Ferroptotic cell death is linked to many diseases. Work @nature shows that coordinated mitochondrial and peroxisomal fragmentation boosts oxidative stress and accelerates ferroptosis. The authors also report a live-cell biosensor to track and manipulate this process.
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Mitochondrial fission factor senses and governs ferroptosis - Nature
The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables high-content screening of ferroptosis-sensitizing compounds and the discovery of upstream regulators of MFF.