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David Landeira

@davidlandeira.bsky.social
150 followers 121 following 23 posts

Cells forget. We’re learning how to make them remember. @GENYO University of Granada, Spain. www.landeiralab.ugr.es

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Reposted by David Landeira
Rob Klose @robklose.bsky.social · 30/09/2026
Come join us April 2027 for the next instalment of the EMBL Chromatin and Epigenetics meeting. Great invited speakers and lots of talks selected from abstracts! It will be a fantastic meeting (despite the egregious nucleosome images...)
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Epigenetics Podcast @epigeneticspod.bsky.social · 28/09/2026
In the most recent episode we speak with @robklose.bsky.social, Professor of Genetics at the University of Oxford, about how CpG islands help control gene expression and chromatin regulation during development. #podcast #epigenetics Listen here: activemotif.com/podcasts-rob...
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David Landeira @davidlandeira.bsky.social · 22/09/2026
Last spots available to join us in our workshop in transcriptional memory in health and disease, 20th-22nd October, in Baeza, Spain. Reduced rates of 250 € are available for young researchers! Application deadline 27th of September. Come and join us! @pablonavarrolab.bsky.social
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Prof. Feynman @proffeynman.bsky.social · 12/09/2026
If you cannot explain it in simple terms, you don't understand it well enough.
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John Greally @greally.bsky.social · 13/09/2026
Looking forward to hearing talks from @pablonavarrolab.bsky.social, @leonidmirny.bsky.social, Petra Hajkova, Amanda Fisher, Wolf Reik and others. Located in the ancient town of Baeza in Andalusia in Spain, it should be a beautiful retreat 20-22 October.
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John Greally @greally.bsky.social · 13/09/2026
One week left to register, Workshop Transcriptional memory in health and disease: www.unia.es/estudios-y-a... 15 speakers, plus only 50 participants, 3 days of sharing of insights and ideas with leaders in the field.
unia.es
Workshop Transcriptional memory in health and disease
The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...
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David Landeira @davidlandeira.bsky.social · 03/09/2026
Tesis Doctoral en Epigenética y Envejecimiento (Beca FPU) ¿Podemos revertir el envejecimiento mediante modulación epigenética? Buscamos graduados/as en Ciencias Biomédicas con expediente > 8.5/10 para unirse al Epigenetic Memory in Disease Lab en GENYO (Granada). Por favor comparte.
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David Landeira @davidlandeira.bsky.social · 03/09/2026
Fully Funded 4-Year PhD Position (FPI Contract)! Is the loss of epigenetic memory the driver of aging? Join the Epigenetic Memory in Disease Lab at GENYO (Granada, Spain). Please repost.
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David Landeira @davidlandeira.bsky.social · 31/08/2026
Want to present your research alongside top global experts in epigenetics? Places are still available for posters and selected short talks at Transcriptional Memory in Health and Disease in Baeza, Spain! Deadline: Sept 20th. Limited to 50 participants. Secure your spot!
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Prof. Feynman @proffeynman.bsky.social · 03/08/2026
The pleasure isn't in being right. It's in the finding out.
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Waggoner Lab @labwaggoner.bsky.social · 03/08/2026
Perspective @naturerevgenet.bsky.social @nireynon.bsky.social Embracing non-linearity in human ageing www.nature.com/articles/s41...
nature.com
Embracing non-linearity in human ageing - Nature Reviews Genetics
Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such e...
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Akis (Argyris) Papantonis @akispapantonis.bsky.social · 21/07/2026
Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...
nature.com
Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging
Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...
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Jose A. Esteban @jaestebancbm.bsky.social · 16/07/2026
Nos hacen notar desde el Ministerio @cienciagob.bsky.social que desde el 2018 ha habido una subida de presupuesto del 40%. Sin duda, desde que entró este gobierno la subida ha sido notable. Pero amigos... ¡es que nos hemos estancado! ¡Y la Ciencia sigue! @ageinves.bsky.social
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Jose A. Esteban @jaestebancbm.bsky.social · 17/07/2026
La financiación de los proyectos de investigación se está estancando. ¡Pero la ciencia no se para! Si no se hace aquí, se hará en otra parte... 😕 elpais.com/ciencia/2026...
elpais.com
¿Qué ciencia puede realizarse con 50.000 euros al año?
“Esta limitación presupuestaria dificulta afrontar los experimentos complejos que hoy exige buena parte de la investigación en múltiples campos”, denuncian los autores
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Marisol Soengas @msmelanoma.bsky.social · 17/07/2026
Tribuna con @xrbustelo.bsky.social, @jaestebancbm.bsky.social, JM Torralba y J Gil sobre la resolución provisional de los proyectos PID (“Plan Nacional”), con media de 50.000 euros/proyecto/año (costes directos). Hay otras convocatorias, pero esta es básica e insuficiente elpais.com/ciencia/2026...
elpais.com
¿Qué ciencia puede realizarse con 50.000 euros al año?
“Esta limitación presupuestaria dificulta afrontar los experimentos complejos que hoy exige buena parte de la investigación en múltiples campos”, denuncian los autores
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Pereira Lab @cellreprolab.bsky.social · 08/07/2026
1/2 The Immunity by Design: In Vivo Immune Cell Engineering Conference introduces Session 1: Cell Engineering & Reprogramming. The Pereira lab will share the stage with Judit Svensson Arvelund and Özcan Met to discuss emerging approaches in immune cell engineering and cancer immunotherapy.
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Flora Paldi @fpaldi.bsky.social · 14/04/2025
Our new review in @cp-trendscellbio.bsky.social is now online! We discuss the connection between the epigenome, 3D genome folding, gene expression and cellular memory, specifically in loop extrusion-independent contexts.
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Pablo Navarro @pablonavarrolab.bsky.social · 03/06/2026
The list of speakers is very nice, mixing the two fields in synergy. Many abstracts will be selected for oral presentation.
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Science Magazine @science.org · 10/06/2026
"The goal is not just more capable AI, but AI that is more intelligible, accountable, and aligned with human aims. The window for achieving that future is narrowing," argue Eric Horvitz and Robert West in a new #ScienceEditorial. scim.ag/4oaIYig
A quote reads: "Preserving human agency must ... remain a central goal." Attributed to Eric Horvitz and Robert West.
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Aurora Ruiz-Herrera @aruizherrera.bsky.social · 10/06/2026
🚨 New paper in Nature 🚨 Thrilled to be part of this fascinating collaborative study! 👉 SIRT7 regulates dosage compensation and safeguards the female X chromosome rdcu.be/fnEZQ A great example of how chromatin regulation continues to reveal unexpected layers of genome control!
rdcu.be
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Nature - SIRT7 safeguards X-chromosome integrity and dosage balance with autosomes.
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David Landeira @davidlandeira.bsky.social · 08/06/2026
Excited to announce the International Workshop "Transcriptional memory in health & disease" in Baeza (Spain) this Oct 20-22! Discover how chromatin & networks encode cellular memory with top speakers. unia.es/estudios-y-a... pic.x.com/fjhBUrtRgb
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Prof. Feynman @proffeynman.bsky.social · 24/05/2026
If you cannot explain it in simple terms, you don't understand it well enough.
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Richard Sever @richardsever.bsky.social · 24/05/2026
"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...
journals.biologists.com
Interview with Noboru Mizushima – President of the Japan Society for Cell Biology
Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...
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Nature @nature.com · 30/03/2026
Nature research paper: Dogs were widely distributed across western Eurasia during the Palaeolithic go.nature.com/3NNGybD
go.nature.com
Dogs were widely distributed across western Eurasia during the Palaeolithic - Nature
Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.
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Nature @nature.com · 13/03/2026
The rates of more than a dozen cancers are increasing among adults under the age of 50. What are the reasons behind it? go.nature.com/4cKxhLN
go.nature.com
Why are so many young people getting cancer? What the data say
Clues to a modern mystery could be lurking in information collected generations ago.
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Rob Klose @robklose.bsky.social · 13/03/2026
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
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Sara R Heras @herassr.bsky.social · 05/03/2026
Graphical abstract from our new paper in Nucleic Acids Research with @saramaciasrna.bsky.social 🧬 DGCR8 prevents accumulation of endogenous dsRNA derived from Alu elements within mRNAs, avoiding aberrant activation of the interferon response. academic.oup.com/nar/article/...
academic.oup.com
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev
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David Landeira @davidlandeira.bsky.social · 21/02/2026
muyinteresante.okdiario.com/ciencia/para...
muyinteresante.okdiario.com
Científicos, Influencers y la paradoja de la confianza: por qué cuanto más rigurosa es la ciencia, menos creemos en ella
¿Por qué confiamos antes en el consejo de un extraño en TikTok que en una institución médica centenaria? Un profundo análisis publicado en The Lancet revela que el rigor científico está perdiendo la b...
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David Landeira @davidlandeira.bsky.social · 13/01/2026
¿Quieres descifrar los mecanismos epigenéticos del rejuvenecimiento celular? Si tienes un expediente académico superior a 8.5 y buscas realizar tu tesis doctoral en un entorno de excelencia (GENYO, Granada), contáctanos para solicitar becas FPU/Junta. Deadline inminente! ⏩
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Oded Rechavi @odedrechavi.bsky.social · 09/01/2026
"Freezing forgetting in C. elegans to extend memory retention" - check out the "research briefing" about our new paper in Nature Neuro rdcu.be/eYlXY
rdcu.be
Client Challenge
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Cedric Feschotte @cedricfeschotte.bsky.social · 07/01/2026
New Year, New Paper!🎊 Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system www.biorxiv.org/content/10.6... Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
biorxiv.org
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
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David Landeira @davidlandeira.bsky.social · 02/01/2026
x.com/i/status/200...
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David Landeira @davidlandeira.bsky.social · 02/01/2026
x.com/i/status/200...
x.com
Jeffrey West on X: "Another great short essay, by Paul Nurse, 2021: "Theorizing should be encouraged, and theories should be included in experimental papers to put data in context." https://t.co/UJF9ENNX1Q" / X
Another great short essay, by Paul Nurse, 2021: "Theorizing should be encouraged, and theories should be included in experimental papers to put data in context." https://t.co/UJF9ENNX1Q
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Rob Klose @robklose.bsky.social · 11/12/2025
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
biorxiv.org
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
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Rada-Iglesias Lab @radaiglesiaslab.bsky.social · 06/11/2025
OFERTA DE EMPLEO (por favor difundir): Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas 👇
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Science Magazine @science.org · 22/12/2025
NIH Director Jay Bhattacharya has struggled to convince observers he has the agency’s best interests in mind—and is truly in charge. scim.ag/3MMXDSh
scim.ag
Will NIH’s new director reform his agency—or destroy it?
Jay Bhattacharya is struggling to make the case he’s in charge and has the agency’s best interests at heart
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Anders Sejr Hansen @andersshansen.bsky.social · 22/12/2025
Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:
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Michelle Percharde @mpercharde.bsky.social · 22/12/2025
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....
science.org
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
You have to enable JavaScript in your browser's settings in order to use the eReader.
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Kyle Eagen @kyleeagen.bsky.social · 23/12/2025
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division! www.nature.com/articles/s41...
nature.com
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 21/12/2025
ChatGPT no pasa la prueba: así pone en peligro la vida de menores.
elpais.com
ChatGPT no pasa la prueba: así pone en peligro la vida de menores
EL PAÍS experimenta con tres cuentas ficticias los filtros de OpenAI para proteger a los niños. Expertos en salud mental critican el resultado, porque las medidas son insuficientes y no alertan a los ...
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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 11/12/2025
Ponencia de Ángel Carracedo en las XIII Jornadas científicas de Genyo.
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Fundacion Atapuerca @fatapuerca.bsky.social · 24/11/2025
📖 El 24 de noviembre de 1859 se publicó #ElOrigenDeLasEspecies de #Darwin donde se establece su teoría de la #Evolución por #SelecciónNatural 🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental. #díamundialdelaevolución
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Waggoner Lab @labwaggoner.bsky.social · 29/10/2025
Origins of chromosome instability unveiled by coupled imaging and genomics @nature.com www.nature.com/articles/s41...
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Nature @nature.com · 26/10/2025
There is one point of agreement among both enthusiasts and sceptics: the future has already arrived go.nature.com/48M5Xuu
go.nature.com
Universities are embracing AI: will students get smarter or stop thinking?
Nature - Millions of students arriving at campuses are now using artificial intelligence. Worries abound.
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Rob Klose @robklose.bsky.social · 17/10/2025
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 24/09/2025
Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...
labanda.canalsur.es
El envejecimiento empieza en el embrión, antes de nacer
El programa infantil de Canal Sur. Desde 1994 para todos los niños andaluces. ¡En La Banda Tú Mandas!
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David Landeira @davidlandeira.bsky.social · 22/09/2025
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
canal.ugr.es
A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR
This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...
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David Landeira @davidlandeira.bsky.social · 12/09/2025
When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf
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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 10/09/2025
🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)
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David Landeira @davidlandeira.bsky.social · 10/09/2025
Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...
canal.ugr.es
Un nuevo estudio sugiere que el envejecimiento empieza en las primeras fases del desarrollo del embrión, y no solo en la vida adulta - Canal UGR
Este trabajo de la UGR, publicado en Nature Communications, abre un paradigma en biomedicina al examinar el papel de la proteína BMAL1 en la vejez y el desarrollo de enfermedades
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