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Sadaf Shadan

@sshadan.bsky.social
326 followers 152 following 50 posts

Senior Editor @Nature handling manuscripts in general cell biology and plant biology. Views expressed here are my own.

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Sadaf Shadan @sshadan.bsky.social · 16/09/2026
Ferroptotic cell death is linked to many diseases. Work @nature shows that coordinated mitochondrial and peroxisomal fragmentation boosts oxidative stress and accelerates ferroptosis. The authors also report a live-cell biosensor to track and manipulate this process. shorturl.at/CrjEy
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Mitochondrial fission factor senses and governs ferroptosis - Nature
The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables high-content screening of ferroptosis-sensitizing compounds and the discovery of upstream regulators of MFF.
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Sadaf Shadan @sshadan.bsky.social · 16/09/2026
Plants use the hormone salicylic acid (SA) to fight infection, but how it activates gene expression remained unclear. Two studies @nature show that the mechanism involves interaction between SA receptor NPR1 and a component of the transcriptional machinery. shorturl.at/7PymL & shorturl.at/Iy4oY
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Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors - Nature
Nature - Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors
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Sadaf Shadan @sshadan.bsky.social · 14/08/2026
The forgotten 20 million: why is the world neglecting Afghanistan’s girls and women? www.nature.com/articles/d41...
nature.com
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Sadaf Shadan @sshadan.bsky.social · 21/07/2026
Heat stress can make plasma membranes (PMs) too fluid. Work @nature shows how rice cells rapidly flip saturated phosphatidylcholine across the PM, stabilizing membrane fluidity, limiting ion leakage, and promoting heat tolerance and yield stability. shorturl.at/PZFg4 &NV shorturl.at/kU4Uv
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Plant membranes shuffle lipids around to stay firm under heat stress
High temperatures make cell membranes weak and leaky. Rice plants rapidly counteract this effect by adjusting membrane lipid content, enabling them to resist heatwaves.
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Sadaf Shadan @sshadan.bsky.social · 01/07/2026
Nature Communications is looking for a plant biology editor: springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com
Associate/ Senior Editor
Job Title: Associate or Senior Editor Locations: Pune, Shanghai, Beijing Application Deadline: 15th July'26 About Springer Nature Springer Nature is one of the leading publishers of research in the wo...
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Sadaf Shadan @sshadan.bsky.social · 17/06/2026
Cold weather and high fertilizer use threaten rice yields. @nature, authors identify a gene, CHPO, that helps rice recover after chilling and use nitrogen more effectively. Natural variation in CHPO can be used to grow rice better in cold conditions with less fertilizer. shorturl.at/eLUjv
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Sadaf Shadan @sshadan.bsky.social · 12/06/2026
Plants use nitrogen inefficiently. A study @nature shows that, in maize, the plastoglobule droplets within chloroplast organise key nitrogen-fixation enzymes, supercharging nitrogen use. The findings could be relevant to growing crops using less fertiliser. shorturl.at/1dNA9 &NV shorturl.at/G1NDu
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Plastoglobules compartmentalize nitrogen assimilation in maize - Nature
Chloroplast plastoglobules act as nitrogen-assimilation hubs in maize, with key enzymes enhancing nitrogen-use efficiency and offering new strategies for developing high-yield, sustainable crops.
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Sadaf Shadan @sshadan.bsky.social · 03/06/2026
Cold weather damages crops by causing pollen to fail. Work @nature shows how plants detect and respond to cold during pollen development. It uncovers a peptide receptor signalling pathway that boosts pollen cold resilience, restoring ~52% of tomato yield and ~18% in rice. shorturl.at/j7zOb
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Cold-induced peptide signalling secures pollen resilience and crop yield - Nature
A small-peptide signalling axis involving RGF family members controls resilience to cold stress in tomatoes and rice; modulating this pathway prevents cold-induced yield losses.
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Sadaf Shadan @sshadan.bsky.social · 03/06/2026
The ESCRT machinery mediates repair of damaged lysosomal membranes. But how does it recognise damage? Authors @nature report LASER, a fast-forming protein assembly that detects Ca2+-leakage from sites of lysosomal injury and recruits ESCRTs there. shorturl.at/T9zM6
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LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
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Sadaf Shadan @sshadan.bsky.social · 03/06/2026
Unlike its wild ancestor teosinte, maize lost much of its seed protein during domestication. A paper @nature discovers teosinte genes that, when expressed in modern maize, increase seed protein without lowering crop yield. shorturl.at/zdsvY & highlight @natplants.nature.com: shorturl.at/e3f6C
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Teosinte alleles enhance nitrogen assimilation and seed protein in maize - Nature
Teosinte alleles enhance nitrogen assimilation and seed protein without lowering crop yield when expressed in modern maize, providing a powerful strategy for crop improvement to meet future population demands.
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Sadaf Shadan @sshadan.bsky.social · 28/05/2026
Water is essential to life; so how do cells sense and respond to the stress associated with changes in water levels? Work @nature shows that when water is scarce, the plant protein SAM8 forms condensates, trapping RNA-processing factors and so reprogramming translation. shorturl.at/4VZQf
nature.com
Cellular water-potential sensing through biomolecular condensation - Nature
Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering RNA export and gene translation.
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Sadaf Shadan @sshadan.bsky.social · 21/05/2026
@nature, researchers describe an RNA-RNA-mediated arm-race between fungal pathogens and their plant hosts. Specifically, they show that a fungal lncRNA weakens host immunity by sequestering a protective rice miRNA. shorturl.at/mIuvy
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A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence - Nature
A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.
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Sadaf Shadan @sshadan.bsky.social · 22/04/2026
Work @nature reports a technique that reveals that ubiquitin tags not just proteins and lipids but also sugars and other small molecules. Focusing on glycogen, the authors show its ubiquitination in cells and tissues, and in the context of metabolism and disease. www.nature.com/articles/s41...
nature.com
Ubiquitination of glycogen and metabolites in cells and tissues - Nature
Nature - Ubiquitination of glycogen and metabolites in cells and tissues
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Sadaf Shadan @sshadan.bsky.social · 22/04/2026
Just as low-oxygen levels stress plants that are exposed to flooding, so does post-flooding reoxygenation and the associated burst of reactive oxygen species. Work @nature, shows that in both cases, the same molecular players mediate plants’ stress response. shorturl.at/kIRDf
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H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses - Nature
Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergence-induced hypoxia and reoxygenation upon desubmergence.
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Sadaf Shadan @sshadan.bsky.social · 09/04/2026
Work @nature shows how an NLR--transcription factor module mediates rice resistance to bacterial blight. Rice subspecies differing in this module vary in pathogen resistance. The authors overcome lower resistance by manipulating the two layers of plant immunity. share.google/yeQzT8TgUzaM...
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Sadaf Shadan @sshadan.bsky.social · 02/04/2026
Numerous fungal diseases threaten rice crops. @nature, researchers identify a gene that makes rice susceptible to multiple fungal pathogens. In field-based experiments, rice crops in which this gene was disrupted showed resistance to several fungal diseases. www.nature.com/articles/s41...
nature.com
Inactivating SnRK1β1A promotes broad-spectrum disease resistance in rice - Nature
SnRK1β1A in rice promotes susceptibility to multiple fungal diseases, and disrupting this infection-inducible gene confers broad-spectrum resistance without compromising growth or yield under normal f...
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Sadaf Shadan @sshadan.bsky.social · 11/03/2026
To activate plant immunity, NLR receptors such as SUMM2 form resistosome complexes, which act as Ca2+-permeable plasma-membrane channels. Work @nature shows how SUMM2 and its associates assemble into even higher-order clusters to initiate cell death. shorturl.at/653TZ plus N&V shorturl.at/vqqYg
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Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR - Nature
SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.
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Sadaf Shadan @sshadan.bsky.social · 25/02/2026
@Nature: an E3 ligase, acting via the jasmonate pathway, is a common regulator of both cold stress & phosphate uptake. Guided by AI, the authors use genome editing to show the relevance of this finding for improving maize yield in multi-site field trials. shorturl.at/KrKBo & NV shorturl.at/rwldu
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Rewiring an E3 ligase enhances cold resilience and phosphate use in maize - Nature
The E3 ubiquitin ligase NLA postively regulates cold tolerance and negatively regulates phosphate uptake in maize, and a genetically engineered variant of this enzyme leads to improved cold ...
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Sadaf Shadan @sshadan.bsky.social · 13/01/2026
Lipid transfer proteins (LTPs) maintain the specific lipid compositions of cellular membranes. @nature, a systematic characterization of complexes between human LTPs and their lipid cargo provides a resource for a better understanding of these proteins. www.nature.com/articles/s41...
nature.com
Client Challenge
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Sadaf Shadan @sshadan.bsky.social · 06/01/2026
The journal Nature is looking for a Metabolism and Cardiovascular biology editor -- deadline coming soon. springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com
Associate or Senior Editor, Nature Biological, Clinical, and Social Sciences
Title: Associate or Senior Editor, Nature Biological, Clinical, and Social Sciences Organization: Nature Portfolio Locations: New York, Jersey City, or Berlin – Hybrid Working Model Closing Date: Janu...
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Sadaf Shadan @sshadan.bsky.social · 10/12/2025
Disruption of protein import into mitochondria affects cellular balance and can cause disease. Work @nature shows that cells sense this defect through inter-organelle communication and a signalling role of mitochondrial targeting sequence. www.nature.com/articles/s41...
nature.com
A direct role for a mitochondrial targeting sequence in signalling stress - Nature
Cells can sense mitochondrial damage through signalling via an unimported mitochondrial targeting sequence.
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Sadaf Shadan @sshadan.bsky.social · 27/11/2025
One environmental factor that affects crop yield is soil stress. Work @nature shows how soil compaction stress affects plant root growth through hormonal signals and cell-wall remodelling. www.nature.com/articles/s41...
nature.com
Ethylene modulates cell wall mechanics for root responses to compaction - Nature
Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root ra...
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Sadaf Shadan @sshadan.bsky.social · 10/11/2025
On plant cells, receptor-like kinases mediate both immune and symbiotic signalling. Work @nature provides amino-acid-level molecular insights into how signalling specificity is achieved downstream of such similar receptors. www.nature.com/articles/s41...
nature.com
Two residues reprogram immunity receptors for nitrogen-fixing symbiosis - Nature
An investigation of plant receptor-like kinases identifies regions of these proteins that control whether immune or symbiotic signalling pathways are activated, with minimal changes to specific r...
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Sadaf Shadan @sshadan.bsky.social · 21/08/2025
The >1000 lipid species found in eukaryotic cells have vital functions. Using a combination of microscopy, spectroscopy and modelling, authors report @nature the first quantitative map of retrograde flux of individual lipids in cells.
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Sadaf Shadan @sshadan.bsky.social · 24/07/2025
An @nature paper presents a single-cell multi-omics atlas of eight rice organs. Insights emerging from this resource include new cell states during rice development and correlations between cell type and agronomic traits. www.nature.com/articles/s41...
nature.com
A single-cell multi-omics atlas of rice - Nature
A single-cell multi-omics atlas of rice is revealed, providing insight into cell-type functions and molecular programs.
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Sadaf Shadan @sshadan.bsky.social · 24/07/2025
In today’s issue of @nature, read a Review article on the latest and upcoming technologies that could aid research and development in crop science, contributing to sustainable global food security. www.nature.com/articles/s41...
nature.com
Integrated biotechnological and AI innovations for crop improvement - Nature
The integration of omics technologies, genome editing and protein design with artificial intelligence (AI) promises rapid advances in the field of crop improvement that will improve global food securi...
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Sadaf Shadan @sshadan.bsky.social · 24/07/2025
Plant NLR receptors mediate pathogen resistance, and so their engineering could lead to crops with broader pathogen specificity and so broader disease resistance. @nature, authors report one such attempt achieving resistance to several potyviruses. www.nature.com/articles/s41... & shorturl.at/932j7
nature.com
Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature
Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.
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Sadaf Shadan @sshadan.bsky.social · 24/07/2025
How the plant defence hormone salicylic acid (SA) is formed in some bacteria and in Arabidopsis is well-established. Three @nature papers now describe a different pathway of SA biosynthesis in non-Brassicaceae plants. rb.gy/9tgn8g shorturl.at/fYAYo shorturl.at/UCvo0 & NV tinyurl.com/bdz2p6dx
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Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants - Nature
The salicylic acid (SA) biosynthesis pathway—involving ligation of benzoyl coenzyme A and benzyl alcohol to give benzyl benzoate; hydroxylation of benzyl benzoate to give benzyl salicylate; and cleava...
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Sadaf Shadan @sshadan.bsky.social · 13/07/2025
Very much looking forward to hearing and seeing exciting research and to interacting with reseachers at #2025ISMPMI. Happy also to answer any questions about publishing in Nature and sister journals.
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Sadaf Shadan @sshadan.bsky.social · 02/07/2025
How do plants notice loss of structural barriers (e.g. the periderm, which prevents water loss and pathogen infection) to regenerate them? Work @nature shows that plants sense damage to barrier integrity from diffusion of gases such as ethylene and oxygen. shorturl.at/FIhJ8 & N&V shorturl.at/u7PYs
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Injured plants use gaseous cues to initiate repair of their outer layers
The periderm layers of plants form an outer protective barrier. If the periderm is broken, movement of the gases ethylene and oxygen triggers a healing process.
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Sadaf Shadan @sshadan.bsky.social · 16/06/2025
www.nature.com/articles/d41...
nature.com
Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
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Sadaf Shadan @sshadan.bsky.social · 05/06/2025
A bottleneck for studying the biological function of biomolecular condensates is unavailability of tools to selectively probe them within living cells. @nature, researchers report one such tool, showcasing its use in various contexts including disease. www.nature.com/articles/s41...
nature.com
Probing condensate microenvironments with a micropeptide killswitch - Nature
Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells
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Sadaf Shadan @sshadan.bsky.social · 28/05/2025
The diverse cellular roles of early endosomes involve coordinated activity of several hundred integral membrane proteins and transiently associated regulatory complexes. A study @nature presents a systematic structural interactome of human endosomes . www.nature.com/articles/s41...
nature.com
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
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Sadaf Shadan @sshadan.bsky.social · 28/05/2025
Want a taster of working as an editor? Nature has a locum position open for someone with interest in stem cell biology, developmental biology, and/or specific aspects of general cell biology. springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com
Locum Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences)
Job title: Locum Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences) Location: New York or Berlin (Hybrid working pattern) Deadline: June 11th , 2025 About Springer Nature G...
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Sadaf Shadan @sshadan.bsky.social · 15/05/2025
www.nature.com/articles/d41...
nature.com
Nature project to encourage early-career researchers in peer review is working
Science stands to benefit from a project in which experienced academics and early-career researchers co-review studies.
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Sadaf Shadan @sshadan.bsky.social · 06/05/2025
Legume can form symbiotic relationship with some bacteria, while recognising others as pathogens. Work @nature identifies a plant kinase that mediates this nuanced balance of tolerance towards symbionts without compromised plant immunity. www.nature.com/articles/s41...
nature.com
A kinase mediator of rhizobial symbiosis and immunity in Medicago - Nature
Nature - A kinase mediator of rhizobial symbiosis and immunity in Medicago
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Sadaf Shadan @sshadan.bsky.social · 06/05/2025
The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...
nature.com
Molecular basis of SIFI activity in the integrated stress response - Nature
Nature - Molecular basis of SIFI activity in the integrated stress response
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Sadaf Shadan @sshadan.bsky.social · 30/04/2025
Plant roots adapt to their environment including to soil conditions. Using single-cell transcriptomics, @nature authors report on the rice root responses and adaptations to soil-related stresses at individual cell level. www.nature.com/articles/s41...
nature.com
Single-cell transcriptomics reveal how root tissues adapt to soil stress - Nature
Single-cell RNA sequencing and spatial transcriptomic approaches reveal major expression changes in outer root cell types when grown in soil versus gel conditions, and also uncover how root tissu...
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Sadaf Shadan @sshadan.bsky.social · 23/04/2025
At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids. shorturl.at/lycuz & shorturl.at/ARpUK
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Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
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Sadaf Shadan @sshadan.bsky.social · 08/04/2025
The technique of haploid induction creates homozygous plants, enabling faster breeding cycles. A paper @nature discovers a way of generating haploid sunflower, and optimises the approach for efficiency compatible with breeding programs for this important oilseed crop. rb.gy/vrqana & N&V rb.gy/e7uyep
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Haploid facultative parthenogenesis in sunflower sexual reproduction - Nature
Spontaneous parthenogenesis in sunflower has been used to develop a scalable doubled haploid breeding system.
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Sadaf Shadan @sshadan.bsky.social · 19/03/2025
Proteins and nucleic acids move in and out of the nucleus through nuclear pore complexes (NPCs). Using 3D MINFLUX, @nature authors study single import and export events, gaining detailed insights into transport across NPCs within cells and at nanometer and millisecond scales. shorturl.at/2ClQp
nature.com
Overlapping nuclear import and export paths unveiled by two-colour MINFLUX - Nature
High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the nuclear pore ...
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Sadaf Shadan @sshadan.bsky.social · 12/03/2025
Vector-borne viral pathogens are threats to crops, and so trigger plant immune responses. Studying rice, authors @nature provide molecular-level insights into the first steps of plant antiviral response. www.nature.com/articles/s41...
nature.com
Perception of viral infections and initiation of antiviral defence in rice - Nature
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.
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Sadaf Shadan @sshadan.bsky.social · 05/03/2025
While work @nature recently showed that the TIR1/AFB receptors of the plant hormone auxin have adenylate cyclase activity, further work now shows the broad physiological significance of this activity during plant development, via transcriptional reprogramming. www.nature.com/articles/s41...
nature.com
TIR1-produced cAMP as a second messenger in transcriptional auxin signalling - Nature
cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling.
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Sadaf Shadan @sshadan.bsky.social · 25/02/2025
@nature, an extensive study, involving 18 KO and mutant mouse models, reveals why Parkin KO mice grow normally. It finds that the Parkin-mediated mitochondrial quality control works alongside another such pathway, involving Oma1. www.nature.com/articles/s41...
nature.com
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature
We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...
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Sadaf Shadan @sshadan.bsky.social · 12/02/2025
In plant immunity, activated sensor NLRs generate second messengers, which in turn activate helper NLRs such as NRG1. Two studies @nature use cryo-EM to provide mechanistic insights into NRG1 activation and inhibition. www.nature.com/articles/s41... & www.nature.com/articles/s41...
nature.com
Balanced plant helper NLR activation by a modified host protein complex - Nature
In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and...
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Sadaf Shadan @sshadan.bsky.social · 30/01/2025
Initiation of symbiosis between legumes and nitrogen-fixing microorganisms involves Ca2+ oscillations in root cells. Work @nature provides insights into molecular fine-tuning of the Ca2+ oscillations, and show the transfer of this beneficial trait to wheat. www.nature.com/articles/s41...
nature.com
Autoactive CNGC15 enhances root endosymbiosis in legume and wheat - Nature
Nuclear calcium oscillations initiate plant–arbuscular mycorrhiza and nitrogen-fixing bacteria symbioses for nutrient acquisition, with a newly discovered autoactive CNGC15 mutant enhancing ...
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Sadaf Shadan @sshadan.bsky.social · 29/01/2025
How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR & NV shorturl.at/fImjA
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C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
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Sadaf Shadan @sshadan.bsky.social · 29/01/2025
Crops face a variety of challenging conditions, including alkaline soil and global warming. @nature, scientists gain molecular insights and apply them to not only make rice both alkali- and temperature-tolerant, but also to further increase its yield. www.nature.com/articles/s41...
nature.com
Fine-tuning gibberellin improves rice alkali–thermal tolerance and yield - Nature
Precise regulation of the phytohormone gibberellin to optimal levels may not only confer alkali–thermal tolerance to Green Revolution rice varieties but may also further enhance their yield, and ...
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Sadaf Shadan @sshadan.bsky.social · 15/01/2025
Increased soil salinity causes crop losses, due to cellular Na+ toxicity. @nature scientists use CryoNanoSIMS for high-res imaging of the subcellular distribution of Na+ and K+ in root cells of Arabidopsis and rice, gaining insights into consequences of salt stress. www.nature.com/articles/s41...
nature.com
Elemental cryo-imaging reveals SOS1-dependent vacuolar sodium accumulation - Nature
This study demonstrates that cryo nanoscale secondary ion mass spectrometry (CryoNanoSIMS) enables direct multi-elemental imaging at subcellular resolution of macro- and micronutrients or trace elemen...
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Sadaf Shadan @sshadan.bsky.social · 11/12/2024
@nature, researchers report on their cryo-ET analysis of human TRiC/CCT -- the ATP-driven chaperonin the dysfunction of which is linked to disease. The work provides mechanistic insights into the functioning of this protein-folding machine within cells. shorturl.at/H69Ye
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In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor - Nature
TRiC functions at near full occupancy to fold newly synthesized proteins inside cells.
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