Baby KJ was a pioneer before he was even a year old. Born in 2024 with a rare, life-threatening genetic mutation, Nicole and Kyle Muldoon’s son is the world’s first patient to receive successful personalized gene editing therapy. Doctors at the Children’s Hospital of Philadelphia and Penn Medicine collaborated to create a unique drug just for KJ, to treat his disorder. Now, a busy toddler and youngest brother, KJ is a piece of medical history and he just started to walk.

In this episode, Andrew Cohen, DMD, who is board certified in dental sleep medicine and a comprehensive restorative dentist, explains how anatomy, behavior, and overall health impacts sleep-related breathing. We discuss common issues like mouth-breathing, teeth grinding, thumb-sucking, and extended pacifier use and how these impact dental health and sleep. For more information, visit the CHOP Sleep Center.   Opinions expressed in this episode are those of Andrew Cohen, DMD, and not necessarily representative of Children's Hospital of Philadelphia.

Craniosynostosis (CS) is a congenital condition characterized by the premature fusion of cranial sutures due to abnormal developmental pathways (Governale et al., 2015). This fusion can lead to increased intracranial pressure, cognitive impairment, and visible skull deformities. Current treatments include helmet therapy and minimally invasive surgical procedures. However, re-craniosynostosis can occur, limiting the long-term effectiveness of surgery. In addition, these procedures are associated with significant financial costs and carry risks such as substantial blood loss. Through the Princeton IIP program, I had the opportunity to research sustainable alternatives for CS treatment.

Daniel P. Kelly, MD, CHOP's Cardiovascular Institute Director, won AHA's 2025 Distinguished Scientist Award for cardiovascular research. Children’s Hospital of Philadelphia (CHOP) is pleased to announce that Daniel P. Kelly, MD, Director of the Cardiovascular Institutes at CHOP and the Perelman School of Medicine at the University of Pennsylvania and a renowned researcher in the field of cardiovascular and metabolic diseases, was presented with the prestigious 2025 Distinguished Scientist Award by the American Heart Association (AHA) at the organization’s Scientific Sessions in New Orleans on Saturday, November 8th. The AHA’s Distinguished Scientist award, established in 2003, celebrates members who have made extraordinary contributions to research in cardiovascular, stroke, and brain health.“I am deeply honored to receive the 2025 Distinguished Scientist award," said Kelly. “Support from the AHA was crucial in launching my research, allowing me to make meaningful contributions to pediatric heart health by fostering connections with fellow scientists and collaborators.”Kelly's research journey began with a focus on rare genetic metabolic disorders that lead to cardiomyopathy and sudden death in children. This evolved into a broader mission to uncover the metabolic roots of heart disease. Among his groundbreaking work, Kelly identified genetic causes affecting mitochondrial fat metabolism, which led to practical newborn screening tests.His research has transitioned from fundamental discoveries to developing new therapies that address metabolic imbalances in heart failure. One of these therapies progressed to human clinical trials, marking a significant milestone in potential heart disease treatments.Kelly has received numerous accolades throughout his career. He is a member of the American Society for Clinical Investigation and the Association of American Physicians, where he served as President in 2022. His previous honors from the AHA include the 1995 Established Investigator Award, the 2008 Basic Cardiovascular Science Council Distinguished Achievement Award, and the 2009 Basic Research Prize.

Podcast Episode · Primary Care Perspectives · 10/28/2025 · 32m

Podcast Episode · Primary Care Perspectives · 10/08/2025 · 29m

Children's Hospital of Philadelphia, 4th Annual CHOP Lymphatic Disorder Conference, 9/18/2025 8:00:00 AM - 9/19/2025 4:00:00 PM, Join us at the Lymphatic System Learning Conference, where healthcare professionals from various disciplines gather to deepen their understanding of the body's often overlooked but crucial lymphatic system. Through engaging presentations, interactive workshops, and collaborative discussions, participants will explore the anatomy, physiology, disorders, and treatment modalities related to the lymphatic system. From cutting-edge research to practical hands-on techniques, attendees will gain valuable insights and skills to enhance patient care and improve outcomes. Don't miss this opportunity to connect with experts, expand your knowledge, and advance your practice in lymphatic health.

The Cardiac Center at the Children’s Hospital of Philadelphia (CHOP) is leading pioneering research with grants aimed at improving outcomes for children with severe cardiac conditions. These efforts represent a comprehensive approach to advancing cardiac care from prenatal stages through childhood, potentially transforming treatment paradigms.

Researchers at Children's Hospital of Philadelphia (CHOP) are shedding light on how two genetic factors - an extra copy of chromosome 21 (trisomy 21) and mutations in the GATA1 gene - interact to derail early blood cell development.

An estimated 11.4% of US children are diagnosed with ADHD. In this episode, Thomas Power, PhD, ABPP, Director of the Center for Management of ADHD at CHOP, discusses a new Clinical Pathway for the Evaluation and Treatment of ADHD and how primary care providers can utilize and promote psychosocial interventions for ADHD. We discuss behavioral parent training, peer interventions, school supports, emotion regulation, and more, in this fascinating episode!