Mechanosensation isn't just at the cell surface. In gut smooth muscle, we found that Piezo1 is mostly intracellular, <40 nm from RyR and BK channels. Activating it hyperpolarizes cells and weakens contraction- like a molecular brake. Stay tuned for more to come! J Physiol: doi.org/10.1113/JP29...
doi.org
Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at th...
