Childhood-onset systemic lupus erythematosus (cSLE) is a severe autoimmune disease with significant morbidity and enhanced type I interferon (IFN-I) signalling, potentially contributing to its aggress...

Based within the UCL Division of Medicine, The Department of Ageing, Rheumatology & Regenerative Medicine combines different disciplines to improve health and find new cures for disease. Our departmen...

Childhood-onset SLE is characterized by high disease activity, severe organ damage and substantial treatment challenges. The authors of this Review provide an update on the advances in the understandi...

Yurdagul and colleagues offer an integrated picture of metabolic changes at the cellular and at the lesion level in atherosclerosis.

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Children with a rare, debilitating muscle disease could benefit from the findings of new research by experts at UCL and Great Ormond Street Hospital (GOSH).

Nature Reviews Rheumatology, Published online: 01 September 2025; doi:10.1038/s41584-025-01291-0In this Review article, the potential of cytometry- and single-cell RNA sequencing-based immune profiling for aiding the diagnosis and personalized treatment of rheumatic diseases is discussed.