Abstract. Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented o

Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate within Cancer Pharmacology at the Rutgers Cancer Institute.The primary purpose of the Postdoctoral Associate position is...

Nutrients are important environmental factors that affect the functional responses of MAIT cells to challenge.

T cell activation requires major metabolic adaptation. Here authors find that in mice and humans, expression of the NAD/H-synthesis enzyme nicotinamide riboside kinase 1 (NRK1) increases in CD4+ T cel...

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A significant proportion of patients with myasthenia gravis (MG) remain refractory to standard immunosuppressive therapy, and biomarkers to help guide…

Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cell...

Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

Dietary interventions show therapeutic potential in cancer, but systematic comparisons are lacking. We performed a dietary pan-amino acid dropout screen in an orthotopic model of NOTCH1-driven T-cell ...

Single-cell RNA sequencing allows defining cellular identities based on transcriptional similarity using unsupervised clustering. However, a single clustering resolution may not yield groups of cells ...

Choi et al. show that pharmacologically restricting glycolysis improves the cellular, transcriptional, and metabolic machinery in murine lupus TFH cells. Transcript overlaps between TFH cells from lup...

Th17 cells play roles in maintaining immune homeostasis but also potentially harmful inflammatory processes. Here, authors show that homeostatic and pathological Th17 cells are distinct subtypes, resp...

Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate within the Cancer Pharmacology Department at the Rutgers Cancer Institute. In this role, the Postdoctoral Associate will...

Given that reduced expression of ABHD11 within CD4+ T-cells is associated with remission in RA21, we sought to better understand the role of ABHD11 in T-cell biology. Firstly, we established the degree of ABHD11 protein expression in human CD4+ T-cells,...

A new study led by Swansea University has revealed a new way to potentially treat certain autoimmune diseases by targeting a protein that helps regulate energy production in immune cells.

α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…

Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

Leukemia - Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia

Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory phenotype, with each underpinning the other. Over the past decade, new classes of drug, such as glucagon-like...

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