether DNA methylation clocks behave the way a surrogate endpoint for aging should, responding to genuine clinical benefit and remaining stable when th...

The psychedelic psilocybin reorganizes brain activity into structured, context-aligned patterns that integrate internal and external processing, providing a neural basis for the felt continuity between self and world, elucidating how the psychedelic state translates into psychological change.

Human brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, following human-specific endogenous programs, even outside the context of the organism.

Inspired by long-lived animals — and human centenarians — researchers are hunting for ways to enhance DNA repair and extend healthspan.

Analysis of one million diverse genomes yields mutations associated with lower risk of diabetes, heart disease and other ‘cardiometabolic’ conditions.

Abstract. Intergenerational and transgenerational fitness effects can shape evolutionary processes. Theoretically, however, intergenerational and transgene

The ovarian stroma becomes increasingly stiff with age, impairing ovarian function. The mechanisms that underlie this process are only partly understood. Here, the authors show that IL-11, which is el...

Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...

Drawing on empirical evidence and evolutionary theory, we argue that biological sex is most coherently defined as a binary classification of reproductive strategies rooted in anisogamy (the productio...

Robert Ricklefs, a giant of ecology, passed away on Sunday. It is hard to overstate the extensive impact Bob had on the field. He was elected a member of the National Academy of Sciences in the US,…

A review article now published in Nature Reviews Genetics brings together evolutionary theory, comparative genomics and large-scale human genetics to explain why we age and why aging rates differ among individuals and species.

Neural crest (NC) multipotent stem cells give rise to many tissues including most of the peripheral nervous system, pigment cells and the craniofacial mesenchyme and skeleton. During gastrulation and ...

Genome-wide analyses indicate that accumulation of mitochondrial DNA mutations, a hallmark of ageing, may be caused by cryptic replication errors, which act as passenger mutations that eventually become detectable with age owing to age-related somatic mosaicism, rather than oxidative damage.

View details and apply for this Impact Lecturer in Microbiology (ATR1737) vacancy in University of East Anglia. Faculty of Science School of Biological Sciences Impact Lecturer in Microbiology...

Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says longevity researcher Saul Newman.

Wildlife crime is a multi-billion-dollar industry. After drug, arms, and human trafficking, the illegal trade in wildlife is among the most lucrative forms of crime, with an estimated value of over $2...

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications for chemoresistant cancers.

Supplement users have lower epigenetic biological age than non-users. Several supplements or supplement classes are associated with some benefit on epigenetic age in either cross-sectional or longitu...

Males and females often live different lengths of time, but why remains unclear. Here, the authors present a theoretical model showing that trade-offs between survival and reproduction, together with ...

In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, lin...

In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...

Drug arrives years after pandemic’s peak, but could still offer critical protection to vulnerable populations.

Modern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary geneti...

Aging has effects on the immune system that are similar in men and women, but also reshapes their immune systems in unique, sex-specific ways, however these differences are rarely taken into…

The ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules. The changes, intended to manage the ...

Interventions to extend lifespan and healthspan are of major interest, but such interventions may affect male and female organisms differently. Whethe…

Paterna Biosciences says it has determined the set of instructions needed to turn sperm-making stem cells into "normal, mature" sperm.