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Duxin lab

@duxinlab.bsky.social
329 followers 309 following 41 posts

Diving into genome replication and stability research Collaborating shoulder to shoulder with Xenopus frogs 🐸 at @bric-ucph.bsky.social, @ucph.bsky.social

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Replifate Consortium @replifate.bsky.social · 16/06/2026
The countdown to the RepliFate Final Conference is officially on, and the scientific programme is now live: replifate.eu/event/intern... #Munich2026 #MSCA #LifeScience #DNAReplication #GenomeStability #Chromatin
replifate.eu
Events for June 2026
Monday, 6th July 2026 09:00 09:10 Welcome & Opening Remarks Organising committee Session 1. Replication initiation and chromatin feature (1/2)  Chair: Juan Méndez (Spanish National Cancer Re...
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Replifate Consortium @replifate.bsky.social · 10/06/2026
⏰ Missed the deadline? We've got you covered! Registration for the #RepliFate Final Conference has been extended until 15 June 2026. - 6 & 7 July | Helmholtz Munich - Outstanding speaker lineup & 12 MSCA fellows Register now: replifate.eu/event/meetin...
replifate.eu
Events for June 2026
06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...
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Phuc Vo @homyphucvo.bsky.social · 28/05/2026
There's also a chance for YOU to share your science. 🔬 Registration closes 5 June 2026. 👉 Details + registration link: replifate.eu/event/meetin... #DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate
replifate.eu
Events for May 2026
06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...
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Duxin lab @duxinlab.bsky.social · 29/04/2026
Highlights from the Egmond DNA Repair meeting: Julien shared our work, Sidak and Stella brought nice posters—and both got invited to give short talks. And the cherry on top? Stella won the Best Poster Prize, congrats! A pretty great week for the lab 🏆
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ME Torres-Padilla @metorrespadilla.bsky.social · 09/02/2026
We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...
replifate.eu
Events for February 2026
06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...
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Replifate Consortium @replifate.bsky.social · 27/01/2026
'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social), revisits lesion bypass in light of recent advances DOI: 10.1016/j.tibs.2025.07.004
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Duxin lab @duxinlab.bsky.social · 22/01/2026
Our first bachelor student successfully defended her thesis! An impressive piece of lab work paired with a clear, engaging defence and discussion. Congrats! Many thanks to Panos Galanos (SDU) for serving as external examiner and for the thoughtful evaluation. Welcome to the academic club, Amélie!
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Marta Oliva-Santiago @martaolivasantiago.bsky.social · 16/12/2025
The last EDRA webinar of the year is today at 4 pm with Julian Stingele presenting the role of RNA damage in chemotherapy, followed by Andre Bortolini Silveira on BER and MMR converge, and Nicola Pietro Montaldo on Mitochondrial DNA Repair and Parkinson's Disease @edra-webinars.bsky.social
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Duxin lab @duxinlab.bsky.social · 21/11/2025
Don’t miss it! The 12th Conference on Responses to DNA Damage will take place in Egmond aan Zee from 19–24 April 2026. 📅 Registration is open! Deadline for abstracts: Jan 10, 2026. More details & provisional program here: dnarepairmeeting-egmond2026.com
dnarepairmeeting-egmond2026.com
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Duxin lab @duxinlab.bsky.social · 20/11/2025
Fascinating paper from Krietenstein, Groth & Lukas groups showing how cells can repair a DSB, but its 'echo' can persist leading to postrepair chromatin fatigue
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Duxin lab @duxinlab.bsky.social · 03/10/2025
Excited to have contributed to this new @cp-molcell.bsky.social paper on how PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed. A big congrats to Jonas for driving this work forward, great to see the results out! 👉 10.1016/j.molcel.2025.09.006
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Duxin lab @duxinlab.bsky.social · 02/10/2025
BRIC Day with the theme collide across each other — all about sparking new intra-institute collaborations. Kickoff with a keynote from Rasmus Rabøl (Klifo) and a buzzing poster session full of science-in-the-making! @bric-ucph.bsky.social
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Duxin lab @duxinlab.bsky.social · 18/09/2025
Today we swapped pipettes for putters. Day 2 retreat highlight: realizing that hitting the fairway is way harder than hitting a replication fork 😅
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Duxin lab @duxinlab.bsky.social · 17/09/2025
Off to Nord Sjælland with the Miller lab @tcr-miller.bsky.social for our joint retreat! Exciting brainstorming, bonding, and a little hygge ahead. First challenge: design your next @natureportfolio.nature.com article 🚀
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Marta Oliva-Santiago @martaolivasantiago.bsky.social · 08/09/2025
What makes #cshldnarep special isn’t just the cutting-edge, top-notch science; it’s the chance to meet the authors of the papers we build on every day, exchange ideas, and feel part of this community. Heading home exhausted, grateful, full of ideas and renewed motivation to push my project forward!
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Duxin lab @duxinlab.bsky.social · 05/09/2025
Our PhD student @martaolivasantiago.bsky.social and postdoc @amitash.bsky.social presented their posters on #cshldnarep, turning data into an insightful dialogue. Huge thanks to everyone who stopped by our poster!
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Duxin lab @duxinlab.bsky.social · 04/09/2025
This week we’re at CSHL #cshldnarep where the DNA replication & genome maintenance community has gathered for a week of science, discussions, and late-night brainstorming.
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Marta Oliva-Santiago @martaolivasantiago.bsky.social · 25/08/2025
Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @cp-trendsbiochem.bsky.social: “Just bypass it: mechanisms of DNA damage tolerance” 🔗 doi.org/10.1016/j.ti...
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Replifate Consortium @replifate.bsky.social · 22/08/2025
New cool research alert! Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA. Read the full study: doi.org/10.1038/s414...
doi.org
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications
DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...
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Duxin lab @duxinlab.bsky.social · 22/08/2025
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...
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Replifate Consortium @replifate.bsky.social · 03/07/2025
Just published! Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication VCP/p97 = checkpoint gatekeeper! Read the full study: doi.org/10.1038/s414...
doi.org
DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication - Nature Communications
The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing exces...
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Duxin lab @duxinlab.bsky.social · 23/06/2025
🎉 Congratulations to SUND's new professors! The Faculty of Health and Medical Sciences, @ucph.bsky.social celebrated 23 newly appointed professors. Through their dedicated work, they contribute every day to the development of the university, the healthcare system, and society at large.
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Duxin lab @duxinlab.bsky.social · 12/06/2025
🌿 Off to Hillerød for the 2025 MoMeD Summer School! Our PI Julien Duxin -as head of the MoMeD PhD Programme at @ucph.bsky.social- joins our PhD students and many others for 2 packed days of science, networking, and inspiration. Looking forward to connecting and exchanging ideas across fields!
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Replifate Consortium @replifate.bsky.social · 05/06/2025
Frogs in the lab? Yep! 🐸 This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.
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Duxin lab @duxinlab.bsky.social · 04/06/2025
Our lab’s a little more crowded (and a lot more curious) this week! 🧠🐸 We’re thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts. They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.
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Duxin lab @duxinlab.bsky.social · 03/06/2025
🎯 A tenure-track group leader position in translational cancer research is now open at Finsen Laboratory. Come join an excellent and friendly research environment combining both the Rigshospitalet and the KU @ucph.bsky.social affiliated groups candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net
Tenure-track Research Group leader position in translational cancer research at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital
A group leader position at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital is open for appointment as soon as possible. The position is av
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Duxin lab @duxinlab.bsky.social · 27/05/2025
Chromosome Biology Club is back today! Join us for two exciting talks: 🧬 Christian Nielsen (CCS/ICMM) on the distinct roles of condensins I & II in mitotic chromosome mechanics 🧬 Judit Pilmark (BRIC) on mutational signatures linked to NER deficiency Starting at 4.45 pm Followed by pizzas and beer
#CBC
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Leicester Institute for Structural and Chemical Biology @leicstructbio.bsky.social · 13/05/2025
Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ @natcomms.nature.com BRCT domain in recruitment and activity of two Pol X members in NHEJ: a unified model for the interaction of Pol X with Ku70/80. www.nature.com/articles/s41...
nature.com
Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ - Nature Communications
The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range compl...
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EMBO @embo.org · 30/04/2025
The FEBS | EMBO Women in Science Award aims to highlight the major contributions made by female scientists to #LifeSciences research. Winners of the award are inspiring role models for future generations of #WomenInScience Nominate a scientist by 15 May: www.embo.org/the-embo-com... 🧪
embo.org
FEBS|EMBO Women in Science Awardees – Nominate for the Women in Science Award – EMBO
Nominees should be female scientists working in an EMBC Member State or FEBS member country, who have made outstanding contributions to life sciences research and significantly advanced our…
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JStark lab @jstarklab.bsky.social · 12/05/2025
New preprint from the lab @kaelamakins.bsky.social Genetic interactions between 53BP1-RIF1 and DNA-PKcs for DSB repair outcomes. www.biorxiv.org/content/10.1...
biorxiv.org
53BP1/RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.
DNA double strand breaks (DSBs) are the effective lesion of cancer radiotherapy and induce gene editing. 53BP1 accumulates at DSBs and is implicated in end joining (EJ) repair, but its influence on DS...
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Alessandra Brambati @alebrambati.bsky.social · 12/05/2025
Our study highlights RNA as a direct template for DNA repair, revealing RT-DSBR as a previously unrecognized and potentially mutagenic pathway. Huge thanks to the incredible team who made this work possible! (5/5) 🔗 www.nature.com/articles/s41... #GenomeInstability #DNARepair #RNA #CRISPR #DSB
nature.com
RNA transcripts serve as a template for double-strand break repair in human cells - Nature Communications
DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repai...
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Emilio Lecona @emlecona.bsky.social · 08/05/2025
Today we celebrated #EuropeDay2025 showing the work we do at the RepliFate Doctoral Network in the public library Eugenio Trías @cbm-csic-uam.bsky.social @genomefun.bsky.social
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Andrew Deans @genomestability.bsky.social · 29/04/2025
🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks www.pnas.org/doi/abs/10.1...
pnas.org
ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restart | PNAS
The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserv...
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Duxin lab @duxinlab.bsky.social · 24/04/2025
🌍 #ClimateActionDay is here! For the first time, the University of Copenhagen @ucph.bsky.social is joining forces to take real steps toward a greener future At BRIC @bric-ucph.bsky.social, we’re putting words into action! Small changes can make a big impact 🌱 #GreenLabs #SustainableScience
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Duxin lab @duxinlab.bsky.social · 24/04/2025
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Barbara Marte @barbmarte.bsky.social · 15/04/2025
this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.
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Luijsterburglab @luijsterburglab.bsky.social · 09/04/2025
A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com
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Duxin lab @duxinlab.bsky.social · 18/04/2025
We had the pleasure of hosting Prof. Andrew Jackson from the University of Edinburgh, who gave a brilliant and thought-provoking talk on how single-gene mutations can lead to microcephaly—bridging genome integrity and stem cell biology. Looking forward to potential synergies between our labs!
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Duxin lab @duxinlab.bsky.social · 04/04/2025
#WomenInScience KU @ucph.bsky.social is marking 150 years since women were first allowed to study at the university! Nielsine Nielsen was Denmark’s first female doctor, marking a major milestone in the path toward gender equality. The full program of events and celebrations here: kvinder150.ku.dk
kvinder150.ku.dk
150-året for kvinders adgang til Københavns Universitet – Københavns Universitet
Med fejringen af 150-året kaster Københavns Universitet lys over, hvordan det gik til, da kvinder fik adgang til universitetet, og hvad det kom til at betyde både for kvinder, universitetet og…
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Hana Polasek-Sedlackova @hanasedlackova.bsky.social · 30/03/2025
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
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Replifate Consortium @replifate.bsky.social · 28/03/2025
It’s time for new duo: Julius Thomas & his PI Lorenza Penengo from the University of Zurich. They study the ISG15 system in DNA replication—but there’s more! One could be found scaling alpine peaks, while the other might just trade the lab for the thrill of mushroom hunting. Curious to know more? 🍄
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Duxin lab @duxinlab.bsky.social · 25/03/2025
🚨#CBC is happening today! Don’t forget—our next Chromosome Biology Club is today at 16:45 at the Biocenter! Three great speakers and exciting science await, followed by beer and pizza. See you there!
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Pagès lab @pageslab.bsky.social · 24/03/2025
Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/...
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Kumar Somyajit & Lab @ksomyajit.bsky.social · 20/03/2025
Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading. www.biorxiv.org/content/10.1... Brief teaser:
biorxiv.org
PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity
Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting r...
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SFB1361 @sfb1361.bsky.social · 17/03/2025
Pre-print alert from @hopfnerlab.bsky.social! Great job! Read more about it here: www.biorxiv.org/content/10.1... #DNArepair #SFB1361
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Duxin lab @duxinlab.bsky.social · 19/03/2025
📅 Our next Chromosome Biology Club is next week! Join us on March 25th at the Biocenter for exciting talks from: ◉ Johanna Kliche (Nilsson group, @nilssonlab.bsky.social) ◉ Oline Pade Jensen (Lisby group) ◉ Luke Greenhough (Steve West group, @xrnchew.bsky.social) Mark your calendars! #CBC
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Duxin lab @duxinlab.bsky.social · 17/03/2025
📅 The Evil Within: Regulation and Repair of Endogenous DNA Damage conference is coming to @imbmainz.bsky.social, Germany on March 10–13, 2026. Registration opens late summer 2025! Follow @sfb1361.bsky.social for updates. #ISC26DNArepair #DNARepair #DNADamage
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Replifate Consortium @replifate.bsky.social · 25/02/2025
We’re kicking off our RepliFate introductions with @Phuc and her PI, @sylvie-noordermeer.bsky.social ! As part of the RepliFate network, they are contributing to exciting research in double-strand break (DSB) repair. Wanna know more about their work, hobbies, and fun facts? Check out their profiles!
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Duxin lab @duxinlab.bsky.social · 03/03/2025
We'll be hosting Peter Martin (Niedzwiedz Lab, ICR London) tomorrow to discuss his recently baked preprint: "The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ" (buff.ly/4hYnS2u). Thanks for accepting our invitation, we're looking forward to this JC!
buff.ly
The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ
Mitotic DNA double-strand breaks (DSBs) accumulate in response to replication stress or BRCA1/2 deficiency posing a significant threat to genome stability as repair by non-homologous end-joining…
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Duxin lab @duxinlab.bsky.social · 20/02/2025
This week we had the pleasure of hosting Pei-Ying Lin in our lab as part of the @replifate.bsky.social Artists in Residency program. Together with Pei, we explored how scientific discovery can fuel creativity and new perspectives #SciArt 🧠🧶🎨
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