Here the authors show that CM1 activates human γTuRC by facilitating its complete closure as the nascent microtubule assembles: high-resolution cryo-EM identifies interactions that promote and stabili...

La Dirección del Centro Nacional de Investigaciones Oncológicas (CNIO), el principal centro de investigación en cáncer de España y uno de los más productivos a escala global, ha presentado hoy al personal del centro su nuevo Plan de Actuación para 2026, aprobado por la unanimidad de su Patronato en diciembre pasado. El nuevo Plan, presentado por […]

Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

DescriptionWe are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biom...

Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...

An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...

The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range compl...

The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...

Palacios-Abella, López-Perrote et al. characterized the cochaperone R2T complex from Arabidopsis and determined its cryo-EM structure. R2T is organized as a double ring of hetero-hexameric AtRuvBL1/2a...

RISING TALENT FELLOWSHIP The MRC Laboratory of Molecular Biology (LMB) is proud to launch the next application round of its three-year fully funded

Methods in protein design have made it possible to create large and complex, self-assembling protein cages with diverse applications. These have largely been based on highly symmetric forms exemplifi...

Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...