Google DeepMind's SynthID Bio is a proof of concept for embedding an imperceptible watermark in AI-generated protein sequences and predicted 3D structures. In wet-lab tests on three targets, watermark...

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

Adenine base editors (ABEs) enable efficient A:T to G:C conversion, but their broad activity windows frequently cause unintended bystander edits. We hypothesized that insertion of a bulky, inert prote...

Folddisco enables protein structural motif search in million scale databases.

Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis.

📣 📣 📣 Job alert!!! Join us at Karolinska Institutet We are looking for a postdoc to the Carlström lab curious to dissect metabolic and epigenetic interplay using iPSCs and animal models coupled with...

Thermogenetics enables spatiotemporal control of protein activity using temperature. Now, engineering of a compact, insertable thermoresponsive protein module diversifies the classes of proteins amena...

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.

Site-specific insertion of gene-sized DNA fragments remains an unmet need in the genome editing field. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombinati...

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...