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Pablo Ivan Nikel

@pabnik.bsky.social
1.1K followers 379 following 51 posts

Professor DTU Biosustain · Proud PI @labnikel.bsky.social · SynBio · Metabolic Engineering · @novo-nordisk.bsky.social Ascending Investigator & Distinguished Innovator · He/him🏳️‍🌈

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Reposted by Pablo Ivan Nikel
International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 06/09/2026
¿Por qué la cuajada, el kimchi y la kombucha interesan a los científicos? ¡Porque tu intestino alberga TRILLONES de microorganismos! Los probióticos aportan microorganismos beneficiosos. Los prebióticos los alimentan. Los simbióticos hacen ambas cosas. grupos.eez.csic.es/imili/wp-con...
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Reposted by Pablo Ivan Nikel
Weizmann Institute of Science @weizmann.ac.il · 31/08/2026
We, the Weizmann Institute of Science community, deeply mourn the passing of Prof. Ada Yonath - Nobel Laureate and a Model of Scientific Perseverance. May her memory be a blessing. bit.ly/ada-yonath-eng
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Tom Ellis @proftomellis.bsky.social · 31/07/2026
Our lab’s latest on synthetic genomics “Synthetic Combinatorial Minimisation of Cell Cycle Control” is up now on BioRxiv - covering ambitious yeast #synbio cell cycle work led by Anastasiya Malyshava and co-supervised by Matteo Barberis.
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CarboNcare @carboncare-project.eu · 28/07/2026
Hello! We are a new @scienceinnovation.ec.europa.eu project building bacteria that only grow by making methanol-based chemicals instead of releasing CO2. 🌬️🦠 📈 Follow our journey and learn more at carboncare-project.eu Eight partners, six countries, one goal: Fermentation 2.0. #microsky 🧪
Sixteen people standing together and posing for a picture under the shade of a tree at a university campus.
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Lars Dietrich @laahrs.bsky.social · 28/06/2026
Phenazine Pride #PrideMonth #bacterial_pigments Agar art by Marina Smiley
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Pablo Ivan Nikel @pabnik.bsky.social · 23/06/2026
PntAB & SthA of #Pseudomonas are a flexible transhydrogenase system, supporting energy balance, acetate assimilation & formate tolerance, impacting redox-intensive & C1 metabolic engineering @michelepartipilo.bsky.social @labnikel.bsky.social @cp-cellsystems.bsky.social www.cell.com/cell-systems...
cell.com
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Pablo Ivan Nikel @pabnik.bsky.social · 11/06/2026
Cascading recombinase memory switch for programmable and stable gene expression in Pseudomonas putida by Javier Hernández @labnikel.bsky.social #SyntheticBiology #MetabolicEngineering #GeneticCircuit #OpenAccess academic.oup.com/nar/article/... @narjournal.bsky.social
academic.oup.com
Cascading recombinase memory switch for programmable and stable gene expression in Pseudomonas putida
Abstract. Genetic circuits for model bacteria often perform poorly in non-canonical hosts, limiting the deployment of regulatory programs in industrially r
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Reposted by Pablo Ivan Nikel
Seán Ferrick @seanferrick.bsky.social · 01/06/2026
Happy Pride Month! LGBTQIA+ lives are increasingly at risk in 2026, but you'll probably see the usual 'things are better/acceptance has increased/stop shoving it in our faces' No. Love loud, continue to fight, support queer art and businesses, and stand up for your trans siblings :)
static.klipy.com
Elmo's Rainbow Pride Celebration
ALT: Elmo's Rainbow Pride Celebration
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Pablo Ivan Nikel @pabnik.bsky.social · 30/03/2026
#Pseudomonas vancouverensis as a platform for one-carbon (#C1) assimilation and #polyhydroxyalkanoate accumulation, led by Emil C. Ørsted @labnikel.bsky.social #Biotechnology #MetabolicEngineering #SynBio www.sciencedirect.com/science/arti...
sciencedirect.com
Pseudomonas vancouverensis as a platform for one-carbon (C1) assimilation and polyhydroxyalkanoate accumulation
Metabolic engineering calls for new bacterial chassis that combine robust metabolic and physiological traits with genetic tractability. We developed P…
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Reposted by Pablo Ivan Nikel
Natural Product Reports @natprodreports.rsc.org · 13/03/2026
🔓Check out the #OpenAccess review by @pabnik.bsky.social & co. @labnikel.bsky.social in our latest issue exploring emergent strategies and methods for isolating, creating & characterizing enzymes optimized for bioproduction #natprod Read in full on our website🔽
pubs.rsc.org
Accelerating enzyme discovery and engineering with high-throughput screening
Covering: up to August 2024 Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable…
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Reposted by Pablo Ivan Nikel
Amelia Rotaru @ameliarotaru.bsky.social · 12/03/2026
💫 I am recruiting a postdoctoral candidate for a 3-year position starting in summer 2026 to work on the role of extracellular RNA (eRNA) in interspecies interactions.
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Pablo Ivan Nikel @pabnik.bsky.social · 26/02/2026
Very sad news about the passing of Prof. Jeff Cole. Jeff was a central figure for biotechnology in Europe who inspired generations of researchers. R.I.P.🕊️
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Microbial Biotechnology (MBT) @microbiotech.bsky.social · 29/01/2026
#MicroSky: Plasmid vectors still underpin molecular biology, but convenience shouldn’t trump design. De Lorenzo & Martínez revisit copy number, selection & stability, and explores modular AI-assisted vector design for robust synthetic biology across the microbial world. doi.org/10.1111/1751...
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 27/01/2026
How do you react when your favorite microbe is renamed by taxonomists who are completely outside your field—and who ignore the community that actually works with it? Here is our clear answer re the case of Pseudomonas putida KT2440 👉🏻 journals.asm.org/doi/10.1128/...
journals.asm.org
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio
Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term use and broad ad...
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Pablo Ivan Nikel @pabnik.bsky.social · 27/01/2026
Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio
Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term use and broad ad...
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Ken Timmis @kentimmis.bsky.social · 16/12/2025
this is also a contribution to the Scientists' Warning to Humanity series @scientistswarning.bsky.social
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Reposted by Pablo Ivan Nikel
Ken Timmis @kentimmis.bsky.social · 16/12/2025
Happy to post our latest paper: doi.org/10.1111/1751... Biases accumulate with age, so it is essential to begin teaching critical thinking as early as possible. The problems are HOW, given the complexity of its theory, and IN WHAT EDUCATIONAL CONTEXT? The solutions we propose in this paper are...
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Ken Timmis @kentimmis.bsky.social · 07/12/2025
Microbes determine the health of all other organisms and that of the planet. They were our ancestors and are our cousins. They are life and sustain it. Microbes are life, the biological core of One Health and Health in All Policies url: academic.oup.com/microlife/ar...
academic.oup.com
Microbes are life, the biological core of One Health and Health in All Policies
The World Health Organization (WHO) is promoting the operative concept of “Health in All Policies” (HiAP; https://iris.who.int/bitstream/handle/10665/11263
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🌈 Dr Ross Brooks @rossbrooks.co.uk · 07/11/2025
So excited that the theme of LGBT+ History Month UK 2026 is 'Science and Innovation,' with super badge designed by @canopyrobin.com! 🧬🏳️‍⚧️🔭🏳️‍🌈🚆 Wonderful launch event at the Royal Society of Chemistry @rsc.org this evening. 👏 lgbtplushistorymonth.co.uk/lgbt-history... @lgbthm.bsky.social #LGBTplusHM 🌈🗃️
lgbtplushistorymonth.co.uk
LGBT+ History Month 2026 - LGBT+ History Month
If you’d like to donate to support our work, click here to donate via PayPal. Free Schools Presentation For 2026 we are able to offer free LGBT+ History Month presentations for secondary schools, prid...
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Pablo Ivan Nikel @pabnik.bsky.social · 03/11/2025
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin — Led by Leah Bushin, featuring M. Gracia Alvan, @danielvolke.bsky.social @oscarpuiggene.bsky.social in a fantastic collaboration w/Brad Moore @labnikel.bsky.social @natbiotech.nature.com 🦑 www.nature.com/articles/s41...
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labnikel.bsky.social @labnikel.bsky.social · 22/08/2025
🚨 New paper in mBio! We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10.... Here’s a teaser of how we did it 🧵👇1/5
journals.asm.org
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
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labnikel.bsky.social @labnikel.bsky.social · 08/10/2025
3/4 Our perspective lays out: 1️⃣ A blueprint for designing next-gen synthetic C1 microbes 2️⃣ A roadmap for engineering P. putida into an autotrophic chassis 3️⃣ A circular carbon economy vision, revalorizing CO₂ + waste streams 📊 Together, these steps connect design → engineering → sustainability.
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labnikel.bsky.social @labnikel.bsky.social · 08/10/2025
🚀 Thrilled to share our new Nature Communications article: “A blueprint for designing the next-generation of synthetic C1 microbes” We propose a framework to unlock sustainable, carbon-efficient biomanufacturing using non-canonical hosts. 🔗 www.nature.com/articles/s41... A short 🧵1/4
nature.com
A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications
Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.
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Pablo Ivan Nikel @pabnik.bsky.social · 03/10/2025
A blueprint for designing the next-generation of #synthetic C1 #microbes @natureportfolio.nature.com / We outline how to engineer non-canonical hosts, apply modeling & C1-inducible promoters & integrate sustainability metrics for carbon-efficient #biomanufacturing www.nature.com/articles/s41...
nature.com
A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications
Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.
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Pablo Ivan Nikel @pabnik.bsky.social · 24/09/2025
The very 1st #Course on #SynBio & #Metabolic #Engineering of #Pseudomonas at Cold Spring Harbor Asia successfully completed in Suzhou, #China! Excellent group of students & lecturers, w/time for culture, food & stand-up paddling alongside the science—thanks to all who participated & stay tuned 4+!
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Reposted by Pablo Ivan Nikel
International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 23/09/2025
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 24/09/2025
Who is afraid of HGT? True, antibiotic resistances disseminate through it. But we can also leverage the same channels for spreading good stuff at a very large scale and fortifying the env microbiome with beneficial activities www.biorxiv.org/content/10.1... by Victor Maull & @ricardsole.bsky.social
biorxiv.org
Synthetic Horizontal Gene Transfer for Ecosystem Restoration
Restoring endangered ecosystems has become a pressing issue as the effects of global warming continue to harm existing communities. Over the last decade, several studies have suggested the use of synt...
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Andreas P.M. Weber 🌾🌱🧬 @apmweber.bsky.social · 03/09/2025
We are deeply saddened by the news that Andrew D. Hanson (@adhansonlab.bsky.social) is no longer with us. He was an exceptional scientist, mentor, and leader in multiple fields. He constantly reminded us that over-promising would backfire. Rest in peace, Andrew.
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Pablo Ivan Nikel @pabnik.bsky.social · 02/09/2025
Delighted to join #MetabolicEngineering as Associate Editor w/Sang Yup Lee, Jay Keasling, I. Borodina, C. Maranas & C. Wittmann. I'll handle submissions in #SyntheticMetabolism, #Pseudomonas, #SynBio, new-to-nature #bioproduction & #EnvironmentalBiotechnology!
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Pablo Ivan Nikel @pabnik.bsky.social · 21/08/2025
Saying goodbye to Elio Schaechter, a titan of the #Microbiology field. Farewell Elio!
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Pablo Ivan Nikel @pabnik.bsky.social · 21/08/2025
#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio journals.asm.org/doi/10.1128/...
journals.asm.org
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
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Reposted by Pablo Ivan Nikel
SEVA Plasmids @sevaplasmids.bsky.social · 16/07/2025
🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011
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TOLERATE EU Project @tolerateeu.bsky.social · 15/07/2025
📍 Milan | TODAY! Join Amedea Perfumo & @pabnik.bsky.social at #FEMS 2025 for a dynamic session🧬 "Something (very) old, something new: Innovative microbial solutions for sustainability challenges 🕦 15 July | 11:30–13:00 | Tower Lounge 🔗 femsmicro.org ▶️ youtu.be/0-bhcMpjJ_c #TolerateEUProject
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Pablo Ivan Nikel @pabnik.bsky.social · 13/07/2025
Looking forward to see old MicroFriends and make some new ones at #FEMS2025!
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labnikel.bsky.social @labnikel.bsky.social · 09/07/2025
Check out our newest article led by @oscarpuiggene.bsky.social !
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labnikel.bsky.social @labnikel.bsky.social · 09/07/2025
The 5th edition of the #Pseudomonas grass roots meeting will take place on the 27th/28th of October 2025 in Denmark. This year, our group at DTU Biosustain will host 2 exciting days of networking, exchanging ideas and learning for early career-stage scientists working with Pseudomonas. 👇
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SEVA Plasmids @sevaplasmids.bsky.social · 09/07/2025
🧬 The language of SEVA expands! The group of @pabnik.bsky.social use #SEVAplasmids nomenclature in the design of CIFR—a novel iterative transposon tool for genomic engineering of Gam-negative bacteria. 👉 doi.org/10.1016/j.ym...
doi.org
Redirecting
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Pablo Ivan Nikel @pabnik.bsky.social · 09/07/2025
🚨 Due to popular demand, the deadline to apply for the @cshlnews.bsky.social course Advanced #SynBio & #Metabolic #Engineering of #Pseudomonas is extended to July 22! #PhD students & #postdocs welcome! 📍Suzhou, China 📅 Sept 7–21 🔗Apply now: csh-asia.org?content/2642
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Pablo Ivan Nikel @pabnik.bsky.social · 07/07/2025
Implementing synthetic serine cycles in #Pseudomonas putida unlock methanol assimilation in our favorite bug w/carbon conservation, led by ÒscarPuiggené @labnikel.bsky.social · #SynBio #MetabolicEngineering #Methanol published in @cp-trendsbiotech.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation
The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic…
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TOLERATE EU Project @tolerateeu.bsky.social · 30/06/2025
Today, the #TOLERATEProject held its 1st Review Meeting (M1–M18) with PO & PM highlighting our progress, innovation & first results. A key step to shape the road ahead! 🔬🌱💦 Learn more: tolerate-eu-project.com  #HorizonEurope #EUProjects #Biotechnology #SustainableAgriculture
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TOLERATE EU Project @tolerateeu.bsky.social · 01/07/2025
🌱⚖️ Is EU law keeping up with agri-food innovation? Our latest TOLERATE article explores how outdated GMO/NGT rules could hinder progress. Thanks to Mirta Alessandrini & Francesco Montanari for their legal insights. 👉 Read more: tolerate-eu-project.com/tolerate-agr...
tolerate-eu-project.com
TOLERATE - Agri-food Science & Law Join Forces Against Climate ChangeResurrecting Ancient Genes with Synthetic Biology to Tackle Modern Challenges - Cyprus Institute of Neurology & Genetics
Setting the scene Agriculture has been the most important source of sustenance for mankind for thousands of years. However, current farming practices are often singled out as key drivers of climate ch...
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labnikel.bsky.social @labnikel.bsky.social · 23/06/2025
Back from an inspiring week at #ME16 in our home #Copenhagen! 🌍 Engaging talks, exciting science, and amazing connections — we’re full of new ideas! 🎉 Big congrats to @giusifav.bsky.social for winning a poster award 🏆 🙌 And proud to have our PI @pabnik.bsky.social as co-chair of the event!
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Pablo Ivan Nikel @pabnik.bsky.social · 22/06/2025
Wrapping up a fantastic #ME16 #Copenhagen — a success by all measures! Honored to co-chair the meeting w/I. Borodina, M. Chang, A. Mirończuk, C. Vickers, V. Šťovíček, Y. Zhou, M. Köpke & M. Herrgård & to work w/an outstanding team of colleagues, engaging communities & topics all around the world
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Pablo Ivan Nikel @pabnik.bsky.social · 09/06/2025
Happy to host @kunjapur.bsky.social as a sabbatical #professor at DTU Biosustain, supported by Otto Mønsteds Fond! We share a passion for using #SynBio to engineer #microbes with non-natural building blocks for advanced #biotechology. He’s in #Europe — drop a line to connect & discuss cool #Science!
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Patricia Bernal @pbernalt6ss.eurosky.social · 12/05/2025
Great science @pabnik.bsky.social and collaborators!!
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Andrew D Hanson @adhansonlab.bsky.social · 16/04/2025
#SyntheticBiology postdoctoral position in our group in University of Florida's Horticultural Sciences department. Work is directed evolution to improve enzymes that underlie important crop traits ⬇️
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Sheila I. Jensen @sheilaijensen.bsky.social · 08/04/2025
1/2 New paper by our PhD student Sompot Antimanon, where he uses Pseudomonas putida as a biocatalyst for cinnamic acid production in a process that increase water use efficiency. Sompot reached a TRY of T=143 g/L, R= 2.25 g/L/h, and Y 1.50 g/g glc after 8 recycles. www.nature.com/articles/s41...
nature.com
High-efficiency water use and process performance for bioproduction of trans-cinnamic acid - Scientific Reports
Scientific Reports - High-efficiency water use and process performance for bioproduction of trans-cinnamic acid
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Cecilia G. Flocco @ceciliaflocco.bsky.social · 04/04/2025
The #SynMicro Group was est. just last year, with Markus Pötter & myself elected as its first speakers. We were fortunate to welcome @pabnik.bsky.social as our invited speaker, alongside outstanding short lectures from Anna C. Ngo, Tim Stoltmann, Laura da Silva Amorim and Daniel Stukenberg. 2/n
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Pablo Ivan Nikel @pabnik.bsky.social · 02/04/2025
Genetic dissection of cyclic di-GMP signalling in #Pseudomonas aeruginosa via systematic diguanylate cyclase disruption—led by Roman di Martino & Daniel Volke @labnikel.bsky.social @microbiotech.bsky.social #OpenAccess enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....
enviromicro-journals.onlinelibrary.wiley.com
Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption
All 32 diguanylate cyclase (DGC)-encoding genes of P. aeruginosa PA14 were interrupted by premature STOP codons, introduced through a multiplexed cytosine base-editor. The synthesis of c-di-GMP was i...
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Cecilia G. Flocco @ceciliaflocco.bsky.social · 24/03/2025
2/n If you are at #vaam2025, come join us for the Inaugural Symposium of the brand new #Synthetic #Microbiology Group, featuring @pabnik.bsky.social Center for Biosustainability DTU and a line up of rising stars ✨ #microsky @leibniz-dsmz.bsky.social programme.conventus.de/vaam-2025/pr...
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