Dr. Cho joins NIH from the Icahn School of Medicine at Mount Sinai in New York City.

MSK scientists are part of an international consortium working to determine the biological functions of the roughly 20,000 protein-coding genes in the human genome.

Type 2 diabetes (T2D) arises from genetic susceptibility and chronic metabolic stress, but whether these converge on shared molecular programs in human populations remains unclear. Here, we develop a ...

Zhang et al. develop hPSC-derived pancreatic progenitor organoids that model PDAC initiation and progression. The model reveals that CDKN2A loss is uniquely required for human pancreatic transformatio...

Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...

In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...

Huangfu and colleagues identified two NANOG enhancers from a CRISPR interference (CRISPRi) screen in hESCs. Heterozygous deletions of either enhancer significantly lowered NANOG expression, reduced hE...

At the Clinical Atlas of Variant Effects meeting (CLAVE meeting, July 2024, Pittsburgh USA), we developed recommendations for a draft atlas that can be realized by 2030, with a focus on empowering gen...

Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025

NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...

The ISSCR joined with Research!America, hundreds of biomedical research organizations, and thousands of private citizens from the U.S. scientific community to urge House and Senate appropriators to av...

A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated...

In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD