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Reactome

@reactome.org
811 followers 70 following 130 posts

Reactome is an open source curated pathway database that provides pathway and network analysis tools for life science researchers.

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Reactome @reactome.org · 13/07/2026
Release News: V97 of Reactome is live! 🎉 We have new and updated topics and pathways. Read more here: reactome.org/about/news/2...
reactome.org
V97 Released - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 17/06/2026
Check out our Reactome Research spotlight! A 2026 Nature Genetics study found 13 genetic loci linked to susceptibility to SARS-CoV-2 Omicron infection. Reactome analysis showed these genes are enriched in glycosylation pathways, pointing to host glycan biology as a key factor in viral infectivity
reactome.org
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 17/04/2026
Check out our selection for our latest #ReactomeResearchSpotlight! 💡 In their March 2026 Society of Toxicology paper, “A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets”. 🖥️🧬
reactome.org
A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 07/04/2026
Release News: V96 of #Reactome is live! 🎉 We have new and updated topics and pathways in Developmental biology, Disease, Immune system, Metabolism, Muscle Contraction, and more. 💡 Read more about V96 here :https://reactome.org/about/news/291-v96-released
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Reactome @reactome.org · 19/02/2026
Check out our selection for our latest #ReactomeResearchSpotlight! 💡 🔗 reactome.org/content/reac... 🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight! 🖥️🧬
reactome.org
MarkerPredict: predicting clinically relevant predictive biomarkers with machine learning - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 05/02/2026
Preprint alert! 🚨 We’ve released two new Reactome preprints. Together, these studies show how AI can scale curation and improve accessibility without compromising accuracy or biological rigor. Learn more here: reactome.org/about/news/2... 🖥️🧬
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Reactome @reactome.org · 13/01/2026
Check out our selection for our first 2026 #ReactomeResearchSpotlight! 💡 🔗 reactome.org/content/reac... 🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight! 🖥️🧬
reactome.org
Inhibition of type I interferon signaling is a conserved function of gamma-herpesvirus-encoded microRNAs - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 11/12/2025
Release News: V95 of #Reactome is live! 🎉 We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.
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Reactome @reactome.org · 08/12/2025
New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/... Redesigned Angular interface ReacFoam & entity-level visualizations Multi-omics analysis tools React-to-Me chatbot FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized 🖥️🧬
doi.org
The Reactome Knowledgebase 2026
Abstract. The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes huma
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Reactome @reactome.org · 25/11/2025
Advances like this underline how much early detection and mechanistic clarity matter in rare metabolic disease. For those examining the underlying biology of Hunter syndrome, Reactome’s pathway (reactome.org/content/deta...) provides a clear view of the disrupted iduronate-2-sulfatase process.
reactome.org
Reactome | MPS II - Hunter syndrome (HS-GAG degradation)
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 20/11/2025
This week marks World Antimicrobial Resistance (AMR) Awareness Week. In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here: reactome.org/PathwayBrows...
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Reactome @reactome.org · 21/10/2025
Check out our selection for October's #ReactomeResearchSpotlight! Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response" Read more: 🔗 reactome.org/content/reac... 🖥️🧬
reactome.org
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 10/10/2025
See you all next week!
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Reactome @reactome.org · 10/10/2025
🚨 New Beta Release: Reactome Pathway Browser Explore biology with a modernized interface: 🔗 reactome.org/beta/Pathway... Feedback welcome → forms.gle/TPBxaWnnVLLZ... 🖥️🧬
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Reactome @reactome.org · 07/10/2025
🎉 We just launched the Reactome Figma Library! You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0. www.figma.com/community/fi... Demo video: youtu.be/xl2LfczKhGY 🖥️🧬
figma.com
Reactome Icon Library | Figma
A curated set of biological icons designed to support scientists and designers in creating clear, consistent figures and posters. Includes pathway components such as proteins, complexes, reactions, an...
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Reactome @reactome.org · 18/09/2025
Release News: V94 of #Reactome is live! 🎉 We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules 🖥️🧬
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Reposted by Reactome
Reactome @reactome.org · 30/05/2025
Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome 🖥️🧬 Read more about it here: reactome.org/content/reac...
reactome.org
Reactome Strengthens Accuracy by Monitoring for Retracted Publications - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reposted by Reactome
Reactome @reactome.org · 27/08/2025
Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.
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Reactome @reactome.org · 04/09/2025
Starting the new academic year with a Reactome Research Spotlight🖥️🧬 In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...
Figure 1 of the paper: Training a machine learning framework for predicting cancer cell sensitivity to drugs.
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Reactome @reactome.org · 27/08/2025
Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.
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Reactome @reactome.org · 24/06/2025
Release News: V93 of #Reactome is live! 🎉 We have new and updated topics and pathways. 💡 Read more about V93 here: reactome.org/about/news/2...
reactome.org
Community - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 30/05/2025
Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome 🖥️🧬 Read more about it here: reactome.org/content/reac...
reactome.org
Reactome Strengthens Accuracy by Monitoring for Retracted Publications - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 22/05/2025
Reactome is now CoreTrustSeal certified, meaning that our pathway data meets global standards for transparency, accessibility & long-term stability. Learn more at reactome.org/about/news/2... A big win for #FAIRdata, open science, and everyone who relies on Reactome for biological knowledge. 🖥️🧬
reactome.org
Reactome Recognized with CoreTrustSeal Certification - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 20/05/2025
Check out this recap, where our #Reactome Outreach Coordinator summarizes some of the team discussions we had at #ReactomeSAB 2025! 🖥️🧬
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Reactome @reactome.org · 07/04/2025
Check out our new Youtube video about contributing to Reactome! Learn more by watching our youtube video, created by Cristoffer Sevilla! www.youtube.com/watch?v=P5Gi... Like and subscribe to our Youtube channel for more updates! 🖥️🧬
youtube.com
Contributing to Reactome
YouTube video by Reactome Knowledgebase
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Reactome @reactome.org · 02/04/2025
Reactome Release News: V92 of #Reactome is live! 🎉 We have exciting new and updated topics and pathways in this release. This release, we added 81 new reactions to Reactome, which you can read about at this link: reactome.org/about/news/2... 🖥️🧬
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Reposted by Reactome
Reactome @reactome.org · 14/02/2025
Discover Pathways with Ease! Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/ 🧬🖥️ 🧪
GIF showing interacting with the Reactome AI chatbot. The chatbot gives a quick explanation of ECM signaling and offers clickable links to Reactome's knowledgebase.
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Reactome @reactome.org · 14/02/2025
Discover Pathways with Ease! Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/ 🧬🖥️ 🧪
GIF showing interacting with the Reactome AI chatbot. The chatbot gives a quick explanation of ECM signaling and offers clickable links to Reactome's knowledgebase.
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Reactome @reactome.org · 04/02/2025
Check out the Reactome Research Spotlight 💡 for February 2025. The paper "BPP: Biochemical Pathway Prediction framework" by Yi et al is summarized here: reactome.org/content/reac... If you have a publication that leverages Reactome, please submit them to help@reactome.org!
reactome.org
BPP: a platform for automatic biochemical pathway prediction - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 13/01/2025
The #ReactomeResearchSpotlight for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids 🖥️🧬
reactome.org
A living organoid biobank of patients with Crohn’s disease reveals molecular subtypes for personalized therapeutics - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reposted by Reactome
EMBL-EBI @ebi.embl.org · 09/01/2025
🔓Juan Antonio Vizcaino on open data practices in proteomics, highlighting data reuse activities in the context of big data approaches 💻Eliot Ragueneau demonstrating @reactome.org GSA for multi-omics data analysis #FoG2025
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Reactome @reactome.org · 19/12/2024
Release News: V91 of #Reactome is live! 🥂 🎉 We have exciting new and updated topics and pathways in this release, which you can read about at this link: reactome.org/about/news/2...
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Reposted by Reactome
Reactome @reactome.org · 15/11/2024
Please consider spending a few moments of your day supporting our resource by providing your feedback to our team! The things we learn from the user survey is essential for our continued success! 🖥️🧬
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Reposted by Reactome
Reactome @reactome.org · 01/11/2024
Let's play 20 questions! If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1F... 🧪🖥️🧬
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Reactome @reactome.org · 26/11/2024
Do you know about ALL the ways you can download #Reactome? Check out our latest youtube video created by Cristoffer Sevilla describing our downloadable materials! Don't forget to share and like our video: youtu.be/UJfPfWpq9lA 🖥️🧬
youtu.be
Reactomes Downloadable materials
YouTube video by Reactome Knowledgebase
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Reactome @reactome.org · 20/11/2024
Come speak to @reactome.bsky.social representatives at the @medicinebydesign.bsky.social symposium in Toronto on Dec 9th! We will be giving away some goodies and giving a sneak peak of our new AI features!
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Reactome @reactome.org · 15/11/2024
Reposting a great starter pack:
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Reactome @reactome.org · 15/11/2024
Please consider spending a few moments of your day supporting our resource by providing your feedback to our team! The things we learn from the user survey is essential for our continued success! 🖥️🧬
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Reactome @reactome.org · 01/11/2024
Let's play 20 questions! If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1F... 🧪🖥️🧬
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Reactome @reactome.org · 15/10/2024
An exciting #ReactomeResearchSpotlight! In the feature article of the October 2024 issue of Drug Discovery Today titled "Chemical coverage of human biological pathways" by Kwak et al. describe the #Target2035 initiative! Read more: reactome.org/content/reac...
reactome.org
Chemical coverage of human biological pathways - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 03/10/2024
Release News: V90 of #Reactome is live! 🥂 🎉 We have new and updated topics and pathways in this release, including Cellular response to stimuli, Disease, Gene Expression, Metabolism, and Metabolism of Proteins, which you can read about at this link: reactome.org/about/news/2... 🖥️🧬
reactome.org
V90 Released - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 23/09/2024
We were thrilled to collaborate with Biobox Analytics on an article exploring Reactome’s curation practices and our innovative graph database! Check it out! 🖥️🧬 blog.biobox.io/p/the-reacto...
blog.biobox.io
The Reactome Knowledgebase: Powering Biological Research with Knowledge Graphs
A look into how the best scientists and system biologists organize biological information.
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Reactome @reactome.org · 17/09/2024
Time for #ReactomeResearchSpotlight! Bracha et al. use #Reactome expression analysis to confirm that they successfully delivered multiple large therapeutic proteins across the blood-brain barrier into target neurons in mice using engineered Toxoplasma gondii secretion systems. 🧬🖥️
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Reactome @reactome.org · 10/09/2024
Going to #ASHG2024🏔? Reactome is coming to Denver, CO! Come talk to Nancy T Li in the #OmicsTechnology session about the #Reactome knowledgebase, and how you can use our data and analysis tools in your research! Please reach out if you'd like to chat! 🧪🖥️🧬
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Reactome @reactome.org · 31/07/2024
Need a ~3 minute intro to #Reactome's analysis tools? Check out our latest youtube video created by Cristoffer Sevilla describing our qualitative and quantitative data analysis methods! Don't forget to share and like our video: youtu.be/rxEpA-lJguE?... 🧪 🖥️🧬
youtu.be
Reactomes Analysis Tools
Welcome to the Reactome's Analysis Tools! In this video, we will show you the Reactome's Analysis Tools, "Analyse Gene List" and "Analyse Gene Expression" so you can learn more about your data in the context of Reactome pathways. Visit our user guide for more detailed information: https://reactome.org/userguide/analysis Find out more at www.reactome.org ! Contact us at help@reactome.org For more information about Reactome, please visit our tutorial: https://www.ebi.ac.uk/training/online... Stay tuned for more videos! Reactome is open-source and open-access, available to anyone. For more information, visit: https://reactome.org/license --- Song Elevate by Benjamin Tissot. Music: https://www.bensound.com License code: 3B3JBRJXEV7GSQFY
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Reactome @reactome.org · 04/07/2024
Have you seen our latest #ReactomeResearchSpotlight? This month's focused on the recent work by Chen et al. reactome.org/content/reac... Chen et al used data simulated based on Reactome pathways to validate their Functional Representation of Gene Signatures (FRoGS) algorithm. 🧬🖥️
reactome.org
Reactome Research Spotlight - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
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Reactome @reactome.org · 19/06/2024
Release News: V89 of hashtag#Reactome is live! 🥂 🎉 We have numerous new and updated topics and pathways in this release, including an exciting update to the "epigenetic regulation of gene expression" pathway. which you can read about at this link: reactome.org/about/news/2... 🖥️🧬🧪
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Reactome @reactome.org · 13/06/2024
🚨 New paper alert! "ReactomeGSA: new features to simplify public data reuse" discusses enhancements to ReactomeGSA, a tool used for multi-omics pathway analysis. You can now fetch GREIN resources directly for analysis, try it out! doi.org/10.1093/bioi... 🖥️🧬
doi.org
ReactomeGSA: new features to simplify public data reuse
AbstractMotivation. ReactomeGSA is part of the Reactome knowledgebase and one of the leading multi-omics pathway analysis platforms. ReactomeGSA provides a
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Reactome @reactome.org · 30/05/2024
How to cite Reactome? A common question with an easy answer: If you need an individual pathway or diagram, you can use our "Cite us" sidebar functionality! You can also find more information at: reactome.org/cite 🧪🧬🖥️ youtu.be/91eQ6iLeguk
youtu.be
Cite us!
How to cite Reactome? You can always cite one of our publications to link to our database, however, if you need an individual pathway or diagram, you can use our "Cite us" sidebar functionality to ensure your audience can find the exact location of the content you reused. You can also find more information at: https://reactome.org/cite, and as always, you can contact help@reactome.org for guidance.
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FlyBase @flybase.bsky.social · 23/04/2024
Note that links to KEGG/Reactome metabolic pathways are specifically displayed in the Metabolic Pathways subsection of Pathways, alongside similar links to FlyCyc, as well as in the External Data subsection. @reactome.bsky.social
FlyBase gene report for Gapdh1, opened to the Pathways section. The Metabolic Pathways and External Data subsections are also opened, to show FlyCyc Pathways, KEGG Pathways, and Reactome linkouts.
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