Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Nature Reviews Genetics, Published online: 05 January 2026; doi:10.1038/s41576-025-00915-1Proteoforms are the diverse protein molecules produced from a single gene whose primary sequence and composition can be diversified by genetic, transcriptomic, translational and post-translational variation. This Review synthesizes technologies and network approaches to map, quantify and functionally characterize proteoforms, outlining routes to proteoform-guided biomarkers and therapeutics

YouTube video by David Fay

A focused analysis of the histone proteins and post-translational modifications in single cell proteomics provides insight into the heterogeneity of histone deacetylase inhibition.

Much effort has been spent clustering neurons into transcriptomic or functional cell types and characterizing the differences between them. Beyond sub…

Nature Reviews Genetics - Advances in long-read sequencing are driving the implementation of these technologies for transcriptome profiling. The authors provide a comprehensive guide to long-read...

These guidelines can help researchers ensure the integrity of their work while accelerating progress on important scientific questions.

Yuan et al. present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments.

The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...

Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

Chemical synapses are the principal communication nodes of the brain, defined by their specialization and plasticity. Their diversity spans multiple levels, from the polarity and magnitude of electrop...

GTP-binding protein 1 (GTPBP1) is a widespread translational GTPase closely related to elongation factor eEF1A. The loss of GTPBP1 leads to neurodevelopmental and neurodegenerative disorders in animals....

Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...

Eukaryotes coordinate their response to heat shock through an evolutionarily conserved mechanism involving mRNA operon expression.

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Apolipoprotein E4 (APOE4), the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), exacerbates tau tangles, amyloid plaques, neurodegeneration, and neuroinflammation—the pathologica...

Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.

RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...

CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.

Primary tauopathies are a group of neurodegenerative diseases characterised by the aggregation of tau in the brain. In these diseases, little is known about the molecular mechanisms driving neurodege....

A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create ov...

Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…

It has been proposed that the amygdala is required for the familiarity aspect of item recognition. By studying the performance of monkeys with selective amygdala lesions on four converging memory para...

Generative artificial intelligence (AI) systems can be optimized using TextGrad, a framework that performs optimization by backpropagating large-language-model-generated feedback; TextGrad enables optimization across diverse tasks, including radiotherapy treatment plans and molecule generation.

Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...

Neuronal AMPA receptors previously assumed to be calcium impermeable are unexpectedly shown to transport calcium ions.

Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.

An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.