The process of DNA replication is inherently asymmetric. While the leading strand is synthesized continuously, the lagging strand is copied in small fragments, the Okazaki fragments, requiring the ...

The interaction of proteins with DNA during replication, transcription, and repair is precisely required to faithful transmission of genetic information. While transient protein–DNA interactions are e...

Los investigadores Andrés Aguilera, catedrático del Departamento de Genética de la Universidad de Sevilla y miembro de CABIMER, y Jesús Campos Manzano, investigador del CSIC en el Instituto de Investi...

Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the ph...

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

La etóloga británica Jane Goodall ha fallecido a los 91 años de edad en la ciudad estadounidense de...

This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...

Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. Th...

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

El hallazgo ha sido liderado por el departamento de Genética de la Universidad de Sevilla y el Instituto Cabimer

Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.

Arranca el segundo día de CABIMER en la #23Feriadelaciencia. ¡Visítanos y conócenos en el puesto 51! @cabimer https://t.co/bYqnXHUNLl

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!

HMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair.

Chromosomal instability (CIN) drives cancer progression through diverse mechanisms. The authors review the molecular consequences of CIN in advanced cancer, such as genomic and phenotypic heterogeneit...

Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at

The USP37 deubiquitylase is important for mammalian cells to survive DNA replication stress but the underlying mechanisms are unknown. Here we demonstrate that USP37 binds the CDC45-MCM-GINS (CMG) hel...

Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that...