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Journal of General Physiology @jgp.org · 2h

📣 Call for Papers ⏰ DEADLINE EXTENDED: November 30 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

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Journal of General Physiology @jgp.org · 29/09/2026

State-dependent inhibition of LRRC8 volume-regulated anion channels by DCPIB. New study from Toshiki Yamada, Erkan Karakas, and Jerod S. Denton @vanderbilt.edu: rupress.org/jgp/article/... #MolecularPharmacology #MembraneTransport #IonChannels

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Journal of General Physiology @jgp.org · 25/09/2026

A fluorescent non-hydrolyzable probe for the nucleotide binding sites of KATP. New study from Priscilla Rubio, Michael C. Puljung and coleagues @trinitycollege.bsky.social: rupress.org/jgp/article/... #Biochemistry #Biophysics #MolecularPhysiology #CellularPhysiology #IonChannels

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Journal of General Physiology @jgp.org · 24/09/2026

📣 2026 #CallForPapers on #Myofilaments is now open! The review process will be overseen by JGP Editor Henk Granzier, with Guest Editors and subject experts Brett Colson, Jonathan Kirk @jonathankirk.bsky.social, Julian Stelzer, and Jennifer Van Eyk. 👉 rupress.org/JGP/pages/ca...

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Journal of General Physiology @jgp.org · 23/09/2026

“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit.” — Chieko Koike, Ritsumeikan University Learn more about JGP: hubs.la/Q04t83Z10

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Journal of General Physiology @jgp.org · 22/09/2026

Yamada, Karakas, & Denton @vanderbilt.edu show that the prototypical LRRC8/VRAC inhibitor DCPIB stabilizes an inactivated channel state through coordinated interactions spanning extracellular, transmembrane, & N-terminal channel domains rupress.org/jgp/article/... #IonChannels #MolecularPharmacology

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Journal of General Physiology @jgp.org · 18/09/2026

KATP channels link a cell’s metabolic state to its electrical excitability through the binding of ADP/ATP to three classes of nucleotide-binding site. Rubio, Puljung et al. synthesize and characterize a fluorescent ATP derivative to probe the activity of these sites. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 17/09/2026

The proximal N terminus of IRAG is required for potentiation of HCN4 channels. New study from Lucas M. Blecker, John R. Bankston and colleagues @cuanschutz.bsky.social: rupress.org/jgp/article/... #MolecularPhysiology #MembraneTransport #Biophysics #IonChannels

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Journal of General Physiology @jgp.org · 17/09/2026

📣 Call for Papers ⏰ DEADLINE EXTENDED TO NOVEMBER 30, 2026 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26. Submit here 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers

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Journal of General Physiology @jgp.org · 17/09/2026

🔬 From our September issue (rupress.org/jgp/issue/15...): Compiled image of HEK cells showing both dark-field imaging and TMRM fluorescent signal. Colomer-Molera et al. show that structural determinants at KCNE4 position 145 govern Kv1.3 channel function. doi.org/10.1085/jgp....

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Journal of General Physiology @jgp.org · 10/09/2026

Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. Blecker, Bankston and colleagues describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. rupress.org/jgp/article/... #Biophysics #IonChannels #MolecularPhysiology

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Journal of General Physiology @jgp.org · 10/09/2026

#CallForPapers 📣 You are invited to submit papers on the topic “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease.” Learn more & submit here 👉 rupress.org/JGP/pages/ca...

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Journal of General Physiology @jgp.org · 09/09/2026

“JGP’s standards are trusted internationally, publication in the journal can lead to lasting visibility and recognition well beyond the immediate field.” — Chieko Koike, Ritsumeikan University Learn more about JGP: hubs.la/Q04t83Z10

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Journal of General Physiology @jgp.org · 07/09/2026

The many faces of #Orai1 dysfunction: Molecular mechanisms and clinical manifestations. New review from Magdalena Prantl, Lara Atzgerstorfer, Isabella Derler and colleagues @jku.at: rupress.org/jgp/article/... #IonChannels #Biophysics #ProteinDynamics #MembraneTransport #Pathophysiology

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Journal of General Physiology @jgp.org · 07/09/2026

On our September cover (rupress.org/jgp/issue/15...): Gaitán‑Peñas et al. (doi.org/10.1085/jgp....) show how the VRAC inhibitor DCPIB binds the extracellular selectivity filter through adaptable interactions, providing new insights into the molecular basis of channel inhibition.

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Journal of General Physiology @jgp.org · 03/09/2026

A hERG blocker facilitates K⁺ channel current by promoting pore opening while blocking. New study from Steffen Docken, Matthew Marquis, Kazuharu Furutani, Timothy Lewis, Jon Sack @ucd-physiology.bsky.social et al.: rupress.org/jgp/article/... #MolecularPharmacology #Biophysics #IonChannels

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Reposted by Journal of General Physiology

Tim @timisstuck.bsky.social · 03/09/2026

Here in lovely Woods Hole for the annual meeting @sgpweb.bsky.social, where I am delighted to chat about both @lsajournal.org and @jgp.org A great theme this year on excitability in human reproduction!! (My congrats to Sue on her impressive puddle)

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Journal of General Physiology @jgp.org · 03/09/2026

Tunable AMPA receptor function via recurrent #evolution of heterotetramers. New study from Yuhong Wang, Alexander Edwards, Jelena Baranovic, and Timothy Lynagh @msarscentre.bsky.social: rupress.org/jgp/article/... #MolecularPharmacology #MembraneTransport #Biochemistry #Biophysics #IonChannels

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Journal of General Physiology @jgp.org · 03/09/2026

Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated #ionchannel, ELIC. New study from Mark J. Arcario, Wayland W. L. Cheng and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/... #Biophysics #MembraneTransport

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Journal of General Physiology @jgp.org · 02/09/2026

📣 Call for Papers ⏰ DEADLINE APPROACHING: SEPTEMBER 30 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

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Journal of General Physiology @jgp.org · 01/09/2026

Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model. New study from Arooj Shahid, Mei Methawasin (University of Missouri) and colleagues: rupress.org/jgp/article/... #CardiacMuscle

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Reposted by Journal of General Physiology

UC Davis Physiology @ucd-physiology.bsky.social · 27/08/2026

#PMB researchers explore drug interactions with hERG channels in this paper from @jgp.org

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Journal of General Physiology @jgp.org · 31/08/2026

New review: Prantl, Atzgerstorfer, Derler et al. @jku.at catalog known disease-associated #Orai1 mutations, explain how they disrupt the activation sequence, and link them to their clinical impact. rupress.org/jgp/article/... #IonChannels #Biophysics #ProteinStructure #MembraneTransport

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Journal of General Physiology @jgp.org · 27/08/2026

Docken, Marquis, Furutani, Lewis, Sack @ucd-physiology.bsky.social et al. test the hypothesis that the antiarrhythmic drug nifekalant opens hERG gates while blocking, revealing a mechanism that may reduce #arrhythmia risk. rupress.org/jgp/article/... #IonChannels #MolecuarPharmacology #Biophysics

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Journal of General Physiology @jgp.org · 27/08/2026

Wang, Lynagh et al. investigated the biophysical function, pharmacology, and kinetics of AMPA receptors from diverse bilaterians, uncovering convergent #evolution on functional hallmarks, such as heteromerization & channel properties, throughout the AMPA receptor family. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 27/08/2026

Using #MolecularDynamics, computational #electrophysiology, and single-channel recordings, Arcario, Cheng et al. identify a cryptic extracellular lateral fenestration in the pentameric ligand-gated #ionchannel, ELIC, that becomes the dominant cation conduction pathway. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 26/08/2026

📣 #CallForPapers on #Myofilaments is now open! JGP welcomes submissions that focus on #myofilament structure, elasticity, and regulatory networks in muscle function and disease. Learn more and submit your work here 👉 rupress.org/JGP/pages/ca...

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Journal of General Physiology @jgp.org · 26/08/2026

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions. New approach developed by Ryan J. Farrell, Timothy A. Ryan @weillcornell.bsky.social and colleagues: rupress.org/jgp/article/... #Biophysics #MolecularPhysiology #CellularPhysiology

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Journal of General Physiology @jgp.org · 25/08/2026

Shahid, Methawasin et al. show that, in the #cardiomyocytes of male two-hit HFpEF-like model mice, both increased passive sarcomere stiffness and diastolic crossbridge activity represent potential therapeutic targets for reducing cardiomyocyte diastolic stiffness. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 25/08/2026

📣 Call for Papers ⏰ DEADLINE APPROACHING: SEPTEMBER 30, 2026 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26. Submit here 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers

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Journal of General Physiology @jgp.org · 24/08/2026

Crying time: modeling tear formation. New Commentary by Alan M. Weinstein @weillcornell.bsky.social on recent study by Varun Verma, Alan S. Verkman et al. (rupress.org/jgp/article/...): rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 19/08/2026

Farrell, Ryan @weillcornell.bsky.social and colleagues characterize a new ratiometric ER calcium indicator that uses HaloTag to normalize for reporter expression. The approach allows comparisons of ER Ca2+ concentration across cell types and subcellular regions. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 19/08/2026

The mitochondrial swelling channel. Elizabeth A. Jonas, Eleanora Margulis, Ava Yu, and Nelli Mnatsakanyan @mnatsakanyanlab.bsky.social discuss new JGP study from Akosah et al. of the Pavlov Lab (rupress.org/jgp/article/...). In Commentary: rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 18/08/2026

ATP1A1 variants spring a leak. Colmano, Self, Artigas et al. (doi.org/10.1085/jgp....) show that four variants associated w/ hypomagnesemia w/ treatment-resistant seizures all display passive leak currents that can likely explain both of these disease-specific symptoms. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 17/08/2026

Commentary: New study by Verma et al. (rupress.org/jgp/article/... applies a mathematical model of the cornea to guide treatment of #DryEye disease, favoring volume-directed over cell-directed therapies. Alan M. Weinstein highlights the findings: rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 17/08/2026

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired #lipid scramblase function. New study from Augustus J. Lowry, Huanghe Yang @huanghe-lab.bsky.social & colleagues @duke-university.bsky.social: rupress.org/jgp/article/... #IonChannels #Pathophysiology #MembraneTransport

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Journal of General Physiology @jgp.org · 13/08/2026

Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in #membranes. New study from Arpan Bysack and H. Raghuraman (Saha Institute of Nuclear Physics, Kolkata): rupress.org/jgp/article/... #ProteinStructure #MembraneTransport #Biophysics #IonChannels

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Journal of General Physiology @jgp.org · 13/08/2026

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies. From Kate Crowther, Thibault Jouen-Tachoire, Reza Maroofian @reza-maroofian.bsky.social, Stephen J. Tucker @profkalium.bsky.social @ox.ac.uk & colleagues: rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 13/08/2026

Differential Na⁺ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation. New study from Boris S. Zhorov (I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg): rupress.org/jgp/article/... #Biophysics #MembraneTransport

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Journal of General Physiology @jgp.org · 13/08/2026

📣 #CallForPapers on the topic “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease.” Submissions of all article types are welcome, incl. Research Articles, Communications, Hypotheses, Methods and Approaches, & Reviews 👉 rupress.org/JGP/pages/ca...

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Journal of General Physiology @jgp.org · 12/08/2026

Commentary: Akosah et al. (rupress.org/jgp/article/...) highlight the multifaceted nature of mitochondrial swelling, and its relationship to membrane potential changes, to mitochondrial permeability, and to activation of the mitochondrial permeability transition pore. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 12/08/2026

📣 Call for Papers 📣 You are invited to submit papers on the topic of the @sgpweb.bsky.social 2026 meeting, “Membrane Excitability and Reproductive Biology,” to be published throughout the year and highlighted in a special issue! Learn more and submit here 👉 rupress.org/JGP/pages/ca...

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Journal of General Physiology @jgp.org · 11/08/2026

Latest in our Research News: new study (Colmano et al. doi.org/10.1085/jgp....) identifies passive “leak” currents as a likely common mechanism underlying hypomagnesemia w/ treatment-resistant seizures in patients with certain mutations in the Na⁺, K⁺-ATPase α1 subunit. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 10/08/2026

Augustus J. Lowry et al. @huanghe-lab.bsky.social show that the disease-associated TMEM63B I475del variant uniquely promotes both mechanosensitive ion channel gain of function and acquired lipid scramblase activity. rupress.org/jgp/article/... #IonChannels #Pathophysiology

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Journal of General Physiology @jgp.org · 06/08/2026

“JUST-B was founded to create a more inclusive and equitable scientific community, and that work requires sustained support from partners who share that vision.”— Dr. Theanne Griffith (@doctheagrif.bsky.social). JGP, where scientists set the course 👉 hubs.la/Q04lcxPj0

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Journal of General Physiology @jgp.org · 06/08/2026

Locking the TMEM16A chloride channel into its conductive state. New Commentary from Zhang Feng (Nanjing Medical University) on a recent study from Stephens and colleagues (rupress.org/jgp/article/...) rupress.org/jgp/article/... #ChlorideChannels #IonChannels

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Journal of General Physiology @jgp.org · 06/08/2026

Zhorov shows that sodium channel antagonist bulleyaconitine and agonist aconitine bind in the pore-domain fenestration I/II & stabilize the open activation gate. Aconitine transiently chelates passing sodium ions, while protonated bulleyaconitine blocks the permeation. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · 06/08/2026

Bysack and Raghuraman show specific lipid–protein interactions mediate the cholesterol-induced reorganization of the slide helix in membranes during cholesterol-dependent regulation of KirBac1.1. rupress.org/jgp/article/... #MembraneTransport #Lipids #membranes #Biophysics #IonChannels

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Journal of General Physiology @jgp.org · 06/08/2026

Crowther, Jouen-Tachoire, @reza-maroofian.bsky.social, @profkalium.bsky.social et al. report new disease-causing variants in the TASK-1 and TASK-3 potassium channels responsible for two different neurodevelopmental disorders. rupress.org/jgp/article/... #Biophysics #IonChannels #Pathophysiology

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Journal of General Physiology @jgp.org · 06/08/2026

Giving structure meaning: Modelling the cellular synapse of excitation–contraction coupling in #SkeletalMuscle. Werner Melzer @uniulm.bsky.social highlights new study from Rios and Pizarro (rupress.org/jgp/article/...): rupress.org/jgp/article/...

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