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Edwin Antony

@professorantony.bsky.social
2.2K followers 2.7K following 208 posts

Professor of Biochemistry at St. Louis University School of Medicine. Passionate about mechanistic & structural enzymology, electron transfer & nucleic acid binding enzymes. Fascinated by Cryo-EM, kinetics, single molecules and student training. Golf Nut!

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Edwin Antony @professorantony.bsky.social · 07/10/2026
The Nitrogenase Supercomplex story is formally published! Looking forward to diving deep into its regulation over the next few years. rdcu.be/E7dGJPeDN3Ya
rdcu.be
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RNA modification papers @rnamod.bsky.social · 18/09/2026
Transcript-wide m6A methylation defines the efficiency of cap-independent translation initiation RNA (New York, N.Y.) · Smolin et al. doi.org/10.1261/rna.081017.126 #RNAsky #RNAmods
doi.org
Transcript-wide m6A methylation defines the efficiency of cap-independent translation initiation
Here, we combined ribosome profiling under conditions of mTOR inhibition and m⁶A mapping to identify distinct subsets of mRNAs that differ in their sensitivity to the suppression of cap-dependent initiation.
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Edwin Antony @professorantony.bsky.social · 02/09/2026
Gorgeous 🎉
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Miloš Tišma @tismaa.bsky.social · 21/07/2026
I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10
biorxiv.org
Chromosome topology gates productive RecA homology search
In homologous recombination, DNA repair depends on recombinase filaments finding homologous templates on chromosomes whose topology is continually remodeled by replication and transcription. How dynam...
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Edwin Antony @professorantony.bsky.social · 09/07/2026
How many years?? One question though. Do you think this complex reorganizes into smaller functional units (similar to our observations with the methanogen nitrogenase supercomplex)?
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Edwin Antony @professorantony.bsky.social · 09/07/2026
I would have thought you would have gone with......
static.klipy.com
Tom Cruise in Jerry Maguire: Show Me The Money!
ALT: Tom Cruise in Jerry Maguire: Show Me The Money!
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trisre.bsky.social @trisre.bsky.social · 06/07/2026
1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
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Edwin Antony @professorantony.bsky.social · 17/06/2026
OMG - this is too funny 🤣. I can relate to being the one user who can use that odd looking thing/machine in the lab 🤣. It makes us useful........ I guess.....................
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Rita Strack @ritastrack.bsky.social · 11/06/2026
Nature Comms is seeking an editor with expertise in clinical infectious diseases urldefense.com/v3/__https:/...
urldefense.com
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Edwin Antony @professorantony.bsky.social · 27/05/2026
www.biorxiv.org/content/10.6... New research space for the group: RNA binding proteins! Been chipping away at this for about 3 years now. But, pretty cool to see how a single PTM in an IDR changes overall configurational states of ordered domains.
biorxiv.org
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Leah @hoxinsocks.bsky.social · 12/05/2026
Please share widely! #chemsky #biosky #edusky #MKE #Milwaukee #Wisconsin #UWM #MSOE #Marquette #Hashtag
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Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
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Leslie B Vosshall PhD @leslievosshall.bsky.social · 17/04/2026
📢🎉@hhmi-science.bsky.social HHMI competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, + salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA
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Edwin Antony @professorantony.bsky.social · 14/04/2026
Lovely!!!!
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Edwin Antony @professorantony.bsky.social · 24/03/2026
So well stated!
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Edwin Antony @professorantony.bsky.social · 11/03/2026
I had a similar experience recently when one of the reviewers on a paper I was reviewing had a whole AI-generated page, but it critiqued the wrong methodology entirely. Yet, it was submitted!!!!! I am petrified. I'm now fully expecting this behavior to show up in grant review as well. YIKES!!!!
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Kathrin Lang @klanglab.bsky.social · 11/03/2026
🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4
cell.com
A modular genetic code expansion approach to site-specific lysine acylations
A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...
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Edwin Antony @professorantony.bsky.social · 02/03/2026
Congratulations!
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Edwin Antony @professorantony.bsky.social · 14/02/2026
I only wish the algorithms get better! But, this is so much a better space!
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Edwin Antony @professorantony.bsky.social · 13/02/2026
We are looking for Postdoctoral Fellows with expertise in Structural Biology. Expertise in CryoEM/CryoET is required. Come join us in St. Louis to work on some amazing enzyme complexes. www.antonylab.org/positions.html APPLY HERE: slu.wd5.myworkdayjobs.com/en-US/Career...
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Ben Larson @blarson.bsky.social · 06/02/2026
If you're interested in the regulation and/or evolution of complex cell behavior, this could serve as an opportunity to join our lab as a postdoc. I would be happy to consult on proposal development if we've got a good alignment of goals, skills, and interests. DMs or emails welcome.
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Edwin Antony @professorantony.bsky.social · 12/01/2026
Sending in the R01 grant with authority.......and then the reviews come back! We now have the perfect video to sum up this experience 😂
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Edwin Antony @professorantony.bsky.social · 07/01/2026
Congrats Mark! Good start to the year indeed!
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Aurele Piazza @aurelepiazza.bsky.social · 06/01/2026
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...
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The EMBO Journal @embojournal.org · 12/12/2025
New methods article: David Fay et al integrate endogenous TurboID labeling and data-independent acquisition mass-spectrometry for in vivo proximity labeling link.springer.com/article/10.1...
link.springer.com
Integrating endogenous TurboID and data-independent acquisition mass spectrometry for in vivo proximity labeling - The EMBO Journal
Proximity labeling has emerged as a powerful approach for identifying protein–protein interaction networks within living systems, particularly those involving weak or transient associations. Here, we ...
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Edwin Antony @professorantony.bsky.social · 11/12/2025
“This should be straightforward“ The sentence that really worries my team when I utter it during meetings with collaborators 🤣
media.tenor.com
a man in a white shirt and tie is sitting at a desk with the caption nothing to it
ALT: a man in a white shirt and tie is sitting at a desk with the caption nothing to it
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I-75 Scientist @flscitriguy.bsky.social · 11/12/2025
I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
files.simpler.grants.gov
PAR-26-121: Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)
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Edwin Antony @professorantony.bsky.social · 10/12/2025
What does phosphorylation do to RPA? This has been a long-standing question in the field of genome integrity. In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer. Thanks to funding from NIGMS to our groups.
media.tenor.com
a man is sitting on a couch with his arms outstretched and making a funny face .
ALT: a man is sitting on a couch with his arms outstretched and making a funny face .
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Edwin Antony @professorantony.bsky.social · 09/12/2025
CryoET exploration today - come on Santa!!!!!!!
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Edwin Antony @professorantony.bsky.social · 09/12/2025
I think a lot of folks are turning down ms reviews. I've done close to 25 this year and it was 10 in the last two months alone. Have another one sitting on my desk! I can never decline as there were so many reviewers who handled our manuscripts this year.
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Sofi Origanti @proforiganti.bsky.social · 01/12/2025
Good news- they are continuing to do administrative supplements but the specific dates for NIGMS are unclear!
files.simpler.grants.gov
PA-26-001: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
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Edwin Antony @professorantony.bsky.social · 01/12/2025
2025 has been quite a successful year in terms of scientific discoveries, publications, grants, etc. But, boy-o-boy, the one word to describe my year and all the uncertainties ........... EXHAUSTED!
media.tenor.com
a man is carrying a suitcase in a living room and says i got nothin ' left
ALT: a man is carrying a suitcase in a living room and says i got nothin ' left
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Edwin Antony @professorantony.bsky.social · 01/12/2025
9/10 emails I get from prospective students/postdoc candidates are Ai-generated. I do respond nevertheless with a simple rejection. Its quite disappointing as they might actually be decent and could be considered, but I cannot differentiate what is being masked.
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Edwin Antony @professorantony.bsky.social · 18/11/2025
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org Expertise in structure refinement and model-building are required. Please share.
antonylab.org
ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE
Edwin Antony Lab Website
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Chris Toseland @christoseland.bsky.social · 05/11/2025
Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...
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Edwin Antony @professorantony.bsky.social · 31/10/2025
Congratulations to all involved. Raises more questions about all the backup mechanisms in HR. So much to unpack here!
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Petr Cejka @cejkalab.bsky.social · 27/10/2025
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...
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Edwin Antony @professorantony.bsky.social · 16/10/2025
This is super cool! Congratulations on a fantastic study. Looking forward to trying out these tricks in our ncAA incorporation setup.
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Kathrin Lang @klanglab.bsky.social · 16/10/2025
🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9
nature.com
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
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giovanniconsoli.bsky.social @giovanniconsoli.bsky.social · 11/10/2025
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠 Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org www.science.org/doi/10.1126/...
science.org
Locating the missing chlorophylls f in far-red photosystem I
The discovery of chlorophyll f-containing photosystems, with their long-wavelength photochemistry, represented a distinct, low-energy paradigm for oxygenic photosynthesis. Structural studies on chloro...
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Florian Roisné-Hamelin @roisnehamelinf.bsky.social · 09/10/2025
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social www.cell.com/molecular-ce...
cell.com
Mechanism of DNA entrapment by a loop-extruding Wadjet SMC motor
Wadjet is an SMC-based prokaryotic defense system that eliminates plasmid DNA. Roisné-Hamelin et al. present structures capturing key steps of its DNA-loading mechanism. This work reveals how Wadjet t...
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Edwin Antony @professorantony.bsky.social · 08/10/2025
Spread the word if you can. We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!
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midwestenzyme.bsky.social @midwestenzyme.bsky.social · 06/10/2025
MECC 2025 was a success at UW-Milwaukee! 153 attendees. 76 poster presenters. Talks by 4 faculty, 1 post-doc, 4 grad students, and 1 keynote. Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs See you next year in Chicago at Loyola University for MECC 2026!
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Edwin Antony @professorantony.bsky.social · 30/09/2025
@midwestenzyme.bsky.social MECC 2025 was a very cool meeting this year. 160 attendees, 80 posters, and great science all around. Thanks to our sponsors @slu-biochemistry.bsky.social @uwmilwaukee.bsky.social Refeyn @ei-science.bsky.social Abbott Inc, Hampton Research, CoAla BioSci, NEB
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Edwin Antony @professorantony.bsky.social · 24/09/2025
That would be amazing to have! Thanks
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Edwin Antony @professorantony.bsky.social · 24/09/2025
ORDERED.......Thanks for the tip!
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Edwin Antony @professorantony.bsky.social · 24/09/2025
Yes, yes, yes .......... I want, I need, I drool! Ordering copies for the group tomorrow...
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Sven T. Stripp @stripplab.bsky.social · 23/09/2025
Folks with Christmas around the corner can I suggest a meaningful present real quick? 🎄
https://www.amazon.de/Iron-Sulfur-Clusters-Biochemistry-Silke-Leimk%C3%BChler/dp/3527352554
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