Reposted by Hoyin Chu
Here is a link to the main paper. The link embedded goes to the Research Briefing. www.nature.com/articles/s41...
nature.com
Sequence and structural determinants of efficacious de novo chimaeric antigen receptors - Nature Biomedical Engineering
A generative protein design workflow addresses important challenges with de novo protein engineering of chimaeric antigen receptors (CARs) to improve targeting of proteins important in cancer and crea...