The Life Sciences Departments in Harvard Faculty of Arts and Sciences seek to recruit a tenure-track professor whose research is at the interface of AI and life sciences, from methodological developme...

Deep-learning models have transformed our ability to predict the phenotypic effects of sequence perturbations. Protein language models (pLMs) score the evolutionary propensity of any amino-acid substi...

"To remain global leaders, a competitive economic power, and a sovereign actor, Europe needs strong science and innovation." Seven scientific organizations, representing...

Registration for the 2026 Virtual Cell Challenge is open at virtualcellchallenge.org. This year the task is zero-shot: we are not releasing a training set, and the evaluation dataset is far more expan...

🎉 New preprint: “Blending physics-based and inverse folding models to disentangle variant effects on stability and function” ➡️ Read it on https://lnkd.in/dCDw-3nb Together with Xavier Soler Sanchis...

Protein kinases are central to biological regulation, dysregulated in many diseases, and the targets of a hundred clinically-approved drugs. Structural conservation of kinase active sites makes the de...

Summary DeepMind has released AlphaGenome’s code and model weights, and the community has since developed alphagenome_ft and alphagenome-pytorch to enable seamless fine-tuning in both JAX and PyTorch....

Generating high-quality training data for machine learning is costly. Here, authors include sequence-to-function modeling in benchmarking of custom and commercial droplet-based scATAC platforms, and r...

Background Cell state-specific gene expression programs emerge from the interplay between cis-regulatory elements (CREs), such as enhancers, and transcription factors (TFs). Massively parallel reporte...

Nature Communications - How non-coding mutations in DNA contribute to phenotypes is a largely unresolved question. Here the authors integrate personal genomics and machine learning to identify...

Vota a las finalistas del premio Vanguardia de la Ciencia

Vota a las finalistas del premio Vanguardia de la Ciencia

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Dr. Núria López-Bigas, Group Leader, Biomedical Genomics Laboratory, IRB Barcelona.

Unified protein design for computational researchers and experimentalists

Cell Symposia: Decoding Cellular Complexity: Single Cell Biology in the Era of AI

Recent advances in large language models (LLMs) have opened new avenues for accelerating scientific research. While models are increasingly capable of assisting with routine tasks, their ability to co...

Knowledge distillation improves large language model (LLM) reasoning by compressing the knowledge of a teacher LLM to train smaller LLMs. On-policy distillation advances this approach by having the st...

Perplexity -- a function measuring a model's overall level of "surprise" when encountering a particular output -- has gained significant traction in recent years, both as a loss function and as a simp...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...

Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.