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imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

YouTube video by Fiona MacLeod

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

ALT: a penguin is reading a newspaper while another penguin looks on

Kao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.

m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated mRNA degradation, a process that highlights the ribosome as a critical sensor linking translation dynamics to m6A-dependent mRNA metabolism.

Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

A recent study from Hannah Garner, Ph.D. and new member of the Rosalind and Morris Goodman Cancer Institute (GCI), published in Cancer Cell, showed that neutrophil precursors located in the bone marrow receive signals from mammary tumours and promote metastasis.

Understanding the mechanisms that facilitate early events in metastatic seeding is key to developing therapeutic approaches to reduce metastasis – the leading cause of cancer-related death. Using whol...

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...