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Lars Dietrich

@laahrs.bsky.social
1.9K followers 988 following 25 posts

I love bacteria. Biofilm metabolism & antibiotic tolerance dietrichlab.com Biological Sciences, Columbia University (a yawn is a silent scream for coffee)

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Reposted by Lars Dietrich
Ákos T Kovács @evolvedbiofilm.bsky.social · 30/09/2026
The phenotypic landscape of the model firmicute Bacillus subtilis PNAS from Carol A. Gross www.pnas.org/doi/10.1073/...
pnas.org
The phenotypic landscape of the model firmicute Bacillus subtilis | PNAS
Firmicutes are gram-positive bacteria with important roles in human health, disease, and industry. However, more than a quarter of genes in the mod...
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Tom Gauld @tomgauld.bsky.social · 24/09/2026
My latest @newscientist.com cartoon. many more here: www.newscientist.com/author/tom-gauld/
Image: A graph with lots of red dots clustered together in a curve. The are all looking upwards at a single red dot wearing sunglasses. 

Caption: Mike was an outlier and would probably be excluded from the study, but all the other data points secretly thought he was really cool.
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Vaughn Cooper @vscooper.micropopbio.org · 23/09/2026
Fantastic, comprehensive, useful review if you care about RNA modifications in bacteria: @asm.org @csdetweiler.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
Compendium of RNA modifications for bacterial stress adaptation | Microbiology and Molecular Biology Reviews
SUMMARYRNA modifications in the tRNA, rRNA, and mRNA constitute a widespread layer of post-transcriptional gene regulation, commonly known as the epitranscriptome. In bacteria, tRNA and rRNA modificat...
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Michael Baym @baym.lol · 13/09/2026
Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide
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Petra Levin @redrockcity.bsky.social · 19/09/2026
4 years (!) in the making, in this review Jade Wang and I detail the fundamental processes underlying growth, the cell autonomous nature of homeostatic control, and the contribution of stochasticity to both. TL;DR Bacteria are more like teenagers than you think. www.nature.com/articles/s41...
nature.com
Bacterial growth rate in populations and single cells - Nature Microbiology
In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a ce...
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Doudna Lab @doudna-lab.bsky.social · 19/09/2026
Out now in Science: Two papers from our lab reveal VIPR, an RNA-guided DNA-targeting system in bacteriophages, providing clues to the origins of CRISPR www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... Congrats to Peter Yoon, @kenjmloi.bsky.social @terryzzy.bsky.social, T.Docter & team
science.org
A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas
CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...
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Kathleen Bachynski @bachynski.bsky.social · 18/09/2026
“On Thursday, scientists reported that they had found another gene-editing defense in nature, this one in viruses… This system, called VIPR, appears to be more than four billion years old, and it seems be the evolutionary ancestor of CRISPR… It may prove to be the more powerful gene-editing tool”
nytimes.com
The Next Gene-Editing Technology May Also Be the Oldest
Scientists have discovered a powerful gene-targeting system in viruses. Billions of years old, VIPR seems to predate CRISPR and may be even more effective.
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Proceedings of the National Academy of Sciences @pnas.org · 18/09/2026
The “brain-eating amoebae” Naegleria fowleri normally hunts for bacterial prey in pond sediments. Its drive to squeeze into tiny crevices may help explain how it moves from the human nose through the sinus, along olfactory axons, and into the brain. In PNAS: ow.ly/3JCY50ZOPvg
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 25/08/2026
New in JB: Karin Sauer and colleagues update us on all the great science at the 10th American Society for Microbiology Conference on Biofilms. journals.asm.org/doi/10.1128/... @asm.org #JBacteriol @microsky.bsky.social
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Ákos T Kovács @evolvedbiofilm.bsky.social · 23/08/2026
Bacterial biosynthetic gene clusters Editorial by @evodivmet.bsky.social on the 16 articles published in the thematic issue in Essays in Biochemistry portlandpress.com/essaysbioche...
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Journal of Experimental Biology @jexpbiol.bsky.social · 20/08/2026
We love that @theguardian.com crowns an Invertebrate of the Year and 2026's winner is the leaf sheep, Costasiella kuroshimae, a green solar-powered slug tinyurl.com/556zwt9a Find out about another solar powered sea slug that takes cues from its chloroplasts doi.org/10.1242/jeb....
tinyurl.com
Winner of Invertebrate of the Year 2026 crowned – and it is the size of a grain of rice
The leaf sheep, a neon green solar-powered slug, has inspired at least one Pokémon character and triumphs in global ballot
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Typas Lab @typaslab.bsky.social · 20/08/2026
Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com. We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase. www.nature.com/articles/s41...
nature.com
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
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Vaughn Cooper @vscooper.micropopbio.org · 18/08/2026
Hey friends of microbial evolution and science education! I posted the talk about EvolvingSTEM for anyone unable to attend #ISME20 in New Zealand. youtu.be/xzHI05eH104
youtu.be
EvolvingSTEM at ISME2026: building science identity in students from grades 6-12
YouTube video by Vaughn Cooper
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 06/08/2026
Biofilm formation in #Bacillus subtilis is thought to precede sporulation, but T. Updegrove says that a subpopulation of sporulating cells triggers other cells to become biofilm formers via an intracellular metabolite (glycerol) repurposed as a signaling molecule (!) www.science.org/doi/10.1126/...
science.org
A metabolite morphogen coordinates multicellular development in Bacillus subtilis
Cell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 31/07/2026
Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 23/06/2026
Our Dept of Microbiology & Immunology @Geisel School of Medicine @Dartmouth has an opening for an Assistant Professor. Looking for programs bridging multiple areas in Micro & Immuno. A great place to be! Programs: www.M2P2.org www.dartmouthbiofilm.org Job ad: apply.interfolio.com/187637
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Boo Tseng Lab @btsenglab.bsky.social · 24/06/2026
The UNLV School of Life Sciences looking to hire someone to teach and assess online biology lecture and laboratories courses for non-biology majors. Come join my dept! Job ad: nshe.wd1.myworkdayjobs.com/en-US/UNLV-E...
nshe.wd1.myworkdayjobs.com
Assistant Professor-in-Residence in the College of Sciences [R0151583]
The University of Nevada, Las Vegas (UNLV) appreciates your interest in employment. We ask that you keep in mind the following when completing your application: Once you start the application process ...
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 24/06/2026
Submit to the JB Biofilms Collection! Research Articles & Minireviews on biofilm formation/dispersal, Abx tolerance, polymicrobial interactions, signalling, imaging & more. Submission deadline: 30 September 2026. journals.asm.org/journal/jb/b... @asm.org #JBacteriol #ASMjournals
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STCmicrobeblog @stcmicrobeblog.bsky.social · 27/06/2026
#FungiFriends
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Lars Dietrich @laahrs.bsky.social · 28/06/2026
Phenazine Pride #PrideMonth #bacterial_pigments Agar art by Marina Smiley
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Jan-Ulrik Dahl (Dahl lab, ISU) @janulrikdahl.bsky.social · 10/06/2026
Published in Infection and Immunity, Gracious Donkor and I explore the diverse mechanisms microbes employ to withstand ROS-mediated stress and discuss recent efforts to harness oxidative stress responses as a potential strategy for developing new antimicrobials. journals.asm.org/doi/10.1128/...
journals.asm.org
Implications of bacterial exposure to reactive oxygen and chlorine species | Infection and Immunity
Molecular oxygen (O2) is the preferred terminal electron acceptor of the electron transport chain due to its high redox potential and is therefore an essential driver of cellular metabolism in aerobic...
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Dr. Seema Mattoo @mattoolab.bsky.social · 05/06/2026
Day 1 of @asm.org #ASMmicrobe2026 was great! Wonderful reconnecting with the Microbiology community, including fellow @hypothesisfund.bsky.social family members @laahrs.bsky.social & @paulturnerlab.bsky.social!
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 31/05/2026
The TCA cycle and pentose phosphate pathway are linked to lipid droplet expansion in nitrogen-starved Lipomyces starkeyi cells www.biorxiv.org/content/10.64898/20…
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Daniel Pollak @danielpollak.bsky.social · 13/03/2026
Abstract suggesting that some protists can use symbiosis for magnetoreception. Promising direction, seeing as there have been zero magnetoreceptors discovered outside bacteria... www.nature.com/articles/s41...
media.tenor.com
a cartoon coyote is riding a skateboard with a magnet attached to it
Alt: Literal data about how magnetoreception works
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Kathleen Bachynski @bachynski.bsky.social · 12/05/2026
Why we must keep funding research: “The long scientific journey that led to the drug is a triumph of both public and private research funding, succeeding only after decades of false starts and dashed hopes — and the unraveling of conventional wisdom that turned out to be completely wrong.”
nytimes.com
How an ‘Impossible’ Idea Led to a Pancreatic Cancer Breakthrough
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Ele Willoughby @minouette.bsky.social · 02/05/2026
Time for a new edition of Canadian biochemist and medical researcher extraordinaire Maud Menten (1878-1960), 🐡🧪👩🏼‍🔬 #histsci coauthor of the Michalis-Menten equation, inventor of the azo-dye coupling which was the first example of enzyme histochemistry for imaging tissues and the first 🧵
Several copies of my Maud Menten portrait drying on a tabletop. Each linocut shows a portrait of biochemist and medical researcher Maud Menten (1879-1960) with the Michalis-Menten equation in blue and a histology image in pinks and purples in the background.
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Tiffany Zarrella @tiffzarrella.bsky.social · 11/04/2026
New insight published in @molecularmicro.bsky.social by @saraalexander.bsky.social + Mark Goulian about how the phosphotransfer system known as PTS-Ntr mediates methylglyoxal resistance via K+ transporters. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
An Escherichia coli Phosphotransferase System Modulates Methylglyoxal Resistance by Regulating Intracellular Potassium
Escherichia coli can survive methylglyoxal stress by modulating phosphorylation of a regulatory phosphotransferase system, which, in turn, regulates the activity of a potassium/proton antiporter. The...
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Alex Crits-Christoph @acritschristoph.bsky.social · 10/04/2026
An Asgard archaeon from a modern analog of ancient microbial mats (Current Biology) Beautiful microscopy of an Asgard archaeon, in the same family as Lokiarchaea, in syntrophy with a sulfate-reducing bacteria Very very nice paper we saw in preprint form: www.cell.com/current-biol...
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ASM @asm.org · 06/04/2026
#MicrobiologyMonday: Gliding motility allows cells to move smoothly along surfaces without flagella. Although this strategy has evolved independently across many microbial lineages, common mechanical principles emerge. Learn more in #JBacteriology: asm.social/2SJ
The diverse molecular mechanisms of cellular motility. (A) The rotary T9SS and conveyor belt of Flavobacterium johnsoniae. (B) The focal adhesin complex of Myxococcus xanthus. (C) The leg-like attachment machinery of Mycoplasma mobile. Additional mechanistic models of motility for Mycoplasma genitalium (21) and Mycoplasma pneumoniae (22–26) are described in the text, with additional details available in the cited literature. (D) Multiple Type IV pili strategically arranged at both sides of the septal wall ensure smooth, coordinated gliding in filamentous cyanobacteria. The molecular organization depicted is based on well-characterized Type IV pilus systems of cyanobacteria. (E) The actin and myosin-based glidosome of the apicomplexan Toxoplasma gondii. (F) The proposed raphe and actinomyosin system of the diatom Craspedostauros australis. (OM, outer membrane; IM, inner membrane; PG, peptidoglycan; IMC, inner membrane complex; pPM, parasite plasma membrane; hPM, host plasma membrane).
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Ákos T Kovács @evolvedbiofilm.bsky.social · 01/04/2026
Biofilm spatial structure and superinfection immunity modulate inter-phage competition @plosbiology.org by James Winans and Carey Nadell journals.plos.org/plosbiology/...
journals.plos.org
Biofilm spatial structure and superinfection immunity modulate inter-phage competition
Bacteriophages vary widely in life history strategy, but little is known about how these strategies influence host invasion and inter-phage competition in biofilms. This study explores the abilities o...
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Michael Baym @baym.lol · 17/03/2026
By all means, if you're deciding, take the time you need. But if you're deciding between two places, and there are three others you've ruled out, let those three know as soon as possible, not once you've picked a school You could make a huge difference to someone else's life
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Michael Baym @baym.lol · 17/03/2026
Annual reminder: if you’ve been accepted to multiple graduate programs and are still deciding, please let the ones you’re definitely not going to know as soon as possible! -Someone who got into his PhD off the waitlist the day after the deadline
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STCmicrobeblog @stcmicrobeblog.bsky.social · 11/03/2026
(bacterial) cell divisionists take note 👇 the schwille lab did it again! now adding FtsN*) to the party, with FtsA, FtsZ and the Min gang already on board... *) cytoplasm.domain thx séamus for pointing this out🙏 #MicroSky
smallthingsconsidered.blog
How FtsZ-rings get shov­eled to mid­cell in vitro
Pictures Considered #61 by Christoph — The last thirty years have been an "eye-open­ing" jour­ney for mi­cro­bial cell bio­logists, quite li­ter­al­ly. I am, of course, talk­ing about fluores­cent…
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Hypothesis Fund @hypothesisfund.bsky.social · 09/03/2026
Happy #InternationalWomensDay to the brilliant women in our Hypothesis Fund community who are taking the intellectual risks to pursue bold ideas, supporting one another, and transforming science together. You inspire us every day. 💫 #IWD2026
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Microbiology Society @microbiologysociety.org · 05/03/2026
#OnThisDay in 1938, American evolutionary biologist Lynn Margulis was born. Margulis is most known for developing and popularising the endosymbiotic theory, which explains how eukaryotic cells evolved organelles from simpler prokaryotic organisms that resided within another and became incorporated.
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Kathryn (Katy) Appler @katyappler.bsky.social · 18/02/2026
At long last! Check out the link to our publication in @nature.com to learn more. doi.org/10.1038/s415... 12/12
doi.org
Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature
Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgar...
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Carl Zimmer @carlzimmer.com · 18/02/2026
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22
A pilot in a submersible vehicle collecting sediments samples in 30 meters of water looking for Asgards (microbial relatives of eukaryotes)
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Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 09/02/2026
Preprint on the permeability of Gram+ bacterial cell wall from a few months ago. Intriguing findings, elegant methodology. Cell wall is largely impermeable to molecule sizes of mNeonGreen (27kDa) and above. How do larger secreted proteins get through? www.biorxiv.org/content/10.1... #microsky
biorxiv.org
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STCmicrobeblog @stcmicrobeblog.bsky.social · 06/02/2026
a daring approach: looking at LUCA's ancestors, i.e. pre-darwinian evolution. but not surprising it's coming from @kacarlab.bsky.social 👏 glad to see Iwabe et al. (1989) among the references (blew my mind when it came out >30 y ago)
Iwabe et al. (1989) Proc. Natl. Acad. Sci. USA
Vol. 86, pp. 9355-9359
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Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · 06/02/2026
Seema Mattoo on Bordetella pertussis and whooping cough! Matters Microbial, @mattoolab.bsky.social @markowenmartin.bsky.social #MicroSky
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Jamie Blaza @jnb-lab.bsky.social · 13/01/2026
@poojag96.bsky.social work on the bioenergetics of spore germination is now published- Pooja had a really nice summary that I've put below but essentially we think the role of bioenergetics in spore germination has been completely overlooked! www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Patrick R. Secor @prsecor.bsky.social · 28/01/2026
Friends, please help spread the word about our microbiology REU program at Montana State University. www.montana.edu/mbi/reu/ Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided. Details in the attached pic--Feb 14 deadline 🧫🧪🦠#microsky
This Research Experiences for Undergraduates (REU) program is funded by the National Science Foundation to create "points of entry" for students interested in research. Students apply from across the country to spend 10 weeks in Bozeman, Montana this summer (May 26, 2026 - August 1, 2026). Admitted students are paired with a faculty mentor, who serves as an advisor for a student's summer project. Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided.

Our program leverages MSU’s unique microbiology expertise, focusing specifically on microbes living with little or no oxygen (like those in the hot springs of nearby Yellowstone). Low oxygen microbes are essential to human and ecosystem health. They influence (or control) such processes as the breakdown of food in the GI tract, removal of toxins from our bodies and the environment, and production of greenhouse gases. They are also models for understanding the origins of life on this planet, and the potential for life on other planets.

A key goal of our program is to recruit students from schools with limited research infrastructure. Being in Montana, a state with a vibrant Native American community, we are particularly interested in applications from students at tribal colleges. However, ANYONE with an interest in microbiology - or biology/science in general - can and should apply.

If willing and able, please share/tweet/spread the word far and wide. Applications are due February 14, 2026. Full details can be found through our website http://www.montana.edu/mbi/reu/
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Cameron Thrash @jcamthrash.bsky.social · 20/01/2026
Metabolite toxicity as a driver of bacterial metabolite externalization www.biorxiv.org/content/10.6... #jcampubs
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 18/01/2026
Metabolic diversity of microorganisms toward atypical sugar enantiomers www.biorxiv.org/content/10.64898/20…
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ASM @asm.org · 12/01/2026
Valuable data sets are often overlooked because they are difficult to locate. The NIAID Data Ecosystem Discovery Portal provides a centralized, searchable interface that empowers users with varying technical expertise to find and reuse data. #mSystems: asm.social/2Lo
Overview of the NIAID data ecosystem interface and example search. (A) The landing page provides access to the Discovery Portal’s basic search interface. (B) Example search results for “Zika virus” data sets filtered by species: “Homo sapiens” and variableMeasured: “Proteomics,” demonstrating how users can refine results using structured metadata filters to support targeted data discovery.
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Ricard Solé @ricardsole.bsky.social · 11/01/2026
Why does life explore so few of the forms it could possibly take? Using fractal descriptors, this #scienceadvances paper shows that Earth’s biosphere clusters around simple shapes, reflecting deep evolutionary constraints. @artemyte.bsky.social @manlius.bsky.social www.science.org/doi/pdf/10.1...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 18/12/2025
Pete Greenberg's view in #JBacteriol: Pseudomonas aeruginosa, my model for research on quorum sensing, biofilms, and opportunistic infections journals.asm.org/doi/10.1128/...
journals.asm.org
Pseudomonas aeruginosa, my model for research on quorum sensing, biofilms, and opportunistic infections | Journal of Bacteriology
With encouragement from the Journal of Bacteriology Editor in Chief, George O’Toole, I have written this short essay in a style different than Journal of Bacteriology articles on model organisms. It i...
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Aeon Magazine @aeon.co · 18/12/2025
Some of the longest-lived organisms on Earth aren’t whales, trees or corals, but microbes buried deep in the earth. This eye-opening essay examines the slowest lives on Earth, asking what such lives mean for how we define life itself @karenlloyd.bsky.social
buff.ly
The discovery of aeonophiles expands our definition of life | Aeon Essays
The discovery of organisms that have been alive for many thousands of years requires a revolution in how we understand life
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c0nc0rdance @c0nc0rdance.bsky.social · 17/12/2025
“A process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known" - Bertrand Russell, 1976. Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. 🦠
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