The conference program will aim to highlight the constant evolution throughout life of the developmental, immune and neuronal contexts of brain tumors The thematic sessions will seek to establish lin...

Dexamethasone reprograms glioblastoma nicotinamide metabolism, sensitizing tumors to methionine restriction and enabling PET.

Giorgio Seano: Why Does Glioblastoma Always Outsmart Treatment? / Adrien Thomas, Alberto Ballestín, cancer, Cathy Pichol-Thievend, Celine Vallot, Curie

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Dans le cadre de son programme de recherche intégrée « Cerveau, cancer et immunité – dialogue cellulaire dans les tumeurs cérébrales », […]

Glioblastoma (GBM) is the most common and lethal form of primary brain cancer. Microglia infiltration into the tumor microenvironment is associated wi…

Cell persistence and senescence are distinct states of proliferative arrest induced by cancer therapy, with persister cells being characterized by the silencing of inflammatory genes through the heter...

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic ...

Sapkota et al. show that hypoxia triggers vascular breakdown and microglial activation in the brain. While return to normoxia results in vascular repair, m

Glial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in the zebrafish BBB remains unclear. Using three glial gene promoters—gfap, glast, and glastini (a truncated glast)—we explored glial-vascular development in zebrafish. Sparse labeling showed fewer glial-vascular interactions at early stages, with glial coverage and contact area increasing with age. Stable transgenic lines for glast and glastini revealed similar developmental increases, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% by 10 dpf, and consistently higher glial coverage in the forebrain and midbrain than in the hindbrain.

Biomacromolecules are delivered across the blood–brain barrier when administered systemically.

Job Title: Associate or Senior Editor, Nature Locations: New York or Berlin (Hybrid working model) Application Deadline: December 15th, 2024 About Springer Nature Group Springer Nature opens the doors...

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The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.