Sign in

Anthony Chalmers

@profajchalmers.bsky.social
594 followers 152 following 70 posts

Clinician scientist, radiation oncologist, neuro-oncologist Gardens, cocktails, Scotland

PostsRepliesMedia
Reposted by Anthony Chalmers
RTTQA @rttqa.bsky.social · 23/07/2025
Want the opportunity to work at the forefront of RT #clinicaltrials? We are hiring! Band 7 Clinical Scientist/Radiographer. 1-year post, renewable subject to funding: www.enherts-tr.nhs.uk/careers/vaca... Deadline 18th August. DM for further information. #medphys #rtt #rtqa
enherts-tr.nhs.uk
Current vacancies – East and North Hertfordshire NHS Trust
Are you a retired NHS employee? You could join the NHS Retirement Fellowship.
043
Reposted by Anthony Chalmers
Giorgio Seano @giorgioseano.bsky.social · 17/07/2025
🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo... Short walkthrough below. Let’s dive in! 🧵 (1/9) #GBM, #BrainTumor
Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear.
Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population.
Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. 
Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
2146
Reposted by Anthony Chalmers
EANO @eanoassociation.bsky.social · 16/07/2025
🎗️Today is #GlioblastomaAwarenessDay2025, designed to raise awareness of #glioblastoma, the most common primary brain cancer. At #EANO, we are dedicated to advancing scientific research, improving diagnostic tools, & developing therapies to combat this challenging disease. #GBMDay 👉 @braintumor.org
082
Reposted by Anthony Chalmers
Johanna Joyce @johannajoyce.bsky.social · 23/06/2025
Are you looking to start your #lab in a fantastic scientific 🧪environment, with great colleagues, and in a spectacular place to live? Then check out our open #junior #faculty position at the Department of Oncology, University of Lausanne, Switzerland: www.unil.ch/dof/en/home/... ⏰ Deadline 27 June
39150
Reposted by Anthony Chalmers
roberthuddart.bsky.social @roberthuddart.bsky.social · 20/06/2025
Reminder that #ctrad are holding a proposals guidance meeting on 11th July 2025. We have a limited list of contacts to invite but if you are interested in UK radiation research we would love you to join us. Please contact ctrad@macmillan.org.uk for details, register and submit a trial idea.
022
Reposted by Anthony Chalmers
UCSF Radiation Oncology @ucsfradonc.bsky.social · 27/05/2025
Read the latest perspective piece by @sueyom.bsky.social & Mary Helen Barcellos-Hoff in @natrevcancer.nature.com @ucsanfrancisco.bsky.social @ucsfhealth.bsky.social @ucsfcancer.bsky.social
075
Anthony Chalmers @profajchalmers.bsky.social · 01/06/2025
Thank you Robert and MacMillan for reviving #CTRad - the most effective and impactful academic organisation I’ve ever been a part of. The future of #radiotherapy research in the UK is in safe hands.
000
Reposted by Anthony Chalmers
Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 23/05/2025
We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply: www.sussex.ac.uk/study/fees-f...
sussex.ac.uk
Life Sciences PhD Genome Stability - Understanding and Targeting Cell Cycle Control in Cancer : University of Sussex
035
Reposted by Anthony Chalmers
EANO @eanoassociation.bsky.social · 22/05/2025
📢 Reminder: Apply now to join the #EANO Nurse & Allied Healthcare Professional Committee (NAC)! Help shape EANO’s future & represent your field in the #NeuroOncology community. 🗓️ Deadline: May 31 🔗 bit.ly/45kRJyP We look forward to meeting you! @drflorienboele.bsky.social @karinpiil.bsky.social
001
Reposted by Anthony Chalmers
Helfrid Hochegger @helfridh.bsky.social · 21/05/2025
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms Please forward to prospective students! Thank you url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
url.uk.m.mimecastprotect.com
PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex
At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.
013
Reposted by Anthony Chalmers
Peter Stefanovic @peterstefanovic.bsky.social · 19/05/2025
“Starmer's EU deal is a big break in the suffocating Brexit consensus that has held Britain back for a decade. For the first time a UK government is doing things to actually undo the damage of Brexit, rather than increase it. For that alone it should be welcomed” 👏 bylinetimes.com/2025/05/19/k...
bylinetimes.com
Keir Starmer's EU Reset Deal Is the First Crack in the Brexit Wall Holding Britain Back
This agreement marks the beginning of the end of the suffocating Brexit consensus that has gripped British politics for a decade, argues Adam Bienkov
331423302
Reposted by Anthony Chalmers
Tessa Jowell Brain Cancer Mission @tessajowellbcm.bsky.social · 14/05/2025
🧠New Neurology Fellowship Opportunity in London! Join a cutting-edge Fellowship programme, designed to deepen your clinical expertise in the evolving field of neuro-oncology. 🔗Find out more here: www.tessajowellbraincancermission.org/news/tessa-j... @nihr.bsky.social @kingshealth.bsky.social
001
Reposted by Anthony Chalmers
Healthcare in Europe @healthcare-europe.bsky.social · 12/05/2025
Five studies presented by experts including @montefiored.bsky.social from 🇬🇧 @universityofleeds.bsky.social / @leedsth.nhs.uk, 🇳🇱 @nkinl.bsky.social, and 🏴󠁧󠁢󠁳󠁣󠁴󠁿 @uofgcancersciences.bsky.social at #ESTRO25 showcase how #radiotherapy is reshaping treatments for anal and rectal #cancer.
healthcare-in-europe.com
Five major advances in anal and rectal cancer treatment with radiotherapy
Rectal cancer is a type of bowel cancer that develops in the last several centimetres of the large intestine, just before the anus. It’s one of the most common cancers in Europe, with over 125,000 peo...
043
Reposted by Anthony Chalmers
Ros Taylor @rostaylor.bsky.social · 05/05/2025
Or to put it another way, overseas students now subsidise the cost of teaching each UK undergraduate by an average of £2,500 each. Take them away and you've got an absolutely existential crisis for universities. www.prospectmagazine.co.uk/politics/pol...
prospectmagazine.co.uk
How universities were sent over the edge
UK higher education institutions did as the government asked and took on more students. Now many face collapse
27485259
Reposted by Anthony Chalmers
Henning Willers, MD, FASTRO @henningwillersmd.bsky.social · 03/05/2025
🔈 I am honored to be running alongside Sunil Krishnan & David Yu for Vice-President Elect of RRS 🙏🙏🙏 🧐You can find more info on the candidates here 👉 ftp.ameetingbydesign.com/ambddrop/202... Vote by May 1️⃣3️⃣ radres.org/Login.aspx @cvanpouillebox.bsky.social @profajchalmers.bsky.social
042
Reposted by Anthony Chalmers
Johan Vande Voorde @johanvandevoorde.bsky.social · 03/05/2025
!!*RECRUITING*!! We are looking for an enthusiastic PhD student @cruk-si.bsky.social @uofglasgow.bsky.social! This exciting fully funded project aims to unravel metabolic determinants of cachexia. Fancy some great teamwork with the labs of Owen Sansom and Campbell Roxburgh? Apply below!👇
145
Reposted by Anthony Chalmers
Alison Tree @alison-tree.bsky.social · 03/05/2025
HYPO-RT-PC 10 year data presented at #ESTRO2025. Seven fractions def non-inferior to 39 fractions, suggestion that 7 fractions might even be more likely to cure?
0122
Reposted by Anthony Chalmers
Brain Tumour Research @braintumourrsch.bsky.social · 01/05/2025
Job alert: Clinical Lead wanted for the new UK Collaborative for Cancer Clinical Research (UKCCCR) – part of the Govt’s Cancer Healthcare Goals Programme. 💼 1 day/week (consultancy) | Hosted by @amrc-uk.bsky.social  proudly supported by us. Apply here 👉
amrc.org.uk
Clinical Lead, UK Collaborative for Cancer Clinical Research (UKCCCR)
Salary: up to £21,000 for 0.2FTE Location: Hybrid working (home and office in central London, WC1)  Deadline: 8am, Monday 12th May 2025 Duration: one year fixed term (initially, with the expectation that the role will be renewed) Secondments welcome About the role AMRC has agreed to host the secretariat for a new UK Collaborative for Cancer Clinical Research (UKCCCR), which will be part of the Government’s Cancer Healthcare Goals Programme. A number of Cancer Clinical Research Groups (CRGs), each focusing on a specific cancer type or cross-cutting theme, bring together the cancer research community, to encourage strategic discussion and identify new areas of research. Many of the Secretariats for the CRGs are now run by AMRC member charities. The UKCCCR will provide a light touch secretariat to improve central coordination of these groups, allowing them to identify shared priorities, reduce duplication and be as effective as possible. The Clinical Lead will provide clinical expertise, advice and leadership on a consultancy basis to support UKCCCR and the programme manager. The role will require up to one day a week time commitment on a flexible basis. Please see the job description and person specification for full details.  How to apply Please read the job description and person specification. Please send your CV and a cover letter explaining what makes you a strong candidate for this role to jobs@amrc.org.uk. Please quote ‘UKCCCR Clinical Lead’ in the email subject.  If you have any questions about the role, or wish to have an informal conversation, please email jobs@amrc.org.uk.
022
Reposted by Anthony Chalmers
Richard Simcock @breastdocuk.bsky.social · 02/05/2025
Runcorn worn by 6 votes on a turnout of only 46.2% tells me two things: Your vote is always important Too many people think it isn’t
011
Anthony Chalmers @profajchalmers.bsky.social · 30/04/2025
Spring and summer happened on the same day this year! #glasgow
130
Reposted by Anthony Chalmers
Cancer Research UK @cancerresearchuk.org · 27/04/2025
Anthony Chalmers presents studies on combining radiation therapy and DNA damage response inhibitors, potential mechanisms and clinical implications. #AACR25 | @profajchalmers.bsky.social
131
Reposted by Anthony Chalmers
John McGrane @jmcgrane.bsky.social · 24/04/2025
New episode of Simply Oncology coming for Head and Neck patients. 🎙️We speak to the superb @clairepaterson.bsky.social about radiotherapy and new treatments in H&N cancers. 🎙️A great resource for any patient undergoing H&N treatment @simplyoncology.bsky.social
055
Anthony Chalmers @profajchalmers.bsky.social · 14/04/2025
Congratulations to the authors for completing this randomised study in an extremely rare cancer. Clear evidence of overall survival benefit from the addition of chemoradiation to standard of care. #radonc
052
Anthony Chalmers @profajchalmers.bsky.social · 05/04/2025
How brilliant is this?! Well done Cassie for continually pushing the boundaries of what scientists can do.
140
Reposted by Anthony Chalmers
EANO @eanoassociation.bsky.social · 03/04/2025
📢 Call for Applications EANO & @neuroonc.bsky.social are seeking a new Editor-in-Chief for Neuro-Oncology Advances! ✅ Strong background in #NeuroOncology ✅ Editorial leadership experience 🗓️ Deadline: May 31, 2025 🔗 More info: bit.ly/4j9AqV7 #EANO #SNO #NeuroOncologyAdvances #CallForApplications
046
Anthony Chalmers @profajchalmers.bsky.social · 29/03/2025
Wish me luck…
370
Reposted by Anthony Chalmers
Ananya Choudhury @achoud72.bsky.social · 29/03/2025
👀 for a #postdoc to join us. #Ttanslational #Radiobiology #Immunemicroenvironment If you're interested, get in touch @mcrcnews.bsky.social @uniofmanchester.bsky.social www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Associate in Translational Radiobiology:CRUK Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ
013
Anthony Chalmers @profajchalmers.bsky.social · 25/03/2025
Definitely a sense of spring on campus today - hooray!@uofglasgow.bsky.social
191
Reposted by Anthony Chalmers
Cancer Research UK Scotland Institute @cruk-si.bsky.social · 18/03/2025
🚨Last chance to register for the Beatson International Cancer Conference 2025 #BICC2025 - Cancer Models: from Data to Discovery Register by Friday 21 March: www.beatsonconference.org/
054
Reposted by Anthony Chalmers
Trevor Graham @trevorgraham.bsky.social · 21/03/2025
Ben O'Leary & I are looking for a #postdoc to join us in @cec-icr.bsky.social to work on collaborative @cancerresearchuk.org RadNet project about the interrelationship between genome & epigenome instability and radiotherapy response. Details & apply here: jobs.icr.ac.uk/vacancies/11... @icr.ac.uk
jobs.icr.ac.uk
Postdoctoral Training Fellow - Evolution & Translational Genomics in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Evolution & Translational Genomics vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Future progre...
11522
Reposted by Anthony Chalmers
The Association for Radiation Research @assocradres.bsky.social · 21/03/2025
📢 Reminder! The extended deadline for abstracts is 23rd March 2025—don’t miss your chance to share your great science! 🧪✨ Slots available for oral & poster presentations—submit now! 🔬📢 👉 uobevents.eventsair.com/arr-2025
uobevents.eventsair.com
ARR - ARR 2025
Annual Association for Radiation Research Conference 2024 homepage
012
Reposted by Anthony Chalmers
EANO @eanoassociation.bsky.social · 19/03/2025
🚀From Glasgow to Prague: Shaping the Future Together! #EANO2024 in Glasgow was a huge success with unforgettable moments & inspiring talks! Watch the highlights bit.ly/3WL1oKg and get excited for #EANO2025 in Prague! What are you most excited about? #NeuroOncology
073
Reposted by Anthony Chalmers
Brian Elliott @brianelliottmd.bsky.social · 18/03/2025
The irony of an article discussing the unpaid labor of scientists, published by a $4bn corporation reliant on the unpaid labor of scientists. Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today #academicSky #medSky #research
nature.com
I spent two years organizing an international conference. How do I get compensated for my work?
It can be hard to say no to service requests in academia. Nature’s Careers team sought advice on how to ensure researchers don’t get stuck doing unpaid labour.
0166
Anthony Chalmers @profajchalmers.bsky.social · 14/03/2025
Huge congratulations to Kathy on a wonderful PhD thesis - you have a very exciting career ahead of you! 💐🥂 Also to Jo - a superb job done supervising your first PhD student 👏👏👏
040
Reposted by Anthony Chalmers
John McGrane @jmcgrane.bsky.social · 13/03/2025
🎙️@simplyoncology.bsky.social episode on #BladderCancer out 14/03/2025 🎙️We talk to leading bladder radiotherapy expert Professor Ananya Choudhury. 🎙️@achoud72.bsky.social discusses her views on bladder preservation and radiotherapy. 🎙️Fascinating insights from a world expert in bladder cancer 👇
012
Reposted by Anthony Chalmers
Brain Tumour Research @braintumourrsch.bsky.social · 11/03/2025
A reminder that the Rare Cancers Bill has its Second Reading this Friday. If you haven't already done so, contact your MP and ask for their support in attending this important vote. #BackTheBill #BrainTumourResearch @drscottarthurmp.bsky.social
032
Reposted by Anthony Chalmers
EANO @eanoassociation.bsky.social · 11/03/2025
📅 Mark your calendars! Abstract submissions for #EANO2025 are due April 30. Don’t miss your chance to showcase your #NeuroOncology research this October! 🌍✨ 🔬 Submit now: www.eano.eu/eano2025/abs... #btsm #neurosurgery #glioma #RadOnc #BrainCancer #cancernurse #AHP
033
Anthony Chalmers @profajchalmers.bsky.social · 10/03/2025
Congratulations to Alison and the team on completing this challenging study - and for exciting results! #radonc #SBRT
150
Reposted by Anthony Chalmers
Johanna Joyce @johannajoyce.bsky.social · 08/03/2025
Giving thanks for all amazing and inspiring women around the world on International Women’s Day We will never give up fighting for equality, for what is just and fair, and for each other 💪 #WomenOfTheWorldUnite #WomenInScience 🧪
photo of the 1970 march showing a crowd of women and the banner ‘women of the world unite’
014937
Reposted by Anthony Chalmers
Magdalena Skipper @magdalenaskipper.bsky.social · 08/03/2025
Women in research need the credit & recognition they deserve for the amazing contributions they make. Nature Awards for Inspiring Women in Science are open for applications - take a look 👇🏻 & help spread the word #WomeninSTEM #AcademicSky 🧪 @natureportfolio.nature.com www.nature.com/immersive/in...
nature.com
Nature Awards Inspiring Women in Science
Celebrating and supporting the achievements of women in science, and all those who work to encourage girls and young women to engage with STEM subjects and stay in STEM careers around the world.
013380
Reposted by Anthony Chalmers
James Briscoe @jamesbriscoe.bsky.social · 06/03/2025
This is why UK gov needs to invest in PhD training & cut visa costs for scientists Long term economic growth depends on skilled people The UK should make the most of life sciences
13816
Reposted by Anthony Chalmers
EANO @eanoassociation.bsky.social · 05/03/2025
🚀Abstract submission for #EANO2025 is open! Share your #NeuroOncology research at the 20th #EANO Meeting in Prague, Oct 16-19, 2025. We can't wait to see your contributions! 🗓️ Deadline: April 30, 2025, 23:59 CEST. 🔗 Details: www.eano.eu/eano2025/abs... #btsm #braintumor
0119
Reposted by Anthony Chalmers
The Brain Prize @brainprize.org · 05/03/2025
Congratulations to winners of The Brain Prize 2025! Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience. Learn more: brainprize.org/winners/canc...
114036
Reposted by Anthony Chalmers
Silvia Marino @smarino0111.bsky.social · 04/03/2025
Interested in #epigenetics #genomewide #screen #glioblastoma #braintumours? Check out this exciting opportunity to join us @blizardinstitute.bsky.social @qmul.ac.uk
jobs.ac.uk
Postdoctoral Research Associate at Queen Mary University of London
Apply for the Postdoctoral Research Associate role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
032
Reposted by Anthony Chalmers
Alison Tree @alison-tree.bsky.social · 02/03/2025
Calling academic friends. We could have seen this coming but I failed to plan ahead. What is the best alternative to Pubmed?
343
Reposted by Anthony Chalmers
Trish Greenhalgh @trishgreenhalgh.bsky.social · 28/02/2025
The populist right is damaging US science. The UK could be next. New from @kityates.bsky.social open.substack.com/pub/kityates...
open.substack.com
The populist right is damaging US science. The UK could be next.
What we should be doing now to insulate UK science against the populist anti-science agenda
721990
Reposted by Anthony Chalmers
Ananya Choudhury @achoud72.bsky.social · 28/02/2025
Nuradh & team show the importance of whole body integral RT dose and post treatment lymphocytopenia. @official-uom.bsky.social @mcrcnews.bsky.social @ipemnews.bsky.social @rcradiologists.bsky.social @christielibrary.bsky.social @oncoalert.bsky.social bmjoncology.bmj.com/content/4/1/...
bmjoncology.bmj.com
Whole-body integral dose and post-radiotherapy lymphocytopaenia in solid tumours
Objective Since modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) pivot on a strategy of dose redistribution, it may increase integral dose and consequently worsening of l...
095
Reposted by Anthony Chalmers
Brain Tumour Research @braintumourrsch.bsky.social · 27/02/2025
We’re hiring! 🚨 Join Brain Tumour Research and help drive our mission to find a cure. 💛 🔹Head of Philanthropy & Partnerships 🔹Fulfilment Manager 🔹Community Fundraiser Apply now! ➡️ bit.ly/4ih6uWG #CharityJobs#BrainTumourResearch #JoinOurTeam
021
Reposted by Anthony Chalmers
Tim 🏳️‍🌈🇨🇦🖖🏻 @timwhotravels.bsky.social · 26/02/2025
#equality #lgbtq+
332495595