Christopher Snow @cdsnow.bsky.social · 10/03/2026We built DNA scaffold crystals that can be reprogrammed to host different guest proteins for X-ray structure determination — no new crystallization screen required. This animation shows a guest protein (glowing) seeking its designed binding site inside the crystal lattice. shorturl.at/DANdc 2235
Reposted by Christopher Snow@tim_stasevich @tim-stasevich.bsky.social · 12/02/2025Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1... 1222196
Christopher Snow @cdsnow.bsky.social · 11/02/2025Very pleased with this ProteinMPNN-based collaboration that ballooned to encompass an impressive number of redesigned proteins for intracellular biomolecular recognition! www.biorxiv.org/content/10.1...biorxiv.org 052
Christopher Snow @cdsnow.bsky.social · 25/11/2024AlphaFold3 Cautionary Tale: We deposited multiple PDB entries for “CJ,” a binding protein that domain swaps when crystallizing. Local AF3 in the presence of decane gives the domain swapped form with high confidence extended N-terminus (4/5 models). Yikes! Perhaps template-driven false confidence... 050
Reposted by Christopher SnowBrian Munsky @brian-munsky.bsky.social · 22/11/2024The W Scott College of Engineering has announced a cluster of 10 new openings for tenure track professors in Engineering with Artificial Intelligence. We'd love for you to join our beautiful and supportive community! Please repost. jobs.colostate.edu/postings/152...jobs.colostate.eduEngineering with Artificial Intelligence Assistant/Associate Professor - All FieldsThe Walter Scott, Jr. College of Engineering at Colorado State University announces a College-wide search for six new faculty members who use artificial intelligence (AI) as a key component of their r... 011
Christopher Snow @cdsnow.bsky.social · 17/11/2024Hi folks, to those teaching courses where it is useful to know the one letter amino acid code, I used Suno to make a mnemonic song (Bossa nova style...) suno.com/song/8ce2f2e...suno.comAmino Acids by @entertainingchurchchoir073 | Suno1960s bossa nova song. Listen and make your own with Suno. 052