Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itse...

The 2026 Gordon Research Conference on DNA Damage, Mutation and Cancer will be held in Ventura, California. Apply today to reserve your spot.

Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...

The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. Th...

This year, six doctoral graduates and two habilitation graduates are receiving awards from the Munich University Association.

Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less n...

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Pflichtfelder sind mit einem (*) markiert.

Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...

As an Editor of the journal Development, I often hear complaints about peer review. We all know the problems - from lengthy review times to requests for seemingly unnecessary experiments. I agree with many of these complaints. Katherine Brown (Executive Editor of Development) and I recently wrote an editorial about this in which we talk about some of the things Development is doing to mitigate the worst of the problems.

Epigenetic inheritance can be influenced by environmental conditions and somatic inputs originating from different tissues. Such transgenerational inheritance is reversable as it does not lead to muta...

Dreyer et al. show the broad and rapid impact that acute inhibition of chromatin formation in S-phase has on DNA replication, chromatin stability, and cell-cycle progression. This study sheds light on...

Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1 and FANCM. Their combined loss leads to catastrophic genome instability, particularly at simple-repeat sequence...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution