Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at th...

Objectives Recent clinical studies have suggested that glucagon-like peptide-1 receptor (GLP-1R) agonists may be effective therapies to treat or reduce the risk of developing secondary lymphedema. I.....

The Pew Latin American Fellows Program in the Biomedical Sciences provides support for young scientists from Latin America to receive postdoctoral training in the United States. The program gives thes...

Target stiffness influences T cell polarization and gene expression through distinct Ca2+ channels.

Supriya Chakraborty might have been studying insects in a lab had it not been for an immunology college instructor in India who taught him about the superheroes inside him—immune cells that wage a battle against bacteria, parasites, and a host of other adversaries that invade our bodies.

PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

A possible new treatment for impaired brain blood flow and related dementias is on the horizon. Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides novel insights into the mechanisms that regulate brain blood flow and highlights a potential therapeutic strategy to correct vascular dysfunction.

Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...

The blood-brain barrier (BBB) regulates the extracellular composition of the central nervous system (CNS), but it is not known whether its properties differ across CNS regions. Here, the authors show ...

After finding the homeschooling life confining, the teen petitioned her way into a graduate class at Berkeley, where she ended up disproving a 40-year-old conjecture.